41564-67-4

Basic information

• Product Name: (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone
• Synonyms: (E)-1,3-Bis(4-methoxyphenyl)-2-propene-1-one;(E)-4,4'-Dimethoxychalcone;(E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone;4,4'-Dimethoxy-trans-chalcone;(2E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one;1,3-bis(4-methoxyphenyl)-2-propen-1-one
• CAS NO: 41564-67-4
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Mol File: 41564-67-4.mol
• Article Data: 76

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone(41564-67-4)
• EPA Substance Registry System: (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone(41564-67-4)

Safety Data

• Hazardous Substances Data: 41564-67-4(Hazardous Substances Data)

Usage

Description

(E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone, commonly known as curcumin III, is a naturally occurring chemical compound belonging to the curcuminoid class. It is derived from the turmeric plant and has garnered significant attention for its potential therapeutic properties, which include antioxidant, anti-inflammatory, anticancer, neuroprotective, and antidiabetic effects. The unique chemical structure and diverse biological activities of curcumin III render it a promising candidate for pharmaceutical and medicinal research and applications.

Uses

Used in Pharmaceutical Applications:
(E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone is used as a therapeutic agent for its antioxidant and anti-inflammatory properties, which can help alleviate various health conditions and promote overall well-being.
Used in Anticancer Applications:
In the field of oncology, (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone is used as an anticancer agent, targeting a wide range of cancer types. Its potential to modulate multiple oncological signaling pathways and demonstrate synergistic effects when combined with conventional chemotherapeutic drugs makes it a valuable asset in the fight against cancer.
Used in Neuroprotective Applications:
(E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone is used as a neuroprotective agent, offering potential benefits for individuals suffering from neurodegenerative diseases or conditions that affect the nervous system.
Used in Antidiabetic Applications:
In the context of diabetes management, (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone is used as an antidiabetic agent, potentially aiding in the regulation of blood sugar levels and improving overall metabolic health.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone, it is used in conjunction with various drug delivery systems, such as organic and metallic nanoparticles, to improve its delivery and efficacy in targeted applications.
Used in the Food Industry:
(E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone, as a component of turmeric, is used as a natural coloring agent and flavor enhancer in the food industry, adding a vibrant yellow hue and unique taste to various dishes and products.
Used in Cosmetic Applications:
In the cosmetics industry, (E)-β-(4-Methoxyphenyl)-4'-methoxyacrylophenone is used for its antioxidant and anti-inflammatory properties, which can help improve skin health, reduce inflammation, and protect against environmental stressors.

Upstream product

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Downstream Products

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• 88827-44-5 4,6-Bis(4-methoxyphenyl)-2-methylpyridine 
• 140885-62-7 4,6-bis(4-methoxyphenyl)-2-methylpyridine-3-carbonitrile 
• 144309-62-6 (4S,5R)-5-(4-Methoxy-benzoyl)-4-(4-methoxy-phenyl)-1-p-tolyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 144309-70-6 (4S,5R)-1-(4-Chloro-phenyl)-5-(4-methoxy-benzoyl)-4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 23073-04-3 2,4-bis(4-methoxyphenyl)-4-oxobutanenitrile 
• 4741-73-5 1,3-bis(4-methoxyphenyl)propane 
• 444315-42-8 1,3-di(4'-methoxyphenyl)hexane-1,4-dione 
• 444315-43-9 1,3-di(4'-methoxyphenyl)heptane-1,4-dione 
• 84703-10-6 2,4-bis-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-2-chromen 
• 5884-18-4 3-indol-3-yl-1,3-bis-(4-methoxy-phenyl)-propan-1-one 

Relevant articles and documents

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Alkene Synthesis by Photo-Wolff-Kischner Reaction of Sulfur Ylides and N-Tosylhydrazones

A visible-light-driven and room temperature photo-Wolff-Kischner reaction of sulfur ylides and N-tosylhydrazones has been developed for the first time to provide modular access to alkene synthesis. The high functional group tolerance and broad substrate scope were demonstrated by more than 60 examples. Both E- and Z-olefinic stereochemistry in the products could be controlled with excellent stereoselectivity. A series of mechanistic studies support that the reaction should proceed through a radical-carbanion crossover pathway, specifically involving addition of photo-generated sulfur ylide radical cations to N-tosylhydrazones to form carbanions and subsequent Wolff-Kischner process.

Method using Ti (III) complex catalytic alkyne selective hydrogenation reduction to prepare chalcone compounds

The invention discloses a method for preparing chalcone compounds through selective hydrogenation of Ti (III) complexes to prepare chalcone compounds, wherein zinc powder is used as a catalyst, zinc powder is a reducing agent, triethylamine hydrochloride is a proton source, and an alkyne and triethylamine hydrochloride are subjected to radical selective addition reaction under the protection of inert gas to generate chalcone compounds. The reaction condition is mild, the operation is simple, the reaction time is short, the reaction product is single, the atom economy is high, and only the product needs to be separated by simple column chromatography after the reaction is finished. The chalcone compound has wide biological activity and medicinal value.