26388-13-6

Basic information

• Product Name: 1-(2-PHENOXYPHENYL)ETHANONE
• Synonyms: 1-(2-PHENOXYPHENYL)ETHANONE
• CAS NO: 26388-13-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 26388-13-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 132 °C
• Flash Point: 131.672 °C
• Appearance: /
• Density: 1.108 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-(2-PHENOXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-PHENOXYPHENYL)ETHANONE(26388-13-6)
• EPA Substance Registry System: 1-(2-PHENOXYPHENYL)ETHANONE(26388-13-6)

Safety Data

• Hazardous Substances Data: 26388-13-6(Hazardous Substances Data)

Usage

Description

1-(2-PHENOXYPHENYL)ETHANONE is an organic compound with the chemical structure consisting of a phenyl group connected to a phenoxy group, which is further attached to an ethanone (ketone) group. It is known for its potential applications in various industries due to its unique chemical properties.

Uses

1. Used in Pharmaceutical Industry:
1-(2-PHENOXYPHENYL)ETHANONE is used as a reactant for the preparation of imidazo[1,2-a]pyrazines. These compounds serve as inhibitors of bacterial type IV secretion, which is a crucial mechanism for bacterial pathogenesis. By inhibiting this secretion system, imidazo[1,2-a]pyrazines can potentially be used to treat bacterial infections caused by pathogens that rely on type IV secretion.
2. Used in Chemical Synthesis:
1-(2-PHENOXYPHENYL)ETHANONE can be utilized as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile building block in organic chemistry.
3. Used in Research and Development:
Due to its potential applications in different fields, 1-(2-PHENOXYPHENYL)ETHANONE may be employed in research and development laboratories to explore new chemical reactions, synthesize novel compounds, and study its properties for potential commercial applications.

InChI:InChI=1/C14H12O2/c1-11(15)13-9-5-6-10-14(13)16-12-7-3-2-4-8-12/h2-10H,1H3

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 100-67-4 potassium phenolate 
• 108-95-2 phenol 
• 445-27-2 2'-Fluoroacetophenone 
• 445-26-1 1-(2-fluorophenyl)ethanol 
• 446-52-6 2-Fluorobenzaldehyde 
• 101-84-8 diphenylether 
• 64-19-7 acetic acid 

Downstream Products

• 83537-25-1 ethyl trans-3-(2-phenoxybenzoyl)glycidate 
• 1415829-93-4 2-azido-1-(2-phenoxyphenyl)ethanone 
• 1415829-95-6 2-azido-1-(2-phenoxyphenyl)ethanol 
• 1415829-97-8 2-amino-1-(2-phenoxyphenyl)ethanol 
• 1415829-99-0 2-[(3-chloropyrazin-2-yl)amino]-1-(2-phenoxyphenyl)ethanol 
• 1415830-01-1 2-[(3-chloropyrazin-2-yl)amino]-1-(2-phenoxyphenyl)ethanone 
• 1415830-02-2 8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine 
• 1415829-36-5 4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide 
• 1415830-35-1 8-chloro-2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine 
• 1415829-47-8 4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide 
• 54364-85-1 4-oxo-4-(2-phenoxyphenyl)butyric acid 
• 906560-17-6 5-(2-phenoxyphenyl)-3H-furan-2-one 
• 906560-22-3 4-oxo-4-(2-phenoxy-phenyl)-butyraldehyde 

Relevant articles and documents

Monodisperse CuPd alloy nanoparticles as efficient and reusable catalyst for the C (sp2)–H bond activation

Metal-catalyzed selective activation of C–H bonds is very important for the construction of a variety of biologically active molecules. Supported alloy nanoparticles are of great interest in various catalytic applications due to the synergistic effects between different metals. Here, well-dispersed CuPd alloy nanoparticles supported on reduced graphene oxide (rGO) were synthesized and found to be highly efficient and recyclable catalyst for the chelation-assisted C (sp2)–H bond activation. Aromatic ketones or esters were synthesized via the cross-dehydrogenative coupling (CDC) reaction between 2-arylpyridines and alcohols or acids. Moreover, the catalyst was recovered and used for five times without significantly losing activity.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

Graphene oxide grafted with Pd17Se15 nano-particles generated from a single source precursor as a recyclable and efficient catalyst for C-O coupling in O-arylation at room temperature

The Pd17Se15 nanoparticles, synthesized for the first time from a single source precursor [Pd(L)Cl2] {L = 1,3-bis(phenylselenyl)propan-2-ol} and grafted onto graphene oxide, show high catalytic activity in C-O coupling between aryl/heteroaryl chlorides/bromides and phenol at room temperature (Pd loading 1 mol%; yield up to 94%).