6952-53-0

Basic information

• Product Name: 2-METHYLPROYL 2-PYRIDYL KETONE
• Synonyms: 2-METHYLPROYL 2-PYRIDYL KETONE;2-(Isobutylcarbonyl)pyridine;2-Methylpropyl 2-pyridyl ketone
• CAS NO: 6952-53-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 6952-53-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 241.9°C at 760 mmHg
• Flash Point: 106.2°C
• Appearance: /
• Density: 0.994g/cm³
• Vapor Pressure: 0.0349mmHg at 25°C
• Refractive Index: 1.499
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: 2-METHYLPROYL 2-PYRIDYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLPROYL 2-PYRIDYL KETONE(6952-53-0)
• EPA Substance Registry System: 2-METHYLPROYL 2-PYRIDYL KETONE(6952-53-0)

Safety Data

• Hazardous Substances Data: 6952-53-0(Hazardous Substances Data)

Usage

General Description

2-Methylpropyl 2-pyridyl ketone is a chemical compound with the molecular formula C11H15NO. It is a ketone derivative with a pyridine ring attached to a chain of 2-methylpropyl groups. This chemical is commonly used as a building block in organic synthesis and has applications in the pharmaceutical and agrochemical industries. It is known to act as a chiral auxiliary in asymmetric synthesis and can also be utilized as a ligand in transition metal catalysis. Additionally, 2-methylpropyl 2-pyridyl ketone has been studied for its potential medicinal properties, including its anticancer and anti-inflammatory effects.

InChI:InChI=1/C10H13NO/c1-8(2)7-10(12)9-5-3-4-6-11-9/h3-6,8H,7H2,1-2H3

Upstream product

• 100-70-9 2-Cyanopyridine 
• 926-62-5 isobutylmagnesium bromide 
• 503-74-2 3-methylbutyric acid 
• 109-04-6 2-bromo-pyridine 
• 147356-77-2 N-methoxy-N,3-dimethylbutanamide 

Downstream Products

• 1122-62-9 2-acetylpyridine 
• 138835-93-5 2,2-Dimethyl-1-pyridin-2-yl-cyclopropanol 
• 138835-94-6 3-Methyl-1-pyridin-2-yl-cyclobutanol 
• 138835-95-7 3-Methyl-1-pyridin-2-yl-cyclobutanol 
• 1452507-31-1 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one 
• 68141-26-4 6-(2-methylpropyl)quinoline 
• 7661-51-0 4-isobutylquinoline 
• 1263198-29-3 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-3-methyl-1-(2-pyridyl)butyl]carbamoyl}piperidine-1-carboxylate 
• 1263197-17-6 C₂₈H₃₈ClN₅O₂ 
• 825647-69-6 3-methyl-1-(pyridin-2-yl)butan-1-amine 
• 127142-27-2 2-(3-methylbutyryl)pyridine 5-<(2-chloroanilino)thiocarbonyl>thiocarbonohydrazone 

Relevant articles and documents

Synthesis of new cyclazines and 4,5-diaryl-1 H -pyrrol-3(2 H)-one units in discoipyrroles from indolizinone-DMAD cycloadducts

The reaction of indolizinones with dimethyl acetylenedicarboxylate gave direct access to 3′,8a-dihydrocyclopenta[hi]indolizin-8a-ol and 1H-pyrrol-3(2H)-one in good yields. The former skeleton is a precursor to cyclazines with nitrogen on the periphery, a hitherto un-accessed 10-π system. Their formation involves initial [4 + 2] or [8 + 2] modes of cycloadditions; the retro-Diels Alder reaction of the [4 + 2] cycloadduct leads to 1H-pyrrol-3(2H)-one, whereas [8 + 2] addition followed by π-reorganization leads to the azatricyle. Analysis of substituent effects on product distribution showed that electron donating groups on the C3-aryl ring promote the formation of the azatricycle preponderantly. Treatment of one of these azatricycles (3c) with HBF4 led to the formation of the corresponding 10e-aromatic species which was detected by NMR spectroscopy. In addition, formation of the 1H-pyrrol-3(2H)-one skeleton through the normal retro-Diels Alder pathway was employed in the total synthesis of Discoipyrrole C, which is a new lead against lung cancer.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

Triplet states mediating hydrogen abstraction in 4-acylpyrimidines, 2-acylpyridines, 2-acylpyrazines, and 3-acylpyridazines

Irradiation of 9 leads to hydrogen abstraction by N(1) and fragmentation to 8 from a triplet with ET ～78 kcal/mol. Irradiation of 2-acylpyridines (10) leads to abstraction by both nitrogen and oxygen (cf. eq 4), with the same Stern-Volmer kqτ for the two processes. Irradiation of 2-acylpyrazines (11) can lead to abstraction by either nitrogen (φ27 0.77 from 11b) or oxygen (φ11a 0.95 from 11f)- 3-Acylpyridazine 12d is unreactive on direct irradiation or triplet sensitization with sensitizer ET ～70 kcal/mol; it furnishes a small amount of 12a on sensitization by acetone. Ketone 18 is recovered unchanged from irradiation under all conditions used with 12d. These observations suggest a correlation between the photochemistry of each of these compounds and the energy of the nπ* triplet of the heteroaromatic ring. The nature of the excited state(s) responsible for hydrogen abstraction by nitrogen and oxygen in these ketones is discussed.