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4-SEC-BUTYLANILINE, also known as 4-(1-Methylpropyl)aniline, is an organic compound with the chemical formula C10H15N. It is a derivative of aniline, where a 1-methylpropyl group is attached to the 4-position of the aniline molecule. 4-SEC-BUTYLANILINE is characterized by its amine and methyl groups, which contribute to its chemical properties and potential applications.

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  • 30273-11-1 Structure
  • Basic information

    1. Product Name: 4-SEC-BUTYLANILINE
    2. Synonyms: 4-sec-butylbenzenamine;4-sec-Butylaniline;4-SEC-BUTYLANILINE;4-(2-BUTYL)ANILINE;AKOS BBS-00003701;4-(1-methylpropyl)-benzenamin;4-(1-methylpropyl)-Benzenamine;4-Amino-sec-butylbenzene
    3. CAS NO:30273-11-1
    4. Molecular Formula: C10H15N
    5. Molecular Weight: 149.23
    6. EINECS: 250-108-9
    7. Product Categories: N/A
    8. Mol File: 30273-11-1.mol
    9. Article Data: 3
  • Chemical Properties

    1. Melting Point: 1.08°C (estimate)
    2. Boiling Point: 244-245 °C727 mm Hg(lit.)
    3. Flash Point: 226 °F
    4. Appearance: /
    5. Density: 0.977 g/mL at 25 °C(lit.)
    6. Vapor Pressure: 0.0308mmHg at 25°C
    7. Refractive Index: n20/D 1.537(lit.)
    8. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    9. Solubility: N/A
    10. PKA: 5.02±0.10(Predicted)
    11. CAS DataBase Reference: 4-SEC-BUTYLANILINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-SEC-BUTYLANILINE(30273-11-1)
    13. EPA Substance Registry System: 4-SEC-BUTYLANILINE(30273-11-1)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. RIDADR: 2810
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: IRRITANT
    8. PackingGroup: III
    9. Hazardous Substances Data: 30273-11-1(Hazardous Substances Data)

30273-11-1 Usage

Uses

Used in Pharmaceutical Industry:
4-SEC-BUTYLANILINE is used as a reagent in the preparation of [dimethyl(dioxo)purinyl]alkanecarboxamides. These compounds serve as multifunctional TRPA1 antagonists and PDE4/7 inhibitors, which have potential therapeutic applications in the treatment of various types of pain. By targeting these specific receptors and enzymes, 4-SEC-BUTYLANILINE plays a crucial role in the development of novel pain management medications.

Check Digit Verification of cas no

The CAS Registry Mumber 30273-11-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,7 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 30273-11:
(7*3)+(6*0)+(5*2)+(4*7)+(3*3)+(2*1)+(1*1)=71
71 % 10 = 1
So 30273-11-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N/c1-3-8(2)9-4-6-10(11)7-5-9/h4-8H,3,11H2,1-2H3

30273-11-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-butan-2-ylaniline

1.2 Other means of identification

Product number -
Other names (4-sec-butylphenyl)amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:30273-11-1 SDS

30273-11-1Relevant articles and documents

Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides

Joshi-Pangu, Amruta,Ganesh, Madhu,Biscoe, Mark R.

supporting information; experimental part, p. 1218 - 1221 (2011/04/27)

A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.(Figure Presented)

Synthesis and evaluation of 4-alkylanilines as mammary tumor inhibiting aromatase inhibitors

Hartmann,Batzl

, p. 537 - 544 (2007/10/02)

The 4-alkylanilines 1-20 were synthesized to elucidate the importance of the glutarimide moiety for the aromatase inhibiting activity of aminoglutethimide [3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione, AG], the only non-steroidal aromatase inhibitor which is commercially available at present. The most interesting compounds were the (4-aminophenyl)cycloalkanes 4-6 (4, c-pentyl; 5, c-hexyl; 6, c-heptyl) and the 1-alkyl-1-(4-aminophenyl)cyclohexanes 1-3 (1, CH3; 2, C2H5; 3, n-C3H7). Derivatives 1-6 are stronger inhibitors of human placental aromatase than AG exhibiting relative potencies from 1.5 to 2.7 (AG≡1). For selectivity of action, the inhibition of desmolase (cholesterol side chain cleavage enzyme) was determined. Compounds 1-3 showed an inhibition comparable to AG, whereas compounds 4-6 exhibited no effect on desmolase. Being more potent and selective aromatase inhibitors in vitro, compounds 4-6, however, were not superior to AG in vivo, when the reduction of plasma estradiol concentration and the tumor inhibiting activity (PMSG-primed SD rats and DMBA-induced mammary carcinoma of the SD rat, postmenopausal model) were concerned.

9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines

-

, (2008/06/13)

A series of 9-(substituted amino)imidazo[4,5-f]quinolines are effective anthelmintic agents; particularly in respect to the tapeworm Hymenolepis nana.

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