6298-19-7 Usage
Description
2-Chloro-3-pyridinamine is an organic compound with the chemical formula C5H5ClN2. It is an off-white to yellow to pink crystalline powder and is known for its role as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. This versatile compound is also involved in Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds, which are significant in the formation of complex molecular structures.
Uses
Used in Pharmaceutical Industry:
2-Chloro-3-pyridinamine is used as a chemical intermediate for the synthesis of various medications. Its presence in the development process is crucial due to its ability to form complex molecular structures, which can be tailored for specific therapeutic applications.
Used in Agricultural Chemicals Industry:
In the agricultural chemicals industry, 2-Chloro-3-pyridinamine is utilized as an intermediate in the production of pesticides and other agrochemicals. Its involvement in the synthesis process contributes to the development of effective compounds that can protect crops from pests and diseases.
Used in Chemical Synthesis:
2-Chloro-3-pyridinamine is used as a key component in Suzuki-Miyaura cross-coupling reactions, which are essential for the formation of heteroaryl compounds. These reactions play a significant role in the creation of complex molecular structures with potential applications in various fields, including materials science, pharmaceuticals, and agrochemicals.
Overall, 2-Chloro-3-pyridinamine is a versatile compound with applications in multiple industries, primarily due to its role as a chemical intermediate and its involvement in crucial chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 6298-19-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6298-19:
(6*6)+(5*2)+(4*9)+(3*8)+(2*1)+(1*9)=117
117 % 10 = 7
So 6298-19-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2
6298-19-7Relevant articles and documents
METHOD OF REDUCING AROMATIC NITRO COMPOUNDS
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Paragraph 0332; 0345, (2022/02/26)
A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.
Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes
Fu, Lihua,Li, Dingzhong,Lu, Hao,Qiu, Renhua,Sun, Tulai,Xing, Chen,Yang, Tianbao
, (2022/01/11)
The development of green and efficient methods for hydrogenation of nitroarenes is still highly demanding in organic synthesis. Herein, we report an industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate 4m can be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol features cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).
Method for preparing 2, 3 -dichloropyridine from chlorination
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Paragraph 0011; 0049-0054; 0057-0058, (2021/11/03)
The invention relates to a method for preparing 2 and 3 - dichloropyridine from chlorination. The method introduces the graphene oxide catalyst in the traditional 3 - aminopyridine chlorination step, reduces the concentration and the dosage of hydrochloric acid and hydrogen peroxide, improves the selectivity of 2 -position chlorination, and reduces the generation of 2, 6 - dichloro -3 - aminopyridine. , The process enables high yield to obtain 2 - chloro -3 - aminopyridines of higher quality. , The method has good environmental friendliness and economical efficiency, and is suitable for being popularized and used in industry.