52568-28-2

Basic information

• Product Name: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE
• Synonyms: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE;alpha,alpha-DiMethyl-2-pyridineMethanaMine;2-(2-Pyridyl)-2-propylaMine;2-(Pyridin-2-yl)propan-2-aMine;[(E)-N-(1-(6-((Di-tert-butylphosphino)oxy)-pyridin-2-yl)ethylidene)-2,6-diisopropylaniline]iron dichloride;2-(Pyridin-2-yl)isopropyl amine;Huang hydrosilylation catalyst;2-(Pyridin-2-yl)isopropyl amine 95% (GC)
• CAS NO: 52568-28-2
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19428
• Mol File: 52568-28-2.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 212.7±15.0 °C(Predicted)
• Flash Point: 79℃
• Appearance: /
• Density: 0.9800 g/mL at 25℃
• Refractive Index: n/D1.516
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.40±0.50(Predicted)
• CAS DataBase Reference: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE(52568-28-2)
• EPA Substance Registry System: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE(52568-28-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 52568-28-2(Hazardous Substances Data)

Usage

Uses

The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale.

General Description

2-(Pyridin-2-yl)isopropyl amine (PIP-amine) is a tertiary amine. A bidentate directing group, useful for the functionalization of C-H bond, has been developed from PIP-amine.

Upstream product

• 100-70-9 2-Cyanopyridine 
• 75-16-1 methylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 1192356-19-6 (1-methyl-1-pyridin-2-ylethyl)carbamic acid tert-butyl ester 
• 917-54-4 methyllithium 

Downstream Products

• 1357775-91-7 C₂₆H₃₀N₄ 
• 1620193-47-6 2-methyl-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 
• 1620193-55-6 3-fluoro-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 
• 1620193-53-4 4-chloro-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 

Relevant articles and documents

Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)-H Bonds: Scope and Mechanistic Studies

The synthesis of fluorinated complex molecules via direct C(sp3)-H fluorination is attractive yet remains challenging. Here we describe the Pd(II)-catalyzed fluorination of unactivated methylene C(sp3)-H bonds by an inner-sphere mech

Copper-Mediated Thiolation of Unactivated Heteroaryl C?H Bonds with Disulfides under Ligand- and Metal-Oxidant-Free Conditions

Various sulfenylated heteroarenes were synthesized by a copper-mediated C?H thiolation, which was assisted by a 2-(pyridin-2-yl)isopropylamine (PIP-amine) directing group. The reaction features a broad substrate scope, good functional group tolerance, ligand- and metal-oxidant-free conditions, exceptional compatibility with aliphatic disulfides, and excellent yields, providing a highly efficient approach to the biologically important sulfenylated heteroarenes. (Figure presented.).

HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS

Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in onco

Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent

The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.