2067-33-6Relevant articles and documents
Preparation method of 5- bromo-n-valeryl bromide
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Paragraph 0017; 0019; 0021; 0028; 0032, (2019/12/25)
The invention relates to a preparing method of 5-bromine pivaloyl bromide normal, belonging to the field of synthesizing methods of compounds. The preparing method of the 5-bromine pivaloyl bromide normal comprises the following steps: (1) synthesis of a midbody I: adding raw materials, i.e. m-chloroperoxybenzoic acid and drying chloroform, into a reaction kettle, and slowly adding a drying chloroform solution containing raw material cyclopentanone at room temperature so as to obtain a crude product of the midbody I; (2) synthesis of a midbody II: adding the raw material midbody I, hydrobromicacid and sodium bromide into the reaction kettle, reacting to obtain the midbody II and directly carrying out the reaction of a next step without purification; (3) synthesis of the 5-bromine pivaloylbromide normal: adding triphenylphosphine and dichloromethane into the reaction kettle, reducing the temperature to about 0 DEG C, starting to slowly add a dichloromethane solution containing bromine, adding the raw material midbody II to react, and purifying to obtain a target product, i.e. the 5-bromine pivaloyl bromide normal. The prepared product prepared by the method has higher purity and ideal yield coefficient and is suitable for being applied to industrialized production.
A aldehyde or mellow directly converted into the carboxylic acid (by machine translation)
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Paragraph 0044-0046, (2018/08/03)
The invention discloses a aldehyde or mellow oxidation can be directly transformed into carboxylic acid, is characterized in that the pure oxygen environment, in N - hydroxy imide compound under the catalysis of the imide compound or N - hydroxy and nitrous acid ester compound common under the catalysis, the CH2 OH and CHO oxidation directly converted into the carboxylic acid compounds. The invention using oxygen as the oxidizing agent, does not add any metal catalyst, environment-friendly, high catalytic efficiency, simple and convenient operation. With the previous metal catalytic system complex and different catalytic system, has some metal catalytic system in the process, the use of transition metal will cause the transition metal of the residual, the invention adopts the non-metallic catalytic system, environmental protection, preventing the metal residue problem, this to the solution of the drug in the synthesis of transition metal residue problem and provides a new method of thinking. (by machine translation)
Preparation method of 5-bromo-valeric acid
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Paragraph 0097; 0098; 0099; 0100, (2016/11/28)
The invention relates to a preparation method of 5-bromo-valeric acid. The preparation method particularly includes: subjecting 5-chlorine-3-pentenoic acid ester to hydrolysis reaction, hydrogenation reaction and bromination reaction to obtain 5-bromo-valeric acid, wherein 5-chlorine-3-pentenoic acid ester is one of or multiple of 5-chlorine-3-pentenoic acid methyl ester, 5-chlorine-3-pentenoic acid ethyl ester, 5-chlorine-3-pentenoic acid propyl ester and 5-chlorine-3-pentenoic acid butyl ester. The preparation method is high in finished product yield, low in production cost, simple and easy to control and easy for industrial production, and using of high-toxicity substances like benzene and sodium cyanide is avoided, so that safety is high.