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2950-43-8

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2950-43-8 Usage

Description

Hydroxylamine-O-sulfonic acid (HOSA) is a versatile synthetic reagent that is widely employed as both a nucleophile and an electrophile in various organic syntheses. It is a white to slightly beige crystalline powder and can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.

Uses

Used in Pharmaceutical Synthesis:
Hydroxylamine-O-sulfonic acid is used as a key intermediate in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as an aminating reagent in the synthesis of various pharmaceutical compounds, including 1-aminotetrazoles, 2-aminotetrazoles, N-aminopiperidine (NAPP), and 1H,1′ H-2,2′-biimidazole-1,1′-diamine.
Used in Polymerization:
Hydroxylamine-O-sulfonic acid serves as a polymerization catalyst, facilitating the formation of polymers in various industrial applications.
Used in Chemical Reactions:
HOSA is involved in the preparation of diazene by reacting with an alkali, which is useful in various chemical processes.
Used in Environmental Applications:
Hydroxylamine-O-sulfonic acid is used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated biphenyl (PCB) formation in co-combustion processes, contributing to a cleaner and more sustainable environment.

Purification Methods

Stir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]

Check Digit Verification of cas no

The CAS Registry Mumber 2950-43-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,5 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2950-43:
(6*2)+(5*9)+(4*5)+(3*0)+(2*4)+(1*3)=88
88 % 10 = 8
So 2950-43-8 is a valid CAS Registry Number.
InChI:InChI=1/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4)

2950-43-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (H0530)  Hydroxylamine-O-sulfonic Acid  >90.0%(T)

  • 2950-43-8

  • 25g

  • 690.00CNY

  • Detail
  • TCI America

  • (H0530)  Hydroxylamine-O-sulfonic Acid  >90.0%(T)

  • 2950-43-8

  • 100g

  • 1,890.00CNY

  • Detail
  • TCI America

  • (H0530)  Hydroxylamine-O-sulfonic Acid  >90.0%(T)

  • 2950-43-8

  • 500g

  • 4,980.00CNY

  • Detail
  • Alfa Aesar

  • (A12560)  Hydroxylamine-O-sulfonic acid, 97%   

  • 2950-43-8

  • 25g

  • 924.0CNY

  • Detail
  • Alfa Aesar

  • (A12560)  Hydroxylamine-O-sulfonic acid, 97%   

  • 2950-43-8

  • 100g

  • 2602.0CNY

  • Detail
  • Sigma-Aldrich

  • (213136)  Hydroxylamine-O-sulfonicacid  97%

  • 2950-43-8

  • 213136-25G

  • 1,213.29CNY

  • Detail
  • Sigma-Aldrich

  • (213136)  Hydroxylamine-O-sulfonicacid  97%

  • 2950-43-8

  • 213136-100G

  • 3,534.57CNY

  • Detail
  • Sigma-Aldrich

  • (55493)  Hydroxylamine-O-sulfonicacid  purum, ≥95.0% (RT)

  • 2950-43-8

  • 55493-25G

  • 1,420.38CNY

  • Detail
  • Sigma-Aldrich

  • (55493)  Hydroxylamine-O-sulfonicacid  purum, ≥95.0% (RT)

  • 2950-43-8

  • 55493-100G

  • 4,111.38CNY

  • Detail
  • Sigma-Aldrich

  • (227978)  Hydroxylamine-O-sulfonicacid  technical grade, 90%

  • 2950-43-8

  • 227978-25G

  • 896.22CNY

  • Detail
  • Sigma-Aldrich

  • (227978)  Hydroxylamine-O-sulfonicacid  technical grade, 90%

  • 2950-43-8

  • 227978-100G

  • 2,555.28CNY

  • Detail
  • Aldrich

  • (480975)  Hydroxylamine-O-sulfonicacid  99.999%

  • 2950-43-8

  • 480975-5G

  • 614.25CNY

  • Detail

2950-43-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name amino hydrogen sulfate

1.2 Other means of identification

Product number -
Other names Sulfamic acid N-oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2950-43-8 SDS

2950-43-8Relevant articles and documents

Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors

Liu, Bin,Yuan, Xia,Xu, Bo,Zhang, Han,Li, Ridong,Wang, Xin,Ge, Zemei,Li, Runtao

, p. 1 - 15 (2019/03/17)

Multiple lines of evidence have indicated that pyruvate kinase M2 (PKM2) is upregulated in most cancer cells and it is increasingly recognized as a potential therapeutic target in oncology. In a continuation of our discovery of lead compound 5 and SAR study, the 7-azaindole moiety in compound 5 was systematically optimized. The results showed that compound 6f, which has a difluoroethyl substitution on the 7-azaindole ring, exhibited high PKM2 activation potency and anti-proliferation activities on A375 cell lines. In a xenograft mouse model, oral administration of compound 6f led to significant tumor regression without obvious toxicity. Further mechanistic studies revealed that 6f could influence the translocation of PKM2 into nucleus, as well as induction of apoptosis and autophagy of A375 cells. More importantly, compound 6f significantly inhibited migration of A375 cells in a concentration-dependent manner. Collectively, 6f may serve as a lead compound in the development of potent PKM2 activators for cancer therapy.

Method for the production of O-substituted hydroxylamines

-

, (2008/06/13)

A new method for the production of O-substituted hydroxylamines is disclosed. Hydroxylamine-O-sulfonic acid is reacted with alkali alkoxide in the presence of a polar aprotic solvent.

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