54364-85-1

Basic information

• Product Name: 4-oxo-4-(2-phenoxyphenyl)butyric acid
• CAS NO: 54364-85-1
• Molecular Weight: 270.285
• Mol File: 54364-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-oxo-4-(2-phenoxyphenyl)butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4-(2-phenoxyphenyl)butyric acid(54364-85-1)
• EPA Substance Registry System: 4-oxo-4-(2-phenoxyphenyl)butyric acid(54364-85-1)

Safety Data

• Hazardous Substances Data: 54364-85-1(Hazardous Substances Data)

Upstream product

• 26388-13-6 1-(2-phenoxyphenyl)ethan-1-one 

Downstream Products

• 906560-17-6 5-(2-phenoxyphenyl)-3H-furan-2-one 
• 906560-22-3 4-oxo-4-(2-phenoxy-phenyl)-butyraldehyde 
• 906560-20-1 2-(2-phenoxyphenyl)pyrrole 

Relevant articles and documents

Facile synthesis of 2-arylpyrroles from 4-oxo-butanoic acids and their use in the preparation of bis(pyrrolyl)methanes

A range of 3-aroyl-propionic acids have been cyclised to unsaturated lactones which, upon reduction using DIBAL-H and reaction with an ammonia source, gave 2-arylpyrroles (Ar = Ph, 1-naphthyl, o-phenoxyphenyl and 4-methyl-2-methylsulfanylphenyl) in excellent yields. Reaction of 2,6-disubstituted aroylpropanals (Ar = 2,4,6-Me3C6H2, anthracenyl and 2-Me-naphthalen-1-yl) with an ammonia source failed to generate pyrroles. The arylpyrroles react readily with ketones or aldehydes in ethanol or under eutectic mix melt conditions to give bis-(pyrrolyl)methanes in excellent isolated yields.