385425-15-0

Basic information

• Product Name: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
• Synonyms: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE;1-(4-Iodophenyl)-2-piperidinone;Apixaban II;2-Piperidinone,1-(4-iodophenyl)-
• CAS NO: 385425-15-0
• Molecular Formula: C₁₁H₁₂INO
• Molecular Weight: 301.12355
• Mol File: 385425-15-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 446.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.670
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.43±0.20(Predicted)
• CAS DataBase Reference: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE(385425-15-0)
• EPA Substance Registry System: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE(385425-15-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 385425-15-0(Hazardous Substances Data)

Usage

General Description

1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE is a chemical compound which is characterized by a piperidinone molecule substituted with an iodophenyl group at the 1-position. The substitution of iodine on the phenyl ring enhances its biological activity, making it useful in pharmaceutical applications. 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE is frequently involved in the synthesis of high value-added and bio-active molecules. However, detailed information about its safety, toxicity, and specific applications is limited and further research is needed in order to fully understand this particular compound's properties and potential uses.

Upstream product

• 2067-33-6 5-bromopentanoic acid 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 4096-20-2 N-phenyl piperidine 
• 540-37-4 p-aminoiodobenzene 
• 4509-90-4 5-bromovaleroyl chloride 

Downstream Products

• 473927-69-4 1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 
• 872882-96-7 1-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-piperidin-2-one 
• 503614-92-4 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid 
• 545445-44-1 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone 
• 503614-91-3 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 
• 280118-23-2 1-(3-amino-benzo[d]isoxazol-5-yl)-6-[2'-(3-hydroxy-pyrrolidin-1-ylmethyl)-biphenyl-4-yl]-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 
• 280118-23-2 BMS-740808 

Relevant articles and documents

Pyrazolo [3, 4 - c] pyridine - 7 - ketone compound and use thereof

Belonging to the technical field of medicine, the invention relates to a 4, 5-dihydro-1H-pyrazolo[3, 4-c]pyridine-7-one containing derivative shown as general formula I, and pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein the substituents A, R1 and R2 have meanings given in the specification. The preparation also relates to a preparation method of the general formula I compound and its pharmaceutically acceptable salt or prodrug, medicinal compositions containing the compound and application of the compound as an Xa factor inhibitor, especially application in preparation of drugs for treatment and/or prevention of thromboembolic diseases. (formula I).

PROCESS FOR THE PREPARATION OF APIXABAN

The present invention relates to an improved process for the preparation of Apixaban and its intermediates.

Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams

A metal-free strategy for the formation of lactams via selective oxidation of cyclic secondary and tertiary amines is described. Molecular iodine facilitates both chemoselective and regioselective oxidation of C-H bonds directly adjacent to a cyclic amine. The mild conditions, functional group tolerance, and substrate scope are demonstrated using a suite of diverse small molecule cyclic amines, including clinically approved drug scaffolds.