306-44-5 Usage
Description
ISONITROSOACETONE, also known as (E)-2-oxopropanal oxime, is an organic compound that serves as a versatile intermediate in the synthesis of various organic and pharmaceutical compounds. It is characterized by its reactivity and ability to form a wide range of products, making it a valuable asset in the fields of research and development, as well as in the production of pharmaceuticals and chemicals.
Uses
Used in Organic Synthesis:
ISONITROSOACETONE is used as an organic synthesis intermediate for its ability to react with a variety of reagents, leading to the formation of diverse organic compounds. This makes it a valuable tool in the development of new chemical entities and the improvement of existing ones.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, ISONITROSOACETONE is used as a pharmaceutical intermediate. Its reactivity allows for the creation of various drug candidates, which can then be further developed and optimized for specific therapeutic applications.
Used in Laboratory Research and Development:
ISONITROSOACETONE is also utilized in laboratory research and development processes, where it can be employed to explore new reaction pathways, develop novel synthetic methods, and investigate the properties of newly synthesized compounds.
Used in Pharmaceutical and Chemical Production Processes:
Finally, ISONITROSOACETONE is used in the production processes of pharmaceuticals and chemicals. Its versatility as an intermediate allows for the efficient synthesis of a wide range of products, contributing to the advancement of both industries.
Preparation
To a well-stirred, ice-cooled solution of 5.8 gm (0.1 mole) of acetone in 30 ml of glacial acetic acid is added dropwise a concentrated aqueous solution containing 15 gm of sodium nitrite. Stirring at 0°C is continued for 45 min, then 100 ml of water is added and the crude product is extracted with ether.
The ether extracts are combined, washed repeatedly with 10 ml portions of water, and dried with sodium sulfate. The ether is evaporated off under reduced pressure and the residue is dried on a porous plate. After recrys-tallization from benzene, 6 gm (69%) of the product is isolated, m.p. 65°C.
Synthesis
under the condition of the ice, to 1000 ml three port successively added in the bottle KOH (58.35g, 1 . 16eq, 1 . 04mol) and 585 ml water, the reaction system is cooled to 0 °C, adding to the reaction system (103.61g, 1eq, 0.892mol), after stirring at room temperature add 24h; once again the reaction system is cooled to 0 °C, in the reaction system by adding NaNO2(71.76g, 1 . 16eq, 1 . 04mol), the reaction system to maintain 0 °C, to wherein the dropwise H2SO4(50%), the for PH 4-5 (adding sulphuric acid to the volume to the final system is PH), stir at room temperature 2h, this will produce a large amount of gas in the process, a white precipitate, then in to the system by adding NaOH (35%) solution, the for PH 9-10, finally in the reaction system by adding 100 ml of toluene, the organic phase and aqueous phase separation, is added to the aqueous phase H2SO4(50%) the adjusted to PH 5-6, ethyl acetate (3*100 ml) extraction, anhydrous sodium sulfate for drying, can be obtained turns on lathe does white solid 61 . 3g (yield 79%).
Check Digit Verification of cas no
The CAS Registry Mumber 306-44-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 306-44:
(5*3)+(4*0)+(3*6)+(2*4)+(1*4)=45
45 % 10 = 5
So 306-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO2/c1-3(5)2-4-6/h2,6H,1H3/b4-2+
306-44-5Relevant articles and documents
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Singer,Vamplew
, p. 3052 (1957)
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Involvement of the Enol Tautomers in the Nitrosation of Ketones
Leis, J. Ramon,Pena, M. Elena,Williams, D. Lyn H.
, p. 45 - 47 (1987)
Nitrosation of ketones involves reaction of the enol form; the rate limiting step can be either formation of the enol, or its reaction with the nitrosating agent.
Sterilization compound and preparation method and application thereof
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Paragraph 0021; 0047; 0048; 0049, (2016/10/27)
The invention relates to the field of agricultural plant protection, and particularly relates to a sterilization compound and a preparation method and an application thereof. The compound has the structure represented by a formula defined in the specification, wherein R is selected from one of components defined in the specification; the compound has excellent bacteriostatic activity on potato phytophthora infestans, phytophthora capsici, phytophthora nicotianae, peronophthora litchii, pseudoperonospora cubensis and other plant pathogenic oomycetes, and has broad application prospects in prevention and control of oomycete diseases.
Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis
Campeau, Louis-Charles,Stuart, David R.,Leclerc, Jean-Philippe,Bertrand-Laperle, Megan,Villemure, Elisia,et al.
supporting information; experimental part, p. 3291 - 3306 (2009/07/30)
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