3471-31-6 Usage
Description
5-Methoxyindole-3-acetic acid is an organic compound that serves as a chemical reagent in various applications, including the synthesis of different types of inhibitors and antagonists, as well as the analysis of physiological properties of auxins.
Uses
Used in Pharmaceutical Industry:
5-Methoxyindole-3-acetic acid is used as a reactant for the preparation of aryloxybenzothiazoles, which act as inhibitors of NO production, helping in the development of treatments for various inflammatory and cardiovascular conditions.
5-Methoxyindole-3-acetic acid is also used as a reactant for the preparation of transcription inhibitors of novel Gli1, which have potential applications as antitumor agents, targeting specific cancer-related pathways.
Used in Neuropharmacology:
5-Methoxyindole-3-acetic acid is used as a reactant for the preparation of indole derivatives, which function as NR2B/NMDA receptor antagonists. These compounds have potential applications in the treatment of neurological disorders, such as Alzheimer's disease and schizophrenia.
Used in Anti-inflammatory Drug Development:
5-Methoxyindole-3-acetic acid is used as a reactant for the preparation of indolyl esters and amides related to indomethacin, which are selective COX-2 inhibitors. These compounds have potential applications in the development of anti-inflammatory drugs with reduced side effects.
Used in Immunology:
5-Methoxyindole-3-acetic acid is used as a reactant for the preparation of quinoline salicylic acid series of P-selectin antagonists. These compounds have potential applications in the treatment of inflammatory and autoimmune diseases by modulating cell adhesion and leukocyte recruitment.
Used in Prostaglandin Research:
5-Methoxyindole-3-acetic acid is used as a reactant for the preparation of prostaglandin D2 receptor antagonists. These compounds have potential applications in the treatment of allergic diseases, such as asthma and allergic rhinitis, by modulating the effects of prostaglandin D2.
Used in Plant Physiology Research:
5-Methoxyindole-3-acetic acid is used as a chemical reagent in the analysis of the physiological properties of auxins, which are plant hormones that regulate growth and development. This application aids in understanding the mechanisms of plant growth and the development of new agricultural technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 3471-31-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,7 and 1 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3471-31:
(6*3)+(5*4)+(4*7)+(3*1)+(2*3)+(1*1)=76
76 % 10 = 6
So 3471-31-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO3/c1-15-8-2-3-10-9(5-8)7(6-12-10)4-11(13)14/h2-3,5-6,12H,4H2,1H3,(H,13,14)/p-1
3471-31-6Relevant articles and documents
Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst
Egami, Hiromichi,Hotta, Ryo,Otsubo, Minami,Rouno, Taiki,Niwa, Tomoki,Yamashita, Kenji,Hamashima, Yoshitaka
, p. 5656 - 5660 (2020/07/14)
Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.
A substituted indole -3 - acetic acid synthesis method (by machine translation)
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Paragraph 0074, (2017/05/02)
The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)
Erythropoietin Expression Promoter
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, (2015/12/30)
The present invention provides an erythropoietin expression-enhancing agent that can cancel the suppression of erythropoietin production or promote erythropoietin production, and a therapeutic or preventive drug for anemia, a liver function-improving agent, an ischemic injury-improving agent, a renal protective agent, and an insulin secretagogue comprising the erythropoietin expression-enhancing agent. The erythropoietin expression-enhancing agent of the present invention comprises one or more compounds selected from the group consisting of compounds represented by the following general formulas (I), (II), and (III) and pharmaceutically acceptable salts thereof when R3 is OH.
