1452507-31-1

Basic information

• Product Name: 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one
• Synonyms: 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one
• CAS NO: 1452507-31-1
• Molecular Weight: 339.391
• Mol File: 1452507-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one(1452507-31-1)
• EPA Substance Registry System: 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one(1452507-31-1)

Safety Data

• Hazardous Substances Data: 1452507-31-1(Hazardous Substances Data)

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 932-82-1 4,5-dibromo-1H-pyrrole-2-carbaldehyde 
• 53164-84-4 4,5-bis(4-methoxyphenyl)-1H-pyrrole-2-carbaldehyde 
• 30011-17-7 5-isobutyl-2,3-bis(4-methoxyphenyl)-1H-pyrrole 
• 6952-53-0 3-methyl-1-(pyridin-2-yl) butan-1-one 
• 503-74-2 3-methylbutyric acid 

Relevant articles and documents

Synthesis of new cyclazines and 4,5-diaryl-1 H -pyrrol-3(2 H)-one units in discoipyrroles from indolizinone-DMAD cycloadducts

The reaction of indolizinones with dimethyl acetylenedicarboxylate gave direct access to 3′,8a-dihydrocyclopenta[hi]indolizin-8a-ol and 1H-pyrrol-3(2H)-one in good yields. The former skeleton is a precursor to cyclazines with nitrogen on the periphery, a hitherto un-accessed 10-π system. Their formation involves initial [4 + 2] or [8 + 2] modes of cycloadditions; the retro-Diels Alder reaction of the [4 + 2] cycloadduct leads to 1H-pyrrol-3(2H)-one, whereas [8 + 2] addition followed by π-reorganization leads to the azatricyle. Analysis of substituent effects on product distribution showed that electron donating groups on the C3-aryl ring promote the formation of the azatricycle preponderantly. Treatment of one of these azatricycles (3c) with HBF4 led to the formation of the corresponding 10e-aromatic species which was detected by NMR spectroscopy. In addition, formation of the 1H-pyrrol-3(2H)-one skeleton through the normal retro-Diels Alder pathway was employed in the total synthesis of Discoipyrrole C, which is a new lead against lung cancer.