- Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines
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A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b
- Sarkar, Debayan,Sahoo, Sushree Ranjan
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p. 2035 - 2049
(2019/03/07)
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- An efficient synthesis of isoxazoles and pyrazoles under ultrasound irradiation
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A series of 5-arylisoxazole and 5-aryl-1H-pyrazole derivatives was synthesized by the reaction of 3-(dimethylamino)-1-arylprop-2-en-1-one with hydroxylamine hydrochloride or hydrazine hydrate under ultrasound irradiation without using any catalyst. This m
- Huang, Zhi-Bin,Li, Li-Li,Zhao, Yan-Wei,Wang, Hui-Yuan,Shi, Da-Qing
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p. E309-E313
(2014/11/07)
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- Clean and efficient synthesis of isoxazole derivatives in aqueous media
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A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild rea
- Dou, Guolan,Xu, Pan,Li, Qiang,Xi, Yukun,Huang, Zhibin,Shi, Daqing
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p. 13645 - 13653
(2014/01/06)
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- Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes
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The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline
- Alberola, Angel,Banez, J. Manuel,Calvo, Luis,Rodriguez, M. Teresa Rodriguez,Sanudo, M. Carmen
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p. 467 - 471
(2007/10/02)
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- RING TRANSFORMATION REACTION OF 1,4,6-TRISUBSTITUTED 2(1H)-PYRIMIDINONES AND -THIONES WITH HYDROXYLAMINE
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1,4,6-Trisubstituted 2(1H)-pyrimidinones (Ia-e) underwent ring transformation with hydroxylamine to afford 3,5-disubstituted isoxazoles (IIa-e) in high yields.On the other hand, 2(1H)-pyrimidinethiones (IIIa, b, f-k) underwent ring transformation to give mainly a new type of N-substituted 2-aminopyrimidine 1-oxides (IVa, b, f-k) as well as isoxazoles.The reaction of pyrimidinium salts (VII, VIII, and IX) with hydroxylamine is also discussed.Keywords: - ring tranformation reaction; hydroxylamine; nucleophilic reaction; 3,5-disubstituted isoxazoles; N-substituted 2-aminopyrimidine 1-oxides; pyrimidinium salts
- Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
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p. 2516 - 2519
(2007/10/02)
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