60986-77-8

Basic information

• Product Name: 5-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-3-phenyl-isoxazole-4-carboxylic acid methylamide
• CAS NO: 60986-77-8
• Molecular Weight: 350.374
• Mol File: 60986-77-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-3-phenyl-isoxazole-4-carboxylic acid methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-3-phenyl-isoxazole-4-carboxylic acid methylamide(60986-77-8)
• EPA Substance Registry System: 5-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-3-phenyl-isoxazole-4-carboxylic acid methylamide(60986-77-8)

Safety Data

• Hazardous Substances Data: 60986-77-8(Hazardous Substances Data)

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 16883-16-2 5-methyl-3-phenylisoxazole-4-carbonyl chloride 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 60986-88-1 N,5-dimethyl-3-phenyl-isoxazole-4-carboxamide 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 

Relevant articles and documents

Identification of a series of highly potent activators of the Nurr1 signaling pathway

The nuclear receptor Nurr1 (NR4A2) is critically involved in the development and maintenance of midbrain dopaminergic neurons and is believed to function independently of endogenous activation. The hit identification and SAR studies leading to isoxazolo-pyridinone 7e, a highly potent, brain penetrable activator of the Nurr1 signaling pathway, are described.