6155-57-3

Basic information

• Product Name: Saccharin sodium dihydrate
• Synonyms: 2-SULFOBENZOIC AND IMIDE SODIUM SALT DIHYDRATE;2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE;1,1-DIOXIDE-1,2-BENZISOTHIAZOLE-3(2H)-ONE SODIUM SALT, DIHYDRATE;O-BENZOIC ACID SULFIMIDE SODIUM SALT DIHYDRATE;O-BENZOIC SULFIMIDE SODIUM SALT;O-BENZOIC SULFIMIDE SODIUM SALT DIHYDRATE;O-SULFOBENZIMIDE SODIUM SALT DIHYDRATE;SOLUBLE SACCHARIN
• CAS NO: 6155-57-3
• Molecular Formula: C₇H₄NO₃S*2H₂O*Na
• Molecular Weight: 242.2
• EINECS: 204-886-1
• Product Categories: FOOD ADDITIVES;pharmacetical;Food & Flavor Additives;Fine chemicals
• Mol File: 6155-57-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: > 300℃
• Boiling Point: 438.9 °C at 760 mmHg
• Flash Point: 219.3 °C
• Appearance: White crystal powder
• Vapor Pressure: 1.77E-08mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: 1000g/l
• Water Solubility: Soluble in water. Slightly soluble in alcohol
• Merck: 14,8311
• CAS DataBase Reference: Saccharin sodium dihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Saccharin sodium dihydrate(6155-57-3)
• EPA Substance Registry System: Saccharin sodium dihydrate(6155-57-3)

Safety Data

• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 2
• RTECS: DE4375000
• TSCA: Yes
• Hazardous Substances Data: 6155-57-3(Hazardous Substances Data)

Usage

Chemical Properties

dihydrate granular

Uses

Different sources of media describe the Uses of 6155-57-3 differently. You can refer to the following data:
1. Sweetener (non-nutritive).
2. Saccharin Sodium Salt Dihydrate is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.

References

https://en.wikipedia.org/wiki/Saccharin https://pubchem.ncbi.nlm.nih.gov/compound/saccharin#section=Top

InChI:InChI=1/C7H5NO3S.Na.2H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;;/h1-4H,(H,8,9);;2*1H2/q;+1;;/p-1

Synthetic route

chloro(2,2':6',2''-terpyridine)platinum(II) chloride dihydrate + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) → [(2,2':6',2''-terpyridine)chloroplatinum(II)]saccharinatedihydrate

Conditions	Yield
In water silid metal complex dissolved in H2O at 60°C, treated with 1 equiv. of Na saccharinate dihydrate (2 equiv.), stirred at 60°C for 30 min; treated with EtOH, crystd. at room temp. for 3 d, elem. anal.;	95%

[(2,2':6',2''-terpyridine)chloropalladium(II)]chloride dihydrate + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) → [(2,2':6',2''-terpyridine)chloropalladium(II)]saccharinate dihydrate

Conditions	Yield
In water silid metal complex dissolved in H2O at 60°C, treated with 1 equiv. of Na saccharinate dihydrate (2 equiv.), stirred at 60°C for 30 min; treated with EtOH, crystd. at room temp. for 3 d, elem. anal.;	95%

[(2,2':6',2''-terpyridine)chloropalladium(II)]chloride dihydrate + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [(2,2':6',2''-terpyridine)(saccharinate)palladium(II)]saccharinate - water (1/2.5)

Conditions	Yield
In water byproducts: AgCl; silid metal complex and solid AgNO3 (1:2) added to H2O, refluxed for 6 h, AgCl filtered (celite), concd., treated with Na saccharinate dihydrate(2 equiv.), stirred at 60°C for 30 min; mixed with EtOH, crystd. at room temp. for 2 d, elem. anal.;	94.4%

2-Methylpyrazine (109-08-0) + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → Ag4(saccharinate)4(2-methylpyrazine)2(H2O)2

Conditions	Yield
In water; acetonitrile solid Na(sac)*2H2O mixed with 1 equiv. of AgNO3 in H2O, pptd., dissolvedin CH3CN, treated with 1 equiv. of 2-methylpyrazine, stirred at room te mp. for 30 min; crystd. at room temp. in the dakness for 2 d, elem. anal.;	94%

1-(2-aminoethyl)pyrrolidine (7154-73-6) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [Ag2(saccharate)2(N-(2-aminoethyl)pyrrolidine)2]

