622-86-6 Usage
Description
2-Phenoxyethyl chloride, also known as (2-Chloroethoxy)benzene or Phenyl 2-Chloroethyl Ether, is an organic compound with the chemical formula C8H9ClO. It is a pale yellow oil at room temperature and is commonly used in various organic synthesis processes due to its reactive nature.
Uses
Used in Organic Synthesis:
2-Phenoxyethyl chloride is used as a synthetic intermediate for the production of various organic compounds. Its reactivity allows it to be a valuable building block in the synthesis of different molecules, contributing to the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Phenoxyethyl chloride is used as a key component in the synthesis of pseudo-symmetrical tamoxifen derivatives. Tamoxifen is a selective estrogen receptor modulator (SERM) that is widely used in the treatment of breast cancer. 2-Phenoxyethyl chloride plays a crucial role in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane, and anisole, which are essential steps in the production of these tamoxifen derivatives.
Used in Chemical Research:
2-Phenoxyethyl chloride is also utilized in chemical research as a versatile reagent for the preparation of various functional groups and molecular structures. Its unique properties make it an attractive candidate for exploring new reaction pathways and developing innovative synthetic methods in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 622-86-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 622-86:
(5*6)+(4*2)+(3*2)+(2*8)+(1*6)=66
66 % 10 = 6
So 622-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClO/c9-6-7-10-8-4-2-1-3-5-8/h1-5H,6-7H2
622-86-6Relevant articles and documents
Okamoto et al.
, p. 1905,1908 (1967)
NMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides
Zheng, Dagui,Mao, Liu-Liang,Zhu, Xian-Hong,Zhou, An-Xi
supporting information, p. 2793 - 2800 (2018/11/06)
NMP-mediated chlorination of aliphatic alcohols has been developed for the synthesis of alkyl chlorides. This facile, efficient and practical approach used simple and readily available aryl sulfonyl chlorides as the chlorination reagent for the construction of C–Cl bond in good to excellent yields with mild conditions and broad substrate scope.
Formononetin derivatives and preparation methods and medical application thereof
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, (2017/04/29)
The invention relates to the field of pharmaceutical chemistry, and relates to formononetin derivatives and preparation methods and medical application thereof, in particular to formononetin derivatives with the general formula as shown in (I), preparation methods thereof, pharmaceutical compositions containing the compounds and medical application of the derivatives and the pharmaceutical compositions, particularly, application of the derivatives and the pharmaceutical compositions serving as drugs for preventing or treating hyperlipidaemia or obesity or type-II diabetes. Please see the formula in the description.
TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE
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Paragraph 0232; 0233, (2016/12/22)
Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.