30273-11-1

Basic information

• Product Name: 4-SEC-BUTYLANILINE
• Synonyms: 4-sec-butylbenzenamine;4-sec-Butylaniline;4-SEC-BUTYLANILINE;4-(2-BUTYL)ANILINE;AKOS BBS-00003701;4-(1-methylpropyl)-benzenamin;4-(1-methylpropyl)-Benzenamine;4-Amino-sec-butylbenzene
• CAS NO: 30273-11-1
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.23
• EINECS: 250-108-9
• Mol File: 30273-11-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 1.08°C (estimate)
• Boiling Point: 244-245 °C727 mm Hg(lit.)
• Flash Point: 226 °F
• Appearance: /
• Density: 0.977 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0308mmHg at 25°C
• Refractive Index: n20/D 1.537(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.02±0.10(Predicted)
• CAS DataBase Reference: 4-SEC-BUTYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-SEC-BUTYLANILINE(30273-11-1)
• EPA Substance Registry System: 4-SEC-BUTYLANILINE(30273-11-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 30273-11-1(Hazardous Substances Data)

Usage

Description

4-SEC-BUTYLANILINE, also known as 4-(1-Methylpropyl)aniline, is an organic compound with the chemical formula C10H15N. It is a derivative of aniline, where a 1-methylpropyl group is attached to the 4-position of the aniline molecule. 4-SEC-BUTYLANILINE is characterized by its amine and methyl groups, which contribute to its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
4-SEC-BUTYLANILINE is used as a reagent in the preparation of [dimethyl(dioxo)purinyl]alkanecarboxamides. These compounds serve as multifunctional TRPA1 antagonists and PDE4/7 inhibitors, which have potential therapeutic applications in the treatment of various types of pain. By targeting these specific receptors and enzymes, 4-SEC-BUTYLANILINE plays a crucial role in the development of novel pain management medications.

InChI:InChI=1/C10H15N/c1-3-8(2)9-4-6-10(11)7-5-9/h4-8H,3,11H2,1-2H3

Upstream product

• 30273-11-1 4-sec-butylaniline 
• 513-48-4 2-butyl iodide 
• 540-37-4 p-aminoiodobenzene 
• 92100-30-6 p-nitro-sec-butylbenzene 
• 135-98-8 sec-Butylbenzene 
• 4237-40-5 1-(iso-propyl)-4-nitrobenzene 
• 62-53-3 aniline 
• 78-92-2 iso-butanol 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 

Downstream Products

• 135-98-8 sec-Butylbenzene 
• 88329-16-2 4-(sec-butyl)-N,N-dimethylaniline 
• 30273-11-1 (+)-4-sec-butyl-aniline 
• 30273-11-1 (-)-4-sec-butyl-aniline 
• 211558-24-6 (4-sec-Butyl-phenylamino)-acetonitrile 
• 171764-73-1 4-sec-butylphenyl cyanamide 
• 171767-35-4 N,N'-di-(4-sec-butylphenyl)guanidine 
• 65442-31-1 6-sec-butylquinoline 
• 1082515-66-9 3-(4-bromophenyl)-4-(4-sec-butylphenyl)-5-phenyl-4H-1,2,4-triazole 
• 1219438-79-5 1-[4-(2-butyl)phenyl]-3-hydroxy-2-methyl-4(1H)-pyridinone 
• 128034-00-4 C₁₃H₂₀N₂O 
• 171764-79-7 N,N'-bis(4-sec-Butylphenyl)-N-methyl guanidine.HCl 

Relevant articles and documents

Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides

A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.(Figure Presented)

9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines

A series of 9-(substituted amino)imidazo[4,5-f]quinolines are effective anthelmintic agents; particularly in respect to the tapeworm Hymenolepis nana.