4452-13-5

Basic information

• Product Name: (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one
• Synonyms: 1-Phenyl-3-(3-pyridinyl)-2-propen-1-one
• CAS NO: 4452-13-5
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.2432
• Mol File: 4452-13-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 181°C
• Density: 1.143g/cm³
• Vapor Pressure: 1.87E-05mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one(4452-13-5)
• EPA Substance Registry System: (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one(4452-13-5)

Safety Data

• Hazardous Substances Data: 4452-13-5(Hazardous Substances Data)

Usage

General Description

(2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one, also known as β-pyridyl-α-phenylacrolein, is a chemical compound with the molecular formula C16H11NO. It is a yellow-brown crystalline solid that is used in organic synthesis and pharmaceutical research. (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one has been studied for its potential medicinal properties, including its role as a potential anti-cancer agent and its ability to inhibit the growth of certain bacteria and fungi. It is also used as a reagent in the synthesis of various organic compounds, and its structure allows for multiple potential chemical modifications to tailor its properties for specific applications. Additionally, it is used as a flavoring or scent agent due to its aromatic properties. Overall, (2E)-1-phenyl-3-pyridin-3-ylprop-2-en-1-one is a versatile compound with various potential applications in the fields of medicine, chemistry, and industry.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 100-55-0 3-hydroxymethylpyridin 

Downstream Products

• 39976-56-2 1-phenyl-3-(pyridin-3-yl)propan-1-one 
• 100881-32-1 4-phenyl-6-(pyridin-3-yl)pyrimidin-2-amine 
• 66702-71-4 1-phenyl-3-pyridin-3-yl-prop-2-en-1-ol 
• 27046-82-8 3-(5-phenyl-1-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-pyridine 
• 1446393-63-0 C₁₉H₁₆N₂ 
• 1446393-61-8 2-phenyl-4-(3-pyridyl)-5,6,7,8-tetrahydroquinoline 
• 1416219-39-0 (3S,4S)-3-benzyl-6-phenyl-4-(pyridin-3-yl)-3,4-dihydro-2H-pyran-2-one 

Relevant articles and documents

Regiodivergent synthesis of vinyl trifluoromethansulfonates γ/δ lactones: Via 1,6 addition/intramolecular one-pot annulation of 1,4-dihidropyridines derivated from pyridinyl propenones

We report a novel intramolecular 1,6 oxa-Michael addition on substituted dihydropyridines to obtain 5 and 6 member ring lactones in an one-pot reaction starting from activated pyridinyl propenones, without organic catalysis or presence of bulky groups in

Potassium Base-Catalyzed Michael Additions of Allylic Alcohols to α,β-Unsaturated Amides: Scope and Mechanistic Insights

We report herein the first KHMDS-catalyzed Michael additions of allylic alcohols to α,β-unsaturated amides through allylic isomerization. The reaction proceeds smoothly in the presence of only 5 mol% of KHMDS to afford a variety of 1,5-ketoamides in high yields. Mechanistic investigations, including experimental and computational studies, reveal that the KHMDS-catalyzed in-situ generation of the enolate from the allylic alcohol through a tunneling-assisted 1,2-hydride shift is the key to the success of this transformation. (Figure presented.).

Combination of the Claisen-Schmidt reaction, the Michael addition, and the Hantzsch reaction in the synthesis of 2,6′-bis-aryl-3,4′-bipyridines

Pyridine-3-carbaldehyde reacted with 1-(aryl)ethan-1-ones to give 1,5-diaryl-3-(pyridin-3-yl)pentane-1,5-diones, which were further converted to 2′,6′-bis-aryl-3,4′-bipyridines.