4211-87-4Relevant articles and documents
Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines
Sarkar, Debayan,Sahoo, Sushree Ranjan
, p. 2035 - 2049 (2019/03/07)
A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b
Clean and efficient synthesis of isoxazole derivatives in aqueous media
Dou, Guolan,Xu, Pan,Li, Qiang,Xi, Yukun,Huang, Zhibin,Shi, Daqing
, p. 13645 - 13653 (2014/01/06)
A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild rea
RING TRANSFORMATION REACTION OF 1,4,6-TRISUBSTITUTED 2(1H)-PYRIMIDINONES AND -THIONES WITH HYDROXYLAMINE
Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
, p. 2516 - 2519 (2007/10/02)
1,4,6-Trisubstituted 2(1H)-pyrimidinones (Ia-e) underwent ring transformation with hydroxylamine to afford 3,5-disubstituted isoxazoles (IIa-e) in high yields.On the other hand, 2(1H)-pyrimidinethiones (IIIa, b, f-k) underwent ring transformation to give mainly a new type of N-substituted 2-aminopyrimidine 1-oxides (IVa, b, f-k) as well as isoxazoles.The reaction of pyrimidinium salts (VII, VIII, and IX) with hydroxylamine is also discussed.Keywords: - ring tranformation reaction; hydroxylamine; nucleophilic reaction; 3,5-disubstituted isoxazoles; N-substituted 2-aminopyrimidine 1-oxides; pyrimidinium salts