[1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE

Base Information

• Chemical Name: [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE
• CAS No.: 52568-28-2
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• Mol file: 52568-28-2.mol

Synonyms:[1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE

Chemical Property of [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE

Chemical Property:

• Refractive Index: n/D1.516
• Boiling Point: 212.7±15.0 °C(Predicted)
• PKA: 9.40±0.50(Predicted)
• Flash Point: 79℃
• PSA: 38.91000
• Density: 0.9800 g/mL at 25℃
• LogP: 1.97570
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Pyridyl)-2-propylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Uses: The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale.

Technology Process of [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE

There total 6 articles about [1-METHYL-1-(PYRIDIN-2-YL)ETHYL]AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + methyllithium (917-54-4) → 2-(pyridin-2-yl)isopropyl amine (52568-28-2)

Guidance literature:

methyllithium; With cerium(III) chloride; In tetrahydrofuran; diethyl ether; at -76 - -60 ℃;

2-Cyanopyridine; In tetrahydrofuran; diethyl ether; at -76 - 15 ℃;

Reference yield: 82.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + methylmagnesium bromide (75-16-1) → 2-(pyridin-2-yl)isopropyl amine (52568-28-2)

Guidance literature:

In 2-methyltetrahydrofuran; toluene; at 0 ℃; for 18h; Reflux;

DOI:10.1002/ejoc.201501300

Reference yield: 57.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + methyl magnesium iodide (917-64-6) → 2-(pyridin-2-yl)isopropyl amine (52568-28-2)

Guidance literature:

In toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/ejic.201600540

upstream raw materials:

2-Cyanopyridine

methyllithium

methylmagnesium bromide

(1-methyl-1-pyridin-2-ylethyl)carbamic acid tert-butyl ester

Downstream raw materials:

(1-methyl-1-pyridin-2-ylethyl)carbamic acid tert-butyl ester

N-[(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-2-ylethylamino)propyl]-5-piperidin-1-yl-N',N'-dipropylisophthalamide

Refernces

• 1、 Zhan, Bei-Bei,Liu, Yan-Hua,Hu, Fang,Shi, Bing-Feng. "Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C-H bonds with lithium halides using a removable auxiliary". . p. 4934 - 4937. Retrieved 2016.
• 2、 -. "5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF". Paragraph 00495-00498. . Retrieved 2021/04/10.
• 3、 Donslund, Aske S.,Neumann, Karoline T.,Corneliussen, Nicklas P.,Grove, Ebbe K.,Herbstritt, Domenique,Daasbjerg, Kim,Skrydstrup, Troels. "Access to β-Ketonitriles through Nickel-Catalyzed Carbonylative Coupling of α-Bromonitriles with Alkylzinc Reagents". supporting information. p. 9856 - 9860. Retrieved 2019/07/09.