67498-53-7

Basic information

• Product Name: 7a-methyl-3-methylidenehexahydro-1-benzofuran-2(3H)-one
• Synonyms: 7a-Methyl-3-methylenehexahydro-1-benzofuran-2(3H)-one; 7a-Methyl-3-methylenehexahydrobenzofuran-2-one
• CAS NO: 67498-53-7
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.217
• Mol File: 67498-53-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 284.5°C at 760 mmHg
• Flash Point: 114.6°C
• Density: 1.06g/cm³
• Vapor Pressure: 0.00296mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: 7a-methyl-3-methylidenehexahydro-1-benzofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7a-methyl-3-methylidenehexahydro-1-benzofuran-2(3H)-one(67498-53-7)
• EPA Substance Registry System: 7a-methyl-3-methylidenehexahydro-1-benzofuran-2(3H)-one(67498-53-7)

Safety Data

• Hazardous Substances Data: 67498-53-7(Hazardous Substances Data)

Upstream product

• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 591-49-1 1-methylcyclohex-1-ene 
• 128071-58-9 (E)-3-Chloro-2-(2-chloro-2-methyl-cyclohexyl)-acrylic acid 
• 128071-53-4 2-Chloro-3-(2-chloro-2-methyl-cyclohexyl)-cycloprop-2-enone 
• 113426-65-6 1-Chloro-1-methyl-2-(2,3,3-trichloro-cycloprop-1-enyl)-cyclohexane 
• 128071-71-6 (2-Chloro-2-methyl-cyclohexyl)-propynoyl chloride 
• 150546-39-7 3-Methyl-3-(1,2-propadienyloxy)-1-cyclohexene 
• 13373-66-5 1-Methyl-2-oxabicyclo<3.3.0^1,5>nonan-3-one 
• 118893-25-7 diethyl 2-(2-methyl-2-cyclohexen-1-yl)propane-1,3-dioate 
• 321166-01-2 (2-methyl-cyclohex-2-enyl)-acetic acid 
• 71593-68-5 ethyl (2-methyl-2-cyclohexenyl)acetate 
• 13295-90-4 2-methyl-2-cyclohexen-1-yl acetate 
• 20461-30-7 2-methylcyclohex-2-en-1-ol 

Relevant articles and documents

Lactones, part 28: A new approach for the synthesis of α-methylene lactones from alkenes

A facile two-step procedure for synthesis of α-methylene lactones from alkenes and cycloalkenes is presented. Reactions carried out on some monoterpene alkenes afforded corresponding lactones in enantiomerically pure forms. Georg Thieme Verlag Stuttgart.

Synthetic studies towards (+)-Dihydroampullicin. Michael addition of N-Boc-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole to α-methylene lactones

The Michael addition of N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole (4) to several α-methylene lactones catalyzed by fluoride ions yielded the corresponding homologated products (26-30) with good yields. Application of this react

Synthesis of bicyclic α-methylene butyrolactones via alkoxycarbonylation of molybdenum-propargyl compounds

Syntheses of various bicyclic α-methylene butyroladones from functionalized propargyl bromides were carried out in short steps, the overall yields are reasonable. The key step involves alkoxycarbonylation of molybdenum-propargyl compounds.