Conditions	Yield
In water; isopropyl alcohol a soln. of Na-saccharate in water was mixed with AgNO3 in water-2-propanol (1:3) with stirring, pyrrolidine-compound was added, the mixt. was stirred for 30 min at room temp.; allowed to stand in darkness at room temp. for 4 days; elem. anal.;	93%

1H-imidazole (288-32-4) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [Ag(saccharinate)(imidazole)]*2H2O

Conditions	Yield
In water; isopropyl alcohol; acetonitrile aq. soln. of Na salt mixed with soln. of AgNO3 in H2O-i-PrOH (1:3) with stirring, ppt. dissolved in MeCN and N compd. added; evapd. slowly in dark at room temp. for 2 d; elem.anal;	93%

S,S'-diphenylsulfimide monohydrate + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → Ag(saccharinato)(S,S-diphenylsulfimide) (930301-72-7)

Conditions	Yield
In dichloromethane; water Na-salt mixed with soln. of AgNO3 in H2O, ppt. dissolved in CH2Cl2, ligand added, stirred for 30 min at room temp., allowed to stand in darknessat room temp. for 2 wk; elem. anal.;	89%

sodium saccharinate dihydrate (6155-57-3) + zinc(II) chloride (7646-85-7) → tetraaquabis(saccharinato)zinc(II) dihydrate

Conditions	Yield
In water under N2, C7H4NO3SNa*2H2O in water was added to aq. soln. of ZnCl2 (molar ratio 2.25:1) with stirring; cooled to 0°C for 1 h, filtered, washed with cold water, dried;	88%

trans dichlorobispyridine palladium (II) (14872-20-9, 15227-47-1, 14052-12-1) + sodium saccharinate dihydrate (6155-57-3) → trans-Pd(1,1-dioxo-1,2-benzothiazol-3-one(1-))2(pyridine)2 (1318240-28-6)

Conditions	Yield
With AgNO3 In water byproducts: AgCl; AgNO3 added to suspn. of Pd-complex in H2O, refluxed for 6 h, cooled to room temp., filtered, filtrate concd., Na-salt added, stirred at 60°C for 30 min, stirred at 60°C for 1 h, cooled to room temp.; filtered, recrystd. from DMSO; elem. anal.;	88%

dipyridil[3,2-a:2',3'-c]phenazine (19535-47-8) + copper(II) perchlorate hexahydrate + sodium saccharinate dihydrate (6155-57-3) → [Cu(dipyrido[3,2-a:2′,3′-c]phenazine)2(saccharinate)]ClO4

Conditions	Yield
Stage #1: copper(II) perchlorate hexahydrate; sodium saccharinate dihydrate In methanol for 2h; Stage #2: dipyridil[3,2-a:2',3'-c]phenazine In methanol at 60℃; for 4h;	88%

NH-pyrazole (288-13-1) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [Ag(saccharinate)(pyrazole)(H2O)]n (917837-18-4)

Conditions	Yield
In water; isopropyl alcohol; acetonitrile aq. soln. of Na salt mixed with soln. of AgNO3 in H2O-i-PrOH (1:3) with stirring, ppt. dissolved in MeCN and N compd. added; allowed to stand in dark at room temp. for 2 d; elem.anal;	87%

2-(aminoethyl)pyridine (2706-56-1) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → bis(2-(2-aminoethyl)pyridine)bis(saccharinato)disilver(I) (881006-83-3)

Conditions	Yield
In water; isopropyl alcohol 1 equiv. of NA-salt was dissolved in H2O and added to AgNO3 in H2O-iPrOH=1:3, v/v, mixt., 1 equiv. of amine was added, stirring at room temp. for 30 min; mixt. was allowed to stand in darkness at room temp. for a week, elem. anal.;	87%

1-piperidinoethanol (3040-44-6) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → Ag(saccharinate)(N-(2-hydroxyethylethyl)piperidine) (1130870-85-7)

Conditions	Yield
In water; acetonitrile 1 equiv. of Na-salt in H2O to aq. AgNO3 soln., MeCN was added until dissoln., 1 equiv. of piperidine-compd. was added; mixt. was allowed to stand at room temp. in the darkness for 2 d, elem. anal.;	87%

sodium saccharinate dihydrate (6155-57-3) + silver nitrate + 2,5-bis(2-pyridyl)-3,4-diaza-2,4-hexadiene → [Ag2(saccharinato)2(1,2-bis[1-(pyridin-2-yl)ethylidene]hydrazine)] (1226813-78-0)

Conditions	Yield
In further solvent(s) an aq. soln. of Na salt added to an aq. soln. of AgNO3, MeCN added, a MeOH soln. of ligand added dropwise, MeCN and i-PrOH added; crystd. in darkness at room temp. for 1 wk; elem. anal.;	87%

