3328-70-9

Basic information

• Product Name: 4-HYDROXYISOPHTHALALDEHYDE
• Synonyms: BUTTPARK 85\50-29;2,4-DIFORMYLPHENOL;4-HYDROXYISOPHTHALALDEHYDE;5-FORMYL-2-HYDROXYBENZALDEHYDE;5-FORMYLSALICYLALDEHYDE;TIMTEC-BB SBB004073;4-HYDROXYISOPHTHALALDEHYDE 98+%;4-Hydroxyisophthaladehyde
• CAS NO: 3328-70-9
• Molecular Formula: C₈H₆O₃
• Molecular Weight: 150.13
• Mol File: 3328-70-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 109°C
• Boiling Point: 266 °C at 760mmHg
• Flash Point: 128.9 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.00538mmHg at 25°C
• Refractive Index: 1.672
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 5.98±0.18(Predicted)
• CAS DataBase Reference: 4-HYDROXYISOPHTHALALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYISOPHTHALALDEHYDE(3328-70-9)
• EPA Substance Registry System: 4-HYDROXYISOPHTHALALDEHYDE(3328-70-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 3328-70-9(Hazardous Substances Data)

Usage

Description

4-Hydroxyisophthalaldehyde (4-HIPA) is a versatile aldehyde compound characterized by the presence of a hydroxyl group at the 4 position on its aromatic ring. It is renowned for its reactivity and serves as a crucial starting material in the synthesis of a variety of pharmaceuticals, agrochemicals, and organic compounds. The unique structure of 4-HIPA allows it to participate in multiple chemical reactions, including condensation, oxidation, and reduction, leading to the formation of a broad spectrum of functionalized derivatives. Its value in the chemical industry is further enhanced by its potential role in the development of new materials and its application in catalysis.

Uses

Used in Pharmaceutical Industry:
4-Hydroxyisophthalaldehyde is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its reactivity to form complex organic molecules that possess therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-HIPA is utilized as a starting material for the production of compounds that contribute to crop protection and enhancement of agricultural yields.
Used in Organic Compounds Synthesis:
4-Hydroxyisophthalaldehyde serves as a building block in the synthesis of diverse organic compounds, capitalizing on its ability to undergo a range of chemical reactions to create functionalized derivatives.
Used in Material Development:
4-HIPA is employed in the development of new materials, taking advantage of its unique chemical properties to engineer innovative substances with specialized applications.
Used in Catalysis:
As a component in catalytic processes, 4-Hydroxyisophthalaldehyde contributes to the efficiency and selectivity of chemical reactions, further expanding its utility in the chemical industry.

InChI:InChI=1/C8H6O3/c9-4-6-1-2-8(11)7(3-6)5-10/h1-5,11H

Upstream product

• 23731-06-8 5-(chloromethyl)salicylaldehyde 
• 67-66-3 chloroform 
• 123-08-0 4-hydroxy-benzaldehyde 
• 90-02-8 salicylaldehyde 
• 74901-08-9 5-hydroxymethylsalicylaldehyde 
• 7697-37-2 nitric acid 
• 404354-44-5 3-formyl-4-hydroxybenzoyl chloride 
• 50-00-0 formaldehyd 
• 64-19-7 acetic acid 
• 108-95-2 phenol 
• 100-97-0 hexamethylenetetramine 
• 1761-62-2 5-iodosalicyclaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 20200-69-5 6-formyl-1',3',3'-trimethylspiro<2H-1-benzopyran-2,2'-<1H>-indole> 

Downstream Products

• 857477-51-1 5-chloromethyl-4-hydroxy-isophthalaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 186093-84-5 2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-carbaldehyde 
• 120973-73-1 2-(3-chlorobenzoyl)-5-formylbenzofuran 
• 1372604-81-3 C₁₇H₁₁N₃O₂ 
• 1372604-83-5 C₁₇H₉N₃O₂ 
• 1389379-99-0 4-hydroxy-3-((2-hydroxyphenylimino)methyl)benzaldehyde 
• 1312698-60-4 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)benzyl)oxy)benzene-1,3-dicarbaldehyde 
• 1241371-43-6 C₂₂H₁₆N₂O₄ 
• 1241371-41-4 C₁₈H₁₆N₂O₄ 

Relevant articles and documents

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A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective

Synthesis, characterization, and UV–visible study of some new photochromic formyl-containing 1′,3′,3′-trimethylspiro[chromene-2,2′-indoline] derivatives

The spiropyran derivatives can exist in two forms, the closed-ring spiropyran form and the open-ring merocyanine (MC) form. The SP form could be converted into the MC form upon UV irradiation. In this work, some 1′,3′,3′-trimethylspiro[chromene-2,2′-indoline] derivatives containing the nitro and formyl groups are synthesized via the reaction of 1,3,3-trimethyl-2-methylene-5-nitroindoline with the corresponding salicylaldehyde derivatives. These compounds have different photochromic behaviors. The synthesized photochromic molecules are characterized by the FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. In order to investigate the photochromic properties of these compounds, the UV–visible spectroscopic analyses of their methanolic solutions before and after exposure to a UV lamp (in the spectral range of 360–400?nm) are studied. Graphic abstract: [Figure not available: see fulltext.].

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)

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