1416219-39-0Relevant articles and documents
Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis
Mo, Junming,Yang, Ruojie,Chen, Xingkuan,Tiwari, Bhoopendra,Chi, Yonggui Robin
supporting information, p. 50 - 53 (2013/03/14)
A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.