52898-49-4

Basic information

• Product Name: 4,N-DIMETHOXY-N-METHYLBENZAMIDE
• Synonyms: 4,N-DIMETHOXY-N-METHYLBENZAMIDE;4-Methoxy-N-Methoxy-N-MethylbenzaMide
• CAS NO: 52898-49-4
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 52898-49-4.mol
• Article Data: 73

Chemical Properties

• Boiling Point: 105°C/0.1mmHg(lit.)
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.114 g/cm³
• Vapor Pressure: 6.1E-05mmHg at 25°C
• Refractive Index: 1.5440 to 1.5480
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4,N-DIMETHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,N-DIMETHOXY-N-METHYLBENZAMIDE(52898-49-4)
• EPA Substance Registry System: 4,N-DIMETHOXY-N-METHYLBENZAMIDE(52898-49-4)

Safety Data

• Hazardous Substances Data: 52898-49-4(Hazardous Substances Data)

Usage

General Description

4,N-Dimethoxy-N-methylbenzamide is a chemical compound with the molecular formula C10H13NO3. It is a benzamide derivative with two methoxy groups and one methyl group attached to the benzene ring. This chemical is commonly used in pharmaceutical research as an intermediate for the synthesis of various organic compounds. It is also used as a building block for the preparation of various pharmaceuticals and agrochemicals. Additionally, it is utilized in the production of dyes, perfumes, and other organic compounds. The compound has potential applications in medicinal chemistry, and it is being studied for its biological and pharmacological properties.

InChI:InChI=1/C10H13NO3/c1-11(14-3)10(12)8-4-6-9(13-2)7-5-8/h4-7H,1-3H3

Upstream product

• 2614-48-4 N-methyl-N-(4-methoxybenzoyl)hydroxylamine 
• 6214-19-3 methyl p-methoxybenzenesulfonate 
• 100-09-4 4-methoxybenzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 53875-17-5 C₉H₁₀NO₃^(1-) 
• 33613-52-4 dimethylphenyl sulfonium tetrafluoroborate 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 30289-28-2 N-methoxy-N-methylcarbamoyl chloride 
• 100-07-2 4-methoxy-benzoyl chloride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 223570-55-6 N-methoxy-N-methyl-2-pyridyl urethane 
• 29829-22-9 S-methyldibenzothiophenium tetrafluoroborate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 121-98-2 methyl 4-methoxybenzoate 

Downstream Products

• 147030-66-8 3-(1,3-dioxolan-2-yl)-4'-methoxypropiophenone 
• 1671-76-7 p-Methoxyvalerophenon 
• 4160-63-8 2-(4-methoxybenzoyl)thiophene 
• 60986-77-8 5-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-3-phenyl-isoxazole-4-carboxylic acid methylamide 
• 937791-08-7 C₁₈H₂₅NO₅ 
• 132160-44-2 6-(4-hydroxybenzoyl)-5-(4-hydroxyphenyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione 
• 175791-64-7 2,4-Dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone 
• 175791-65-8 5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone 
• 175791-66-9 2,4-Dimethoxy-5-(4-methoxyphenyl)pyrrolo<2,3-d>pyrimidine-6-yl 4-methoxyphenyl ketone 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 1125674-13-6 (5-bromo-2-fluoropyridin-3-yl)(4-methoxyphenyl)methanone 
• 79574-74-6 (2-fluoropyridin-3-yl)(4-methoxyphenyl)methanone 
• 108837-29-2 5-methoxy-2-(4-methoxybenzoyl)-benzoic acid 
• 1158955-22-6 C₁₃H₉F₂NO₂ 

Relevant articles and documents

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes

An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph