3247-75-4Relevant articles and documents
Studies on drug metabolism by use of isotopes. XXVI. Determination of urinary metabolites of rutin in humans
Baba,Furuta,Horie,Nakagawa
, p. 780 - 782 (1981)
Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d3 in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and β-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in the urine.
Studies on drug metabolism by use of isotopes. XXVII: Urinary metabolites of rutin in rats and the role of intestinal microflora in the metabolism of rutin
Baba,Furuta,Fukioka,Goromaru
, p. 1155 - 1158 (1983)
Analysis of urinary metabolites of orally administered rutin (I) labeled with deuterium ([2,5',6'-2H]rutin, rutin-d) was carried out by GLC-MS. In rat urine, 3-hydroxyphenylacetic acid (III), 3-methoxy-4-hydroxyphenylacetic acid (IV), 3,4-dihydroxyphenylacetic acid (V), 3,4-dihydroxytoluene (VI), and 3-(m-hydroxyphenyl)propionic acid (VIII) were identified as rutin metabolites and were differentiated from the corresponding endogeneous compounds. Unchanged I and quercetin (II) were not present in the urine. Rutin-d was injected intraperitoneally in rats, administered orally to neomycin-treated rats, and incubated in vitro with the intestinal contents of rats. The experiments suggested the involvement of intestinal microflora in the metabolism of orally administered I.