31529-46-1

Basic information

• Product Name: 2-Methylindolin-1-amine
• Synonyms: 2-METHYL-INDOL-1-YLAMINE;2-Methylindolin-1-amine;2,3-dihydro-2-methyl-1h-indol-1-amine;2-METHYLINDOLIN-1-AMINE 98.0+% OFF WHITE TO SLIGHTLY RED POWDER;2-Methyl-2,3-dihydro-1H-indole-1-amine;2-Methylindoline-1-amine;(2-methylindolin-1-yl)amine;2-methyl-2,3-dihydroindol-1-amine
• CAS NO: 31529-46-1
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.2
• EINECS: 250-683-6
• Product Categories: Indoles and derivatives
• Mol File: 31529-46-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 41 °C
• Boiling Point: 256.9 °C at 760 mmHg
• Flash Point: 130.2 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.579
• PKA: 5.04±0.40(Predicted)
• CAS DataBase Reference: 2-Methylindolin-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylindolin-1-amine(31529-46-1)
• EPA Substance Registry System: 2-Methylindolin-1-amine(31529-46-1)

Safety Data

• Hazardous Substances Data: 31529-46-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Methylindolin-1-amine is used as a key intermediate in the synthesis of pharmaceutical drugs due to its unique molecular structure and potential medicinal properties. Its presence in the molecular framework of drugs can contribute to their therapeutic effects, making it a valuable component in drug development.
Used in Agrochemical Production:
In the agrochemical industry, 2-Methylindolin-1-amine is utilized as a building block for the creation of various agrochemicals. Its incorporation into these compounds can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Organic Synthesis as a Catalyst:
2-Methylindolin-1-amine is also being investigated for its potential use as a catalyst in organic synthesis reactions. Its amine functionality can facilitate certain types of chemical transformations, making it a promising candidate for improving the efficiency and selectivity of various synthetic processes.
Used in Research and Development:
2-Methylindolin-1-amine is employed in research settings to explore its potential role in the treatment of various diseases. Ongoing studies aim to understand its mechanism of action and optimize its therapeutic potential, which could lead to the development of new medications and treatment strategies.

InChI:InChI=1/C9H12N2/c1-7-6-8-4-2-3-5-9(8)11(7)10/h2-5,7H,6,10H2,1H3

Upstream product

• 6872-06-6 2-methyl indoline 
• 2950-43-8 hydroxylamine-O-sulfonic acid 
• 85440-79-5 1-nitroso-2-methylindoline 

Downstream Products

• 26807-65-8 Indapamide 

Relevant articles and documents

1-[(imidazolin-2-yl)amino]indoline and 1-[(imidazolin-2-yl)amino]1,2,3,4-tetrahydroquinoline derivatives: New insights into their circulatory activities

N-[(Imidazolin-2-yl)amino]indolines and N-[(imidazolin-2-yl)amino]-1,2,3,4-tetrahydroquinolines, previously described in patent literature as hypertensive agents, were synthesized and tested in vitro for their affinities to α1- and α2-adrenoceptors as well as imidazoline I1 and I2 receptors. The compounds most potent at either α1- or α2-adrenoceptors were administered intravenously to normotensive Wistar rats to determine their effects on mean arterial blood pressure and heart rate. Upon intravenous administration at dose of 0.1 mg/kg to normotensive male Wistar rats, the initial transient pressor effect was followed by long-lasting hypotension and bradycardia. In view of the above results the 1-[(imidazolin-2-yl)amino]indolines and [(imidazolin-2-yl)amino]-1,2,3,4-tetrahydroquinolines are now found to possess circulatory profile characteristic of the centrally acting clonidine-like hypotensive imidazolines.

1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds

Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom,R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond,R1, R2, R3 and R4 represent a hydrogen or halogen atom,an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups,R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group,X and Y represent a hydrogen atom or an alkyl group,Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain,Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

Synthesis of 1-amino-2-methylindoline by Raschig process: Parallel reactions, modeling, and optimization

The reaction between chloramine and 2-methylindoline was studied at pH 12.89, T = 40°C, and for different initial concentrations of reactants. The interaction includes two concurrent bimolecular mechanisms leading to 1-amino-2-methylindoline and 2-methyli

Synthesis method for solution with high grade chloramine

The present invention relates to a process for the preparation of high-grade chloramine by the action of commercial eau de Javelle of 100 chlorometric degrees on a solution of ammonia in the presence of ammonium chloride. According to this process, the chloramine is obtained having a content greater than or equal to 2 mol L?1, that is to say, greater than or equal to 10.3%. The process can be carried out continuously or discontinuously.

Preparation of 4-chloro-3-sulphamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-benzamide from 2,3-dihydro-2-methyl-1H-indole and hydroxylamine-O-sulphonic acid

The invention relates to a new process for the industrial preparation of 4-chloro-3-sulphamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide from 2,3-dihydro-2-methyl-1H-indole and hydroxylamine-O-sulphonic acid.

Preparation of N-amino compounds

Disclosed is a method of preparing N-amino compounds from corresponding secondary amines by reacting a secondary amine with nitrous acid and zinc in a neutral pH reaction media to form the corresponding N-amine.