2-[(dimethylamino)methyl]pyridin-3-ol (2168-13-0) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [Ag(saccharate)(2-(dimethylaminomethyl)-3-hydroxypyridine)] (911321-27-2)

Conditions	Yield
In water; isopropyl alcohol a soln. of Na-saccharate in water was mixed with AgNO3 in water-2-propanol (1:3) with stirring, pyridine-compound was added, the mixt. was stirred for 30 min at room temp.; allowed to stand in darkness at room temp. for 4 days; elem. anal.;	86%

1,4-bis(2-hydroxyethyl)piperazine (122-96-3) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → [Ag(μ-saccharinato)(μ-N,N'-bis(2-hydroxyethyl)piperazine)](n)

Conditions	Yield
In water; isopropyl alcohol Na salt added to a soln. of AgNO3 in H2O and isopropanol, an aq. soln. of HOC2H4N(C2H4)2NC2H4OH added dropwise; crystd. for 4 d in the dark at room temp.; elem. anal.;	86%

cis-dichloro(2,2'-dipyridylamine)palladium(II) (111693-13-1) + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) → cis-[Pd(2,2'-dipyridylamine)(saccharinate)2]*H2O (1245815-85-3)

Conditions	Yield
With AgNO3 In water byproducts: AgCl; AgNO3 (1 mmol) added to aq. suspn. of PdCl2(dpya) (0.5 mmol), refluxed for 6 h, cooled to room temp., AgCl filtered off, concd., Na(sac)*2H2O (1mmol) added, mixt. stirred at 60°C for 30 min; ppt. filtered off, recrystd. (H2O/DMF=1/1), elem. anal.;	86%

(2-aminomethylpyridine) (3731-51-9) + sodium saccharinate dihydrate (6155-57-3) + silver nitrate → 2-(aminomethyl)pyridinesaccharinatosilver(I) (881006-82-2)

Conditions	Yield
In water; isopropyl alcohol 1 equiv. of NA-salt was dissolved in H2O and added to AgNO3 in H2O-iPrOH=1:3, v/v, mixt., 1 equiv. of amine was added, stirring at room temp. for 30 min; mixt. was allowed to stand in darkness at room temp. for a week, elem. anal.;	85%

sodium saccharinate dihydrate (6155-57-3) + silver nitrate + N,N-dimethylethylenediamine (108-00-9) → bis(N,N-dimethylethylenediamine)bis(saccharinato)disilver(I)

Conditions	Yield
In water; isopropyl alcohol Na salt added to soln. of AgNO3 in H2O-iPrOH (1:3), diamine added to suspn.; evapd. slowly at room temp., stand for 2 wk; elem. anal.;	85%

di(pyridin-2-yl)amine (1202-34-2) + cis-dichloro(2,2'-dipyridylamine)palladium(II) (111693-13-1) + water (7732-18-5) + sodium saccharinate dihydrate (6155-57-3) → [Pd(2,2'-dipyridylamine)]2[saccharinate]2*2H2O

Conditions	Yield
In methanol; water aq. suspn. of PdCl2(dpya) (0.5 mmol) mixed with MeOH soln. of ligand (1 mmol), refluxed overnight, cooled to room temp., filtered, aq. soln. of Na(sac)*2H2O (1 mmol) added, mixt. stirred at 60°C for 2 h; concd., crystd. in 1 d, elem. anal.;	85%

chloro(bis(2-pyridylmethyl)amine)palladium(II) chloride monohydrate (439120-09-9) + sodium saccharinate dihydrate (6155-57-3) → [Pd(bis(2-pyridylmethyl)amine)(saccharinato)](saccharinate)*2H2O

Conditions	Yield
With AgNO3 In water byproducts: AgCl; Pd-complex and solid AgNO3 were added to water and set to reflux for 6 h, AgCl was filtered, the filtrate was concd. and Na-saccharate was added, stirred at 60°C for 30 min; stand for 1 d; elem. anal.;	85%

Downstream Products

• 6639-62-9 methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide 
• 1473399-44-8 [Ag₂(saccharinate)₂(μ-1,1-bis(diphenylphosphino)methane)H₂O]*H₂O 
• 1473399-51-7 [Ag₂(μ-saccharinate)₂(μ-1,2-bis(diphenylphosphino)butane)]_n 
• 59826-54-9 N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2(3H)-acetamide 1,1-dioxide 
• 930301-72-7 Ag(saccharinato)(S,S-diphenylsulfimide)