2950-43-8 Usage
Description
Hydroxylamine-O-sulfonic acid (HOSA) is a versatile synthetic reagent that is widely employed as both a nucleophile and an electrophile in various organic syntheses. It is a white to slightly beige crystalline powder and can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.
Uses
Used in Pharmaceutical Synthesis:
Hydroxylamine-O-sulfonic acid is used as a key intermediate in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as an aminating reagent in the synthesis of various pharmaceutical compounds, including 1-aminotetrazoles, 2-aminotetrazoles, N-aminopiperidine (NAPP), and 1H,1′ H-2,2′-biimidazole-1,1′-diamine.
Used in Polymerization:
Hydroxylamine-O-sulfonic acid serves as a polymerization catalyst, facilitating the formation of polymers in various industrial applications.
Used in Chemical Reactions:
HOSA is involved in the preparation of diazene by reacting with an alkali, which is useful in various chemical processes.
Used in Environmental Applications:
Hydroxylamine-O-sulfonic acid is used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated biphenyl (PCB) formation in co-combustion processes, contributing to a cleaner and more sustainable environment.
Purification Methods
Stir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]
Check Digit Verification of cas no
The CAS Registry Mumber 2950-43-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,5 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2950-43:
(6*2)+(5*9)+(4*5)+(3*0)+(2*4)+(1*3)=88
88 % 10 = 8
So 2950-43-8 is a valid CAS Registry Number.
InChI:InChI=1/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4)
2950-43-8Relevant articles and documents
Multigram Synthesis of Functionalized Spirocyclic Diazirines
Martyloga, Oleksandr V.,Myronenko, Artamon,Tkachenko, Anton M.,Matvienko, Vitalii O.,Kuchkovska, Yuliya O.,Grygorenko, Oleksandr O.
, p. 3744 - 3750 (2019/06/28)
An approach to the synthesis of spirocyclic diazirines from cyclic ketones was examined on a series of carbo- and heterocyclic substrates containing the amine or carboxylic acid moiety. A mini-library of stereochemically diverse functionalized spirocyclic diazirines was synthesized on a multigram scale with 30–81 % yield.
Method for the production of O-substituted hydroxylamines
-
, (2008/06/13)
A new method for the production of O-substituted hydroxylamines is disclosed. Hydroxylamine-O-sulfonic acid is reacted with alkali alkoxide in the presence of a polar aprotic solvent.
