34133-58-9

Basic information

• Product Name: 2,4-DIAMINO-PHENOL
• Synonyms: 2,4-DIAMINO-PHENOL;2,4-Dicyanophenol;4-Hydroxyisophthalonitrile;1,3-Benzenedicarbonitrile,4-hydroxy-;FeBuxostat Impurity 35
• CAS NO: 34133-58-9
• Molecular Formula: C₈H₄N₂O
• Molecular Weight: 124.14052
• Mol File: 34133-58-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 319℃
• Flash Point: 150℃
• Appearance: /
• Density: 1.34
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.04±0.18(Predicted)
• CAS DataBase Reference: 2,4-DIAMINO-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIAMINO-PHENOL(34133-58-9)
• EPA Substance Registry System: 2,4-DIAMINO-PHENOL(34133-58-9)

Safety Data

• Hazardous Substances Data: 34133-58-9(Hazardous Substances Data)

Usage

Description

2,4-DIAMINO-PHENOL, also known as 2,4-diaminophenol, is an organic compound with the molecular formula C6H8N2O. It is a white or light gray crystalline solid that is soluble in water and ethanol. 2,4-DIAMINO-PHENOL is characterized by the presence of two amino groups (-NH2) at the 2nd and 4th positions of a phenol molecule (C6H4OH). Due to its unique chemical structure, 2,4-DIAMINO-PHENOL exhibits various chemical and biological properties, making it a versatile compound for different applications.

Uses

Used in Pharmaceutical Industry:
2,4-DIAMINO-PHENOL is used as an intermediate in the synthesis of various pharmaceutical compounds. It serves as a building block for the production of drugs that target specific diseases and conditions. One such application is in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout. Febuxostat helps to lower uric acid levels in the blood, providing relief from the symptoms associated with these conditions.
Used in Chemical Synthesis:
2,4-DIAMINO-PHENOL is also used as a chemical intermediate in the synthesis of various organic compounds, including dyes, pigments, and polymers. Its reactivity with other chemical groups allows for the formation of a wide range of products with diverse applications in the chemical industry.
Used in Analytical Chemistry:
Due to its ability to form complexes with metal ions, 2,4-DIAMINO-PHENOL is employed as a reagent in analytical chemistry for the detection and quantification of certain metal ions. This property makes it useful in various analytical techniques, such as spectrophotometry and chromatography, where the detection and measurement of metal ions are crucial.
Used in Research and Development:
2,4-DIAMINO-PHENOL is utilized in research and development for the study of its chemical properties, reactivity, and potential applications in various fields. Researchers use this compound to explore new synthetic routes, develop novel materials, and investigate its biological activities, which could lead to the discovery of new drugs or other useful products.

InChI:InChI=1/C8H4N2O/c9-4-6-1-2-8(11)7(3-6)5-10/h1-3,11H

Upstream product

• 23731-06-8 5-(chloromethyl)salicylaldehyde 
• 3328-70-9 5-formyl-2-hydroxybenzaldehyde 
• 90-02-8 salicylaldehyde 
• 615-58-7 2,4-dibromophenol 
• 619-72-7 4-nitrobenzonitrile 
• 22433-92-7 2,4-dicyano-1-methoxybenzene 
• 52054-41-8 4-nitroisophthalonitrile 
• 36914-79-1 acetic acid 2,4-dibromophenyl ester 
• 151-50-8 potassium cyanide 
• 67-56-1 methanol 
• 1885-29-6 anthranilic acid nitrile 
• 94353-39-6 2,4-dicyanophenyl acetate 
• 62-53-3 aniline 
• 4387-30-8 4-chloro-1,3-benzenedicarbonitrile 

Downstream Products

• 54176-51-1 5-bromo-4-hydroxyisophthalic acid dimethyl ester 
• 1342299-81-3 6-(methoxycarbonyl)chroman-8-carboxylic acid 
• 95088-64-5 3-bromo-2-hydroxy-5-(methoxycarbonyl)benzoic acid 
• 1342299-76-6 C₁₆H₁₃BrO₅ 
• 1342299-77-7 C₁₉H₁₇BrO₅ 
• 1342299-78-8 C₁₈H₁₆O₅ 
• 1342299-79-9 C₂₁H₂₀O₅ 
• 1342299-80-2 C₁₉H₁₆O₅ 
• 1342299-85-7 C₁₈H₁₅BrO₆ 
• 1342299-86-8 C₂₁H₂₀O₆ 
• 5383-97-1 5-Allyl-4-hydroxy-isophthalsaeure-dimethylester 
• 13253-23-1 3-Carboxy-4-hydroxy-5-allyl-benzoesaeure-methylester 
• 1342299-87-9 C₁₉H₁₈O₅ 
• 1342299-88-0 C₂₂H₂₂O₅ 

Relevant articles and documents

The Synthesis and Transition Temperatures of Ester Derivatives of 2-Fluoro-4-hydroxy- and 3-Fluoro-4-hydroxybenzonitriles also Incorporating Aliphatic Ring Systems

The synthesis and liquid-crystal transition temperatures of forty ester derivatives of 2-fluoro-4-hydroxybenzonitrile and 3-fluoro-4-hydroxybenzonitrile are reported.The esters contain the trans-1,4-disubstituted cyclohexane or the 1,4-disubstituted bicyclooctane rings (some contain an additional phenyl ring).Many of the novel F-substituted esters exhibit substantially higher nematic-isotropic transition temperatures than the corresponding unsubstituted esters.The order of clearing points of these laterally substituted esters differing only in the presence of a benzene ring and the above-mentioned rings is established.

Preparation method and use of 2-phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivative

The invention belongs to the technical field of medicines, and relates to a preparation method and a use of a 2-phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivative. The invention provides the 2-phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivative represented by general formula I, or a pharmaceutically acceptable salt, an isomer, a polymorph and a medicinal solvate thereof, and further provides an intermediate for preparing the 2-phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivative or the pharmaceutically acceptable salt thereof. The structure of the intermediate is representedby general formula II, III or IV; and in the formulas, R, R and R are as defined in claims and the description.

COMPOUNDS CONTAINING FUSED RINGS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.