62050-98-0

Basic information

• Product Name: N-benzyl-4-hydroxy-4-phenylbutanamide
• CAS NO: 62050-98-0
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.3383
• Mol File: 62050-98-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 517.1°C at 760 mmHg
• Flash Point: 266.5°C
• Density: 1.138g/cm³
• Vapor Pressure: 1.61E-11mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: N-benzyl-4-hydroxy-4-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-4-hydroxy-4-phenylbutanamide(62050-98-0)
• EPA Substance Registry System: N-benzyl-4-hydroxy-4-phenylbutanamide(62050-98-0)

Safety Data

• Hazardous Substances Data: 62050-98-0(Hazardous Substances Data)

Upstream product

• 7510-08-9 N-benzyl-4-oxo-4-phenylbutanamide 
• 2051-95-8 succinylbenzene 
• 100-46-9 benzylamine 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 87605-11-6 propynoic acid benzylamide 
• 100-52-7 benzaldehyde 
• 170805-75-1 N-benzyl-4-hydroxy-4-phenyl-2-butynamide 

Downstream Products

• 215391-92-7 4-(benzylamino)-1-phenylbutan-1-ol 
• 7510-08-9 N-benzyl-4-oxo-4-phenylbutanamide 

Relevant articles and documents

THIOETHER TRIAZOLOPYRIDINE AND TRIAZOLOPYRMIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I):wherein A, X and Y are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Acid promoted cyclodehydration of amino alcohols with amide acetal

A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.

Acetylenic Amides. 2. The Generation and Reactions of Dianions Derived From 2-Propynamides

The dianion of N-benzyl-2-propynamide can be generated by the treatment of 4 with two equivalents of LDA at -65 deg C or ethylmagnesium bromide at -20 deg C.The trilithio species 6 is readily formed using 3 equivalents of LDA.Reaction of 5 with aldehydes or ketones produce hydroxypropynamides 9 in good yields.Silation of 5a with chlorotrimethylsilane produces N-benzyl-3-trimethylsilyl-2-propynamide (13) in high yield.Reduction of 9 furnishes either fully saturated amides 15 or partially reduced cis-olefins 16 or 18.Compounds 16, on heating, rearrange to 4-ketoamides 17.Carboxylation of 5a with carbon dioxide produces 3-benzyl-2,4-dioxo-5-oxazidinylacetic acid (11).Warming 11 in dimethyl sulfoxide results in the loss of carbon dioxide and the formation of N-benzylpyruvamide (21).