3247-75-4

Basic information

• Product Name: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid
• Synonyms: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid;3-(3-Hydroxyphenyl)-3-hydroxypropionic;3-hydroxy-3-(3-hydroxyphenyl)propanoic acid;3-hydroxy-3-(3-hydroxyphenyl)propionic acid;β-(M-Hydroxyphenyl)hydracrylic Acid;3-(3-Hydroxyphenyl)-3-hydroxypropionic acid;3-(3-Hydroxyphenyl)hydracrylic acid;beta-(m-Hydroxyphenyl)hydracrylic acid
• CAS NO: 3247-75-4
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.17
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 3247-75-4.mol

Chemical Properties

• Melting Point: 159℃ (decomposition)
• Boiling Point: 421.665 °C at 760 mmHg
• Flash Point: 222.962 °C
• Appearance: /
• Density: 1.401 g/cm³
• Vapor Pressure: 7.29E-08mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated), Water
• CAS DataBase Reference: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid(3247-75-4)
• EPA Substance Registry System: 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid(3247-75-4)

Safety Data

• Hazardous Substances Data: 3247-75-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid is used as a pharmaceutical compound for its potential health benefits. As a urinary metabolite of phenylalanine and Rutin, it may contribute to the maintenance of capillary health and the regulation of phenylalanine metabolism in the body.
Used in Research Applications:
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid is used as a research compound for studying its properties, potential applications, and interactions with biological systems. Its unique structure and functional groups make it a valuable tool for investigating various biological processes and mechanisms.

InChI:InChI=1/C9H10O4/c10-7-3-1-2-6(4-7)8(11)5-9(12)13/h1-4,8,10-11H,5H2,(H,12,13)

Upstream product

• 87877-89-2 β-m-benzyloxyphenylhydracrylic acid 

Downstream Products

• 3247-75-4 (R)-3-hydroxy-3-(3-hydroxy-phenyl)-propionic acid 
• 17430-96-5 (S)-3-hydroxy-3-(3-hydroxy-phenyl)-propionic acid 

Relevant articles and documents

Studies on drug metabolism by use of isotopes. XXVI. Determination of urinary metabolites of rutin in humans

Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d3 in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and β-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in the urine.

Studies on drug metabolism by use of isotopes. XXVII: Urinary metabolites of rutin in rats and the role of intestinal microflora in the metabolism of rutin

Analysis of urinary metabolites of orally administered rutin (I) labeled with deuterium ([2,5',6'-2H]rutin, rutin-d) was carried out by GLC-MS. In rat urine, 3-hydroxyphenylacetic acid (III), 3-methoxy-4-hydroxyphenylacetic acid (IV), 3,4-dihydroxyphenylacetic acid (V), 3,4-dihydroxytoluene (VI), and 3-(m-hydroxyphenyl)propionic acid (VIII) were identified as rutin metabolites and were differentiated from the corresponding endogeneous compounds. Unchanged I and quercetin (II) were not present in the urine. Rutin-d was injected intraperitoneally in rats, administered orally to neomycin-treated rats, and incubated in vitro with the intestinal contents of rats. The experiments suggested the involvement of intestinal microflora in the metabolism of orally administered I.