2948-47-2

Basic information

• Product Name: 4-(2-hydroxypropan-2-yl)phenol
• Synonyms: 4-(2-hydroxypropan-2-yl)phenol
• CAS NO: 2948-47-2
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19038
• Mol File: 2948-47-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 174.1-174.8 °C
• Boiling Point: 150 °C(Press: 5 Torr)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• PKA: 10.01±0.26(Predicted)
• CAS DataBase Reference: 4-(2-hydroxypropan-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxypropan-2-yl)phenol(2948-47-2)
• EPA Substance Registry System: 4-(2-hydroxypropan-2-yl)phenol(2948-47-2)

Safety Data

• Hazardous Substances Data: 2948-47-2(Hazardous Substances Data)

Usage

Uses

Used in Cosmetics and Personal Care Products:
4-(2-hydroxypropan-2-yl)phenol is used as a solvent and fragrance ingredient in cosmetics and personal care products. Its ability to dissolve a variety of substances makes it suitable for creating stable formulations that can incorporate different active ingredients.
Used in Household Cleaners:
In the household cleaning industry, 4-(2-hydroxypropan-2-yl)phenol is used as a solvent to help dissolve dirt, grease, and stains. Its effectiveness in breaking down these substances contributes to the cleaning power of various household products.
Used in Pharmaceuticals:
4-(2-hydroxypropan-2-yl)phenol is used as a stabilizer and carrier for active ingredients in pharmaceuticals. Its role in ensuring the stability and delivery of these ingredients is crucial for the efficacy and safety of medications.
Used in Topical Medications:
As a component of topical medications, 4-(2-hydroxypropan-2-yl)phenol aids in the absorption and distribution of active pharmaceutical agents on the skin. This enhances the effectiveness of treatments for various skin conditions.
Used in Ink, Dye, and Paint Manufacturing:
4-(2-hydroxypropan-2-yl)phenol is utilized in the production of inks, dyes, and paints due to its solubility and compatibility with pigments and other components. Its presence contributes to the quality and performance of these products.

Upstream product

• 124-38-9 carbon dioxide 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 94571-13-8 1-methyl-1-<4-(benzyloxy)phenyl>ethanol 
• 6793-92-6 p-benzyloxyphenylbromide 
• 4286-23-1 4-isopropenylphenol 
• 149683-53-4 4-(tert-butyldimethylsilyloxy)acetophenone 
• 129181-43-7 1-[{(1,1-dimethylethyl)dimethylsilyl}oxy]-4-(prop-1-en-2-yl)benzene 
• 99-89-8 4-Isopropylphenol 
• 80-05-7 BPA 
• 13031-43-1 4-acetyloxyacetophenone 
• 676-58-4 methylmagnesium chloride 
• 75-16-1 methylmagnesium bromide 
• 99-93-4 4-Hydroxyacetophenone 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 14151-63-4 2-(4-hydroxy-3-methylphenyl)-2-(4'-hydroxyphenyl)propane 
• 80-05-7 BPA 
• 63721-00-6 Diethyl-p-phosphoryloxycumylchlorid 
• 63721-02-8 p-Acetoxycumylchlorid 
• 55182-48-4 4-Isopropyliden-2,5-cyclohexadienon 
• 35029-26-6 4-(p-hydroxyphenyl)-4-methyl-1-pentene 
• 59147-09-0 Diethyl-p-isopropenylphenyl-phosphat 
• 2759-56-0 p-isopropenyl-phenol acetate 

Relevant articles and documents

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Method for selectively oxidizing cumene compounds

The invention relates to a method for selectively oxidizing cumene compounds, and the method comprises the following steps: placing cumene compounds shown in a formula (I), an iron porphyrin catalyst,an oxidant and a dispersant into a ball milling tank, sealing the ball milling tank, performing ball milling for 3 to 24 hours at a rotating speed of 100 to 800 rpm at room temperature, stopping ballmilling once every 1 to 3 hours in the ball milling process, discharging gases in the ball milling tank, finishing the reaction, and performing post-treatment on a reaction mixture to obtain product2-phenyl-2-propanol compound shown in a formula (II); according to the invention, the oxidation conversion of the cumene and derivatives thereof is realized through solid-phase ball milling, the reaction mode is novel, the operation is convenient, and the energy consumption is low; the method needs no organic solvent, thus effectively avoiding the use of toxic and harmful organic solvents and being green and environment-friendly; has low peroxide content and high safety factor, and high 2-phenyl-2-propanol and derivative selectivity and meets the social requirements of the current green chemical process, environmental compatibility chemical process and biological compatibility chemical process.

Multienzyme One-Pot Cascade for the Stereoselective Hydroxyethyl Functionalization of Substituted Phenols

The operability and substrate scope of a redesigned vinylphenol hydratase as a single biocatalyst or as part of multienzyme cascades using either substituted coumaric acids or phenols as stable, cheap, and readily available substrates are reported.

Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system

Selective oxidation of aliphatic C-H bonds in alkylphenols serves significant roles not only in generation of functionalized intermediates that can be used to synthesize diverse downstream chemical products, but also in biological degradation of these environmentally hazardous compounds. Chemo-, regio-, and stereoselectivity; controllability; and environmental impact represent the major challenges for chemical oxidation of alkylphenols. Here, we report the development of a unique chemomimetic biocatalytic system originated from the Gram-positive bacterium Corynebacterium glutamicum. The system consisting of CreHI (for installation of a phosphate directing/ anchoring group), CreJEF/CreG/CreC (for oxidation of alkylphenols), and CreD (for directing/anchoring group offloading) is able to selectively oxidize the aliphatic C-H bonds of p-And m-Alkylated phenols in a controllable manner. Moreover, the crystal structures of the central P450 biocatalyst CreJ in complex with two representative substrates provide significant structural insights into its substrate flexibility and reaction selectivity.

Photocatalytic activity of one-dimensional Ag2V4O11 nanowires in the degradation of bisphenol a under visible-light irradiation

In this study, one-dimensional Ag2V4O11 nanowires were prepared by a facile hydrothermal process and developed as a novel visible-light-sensitive photocatalyst. Ag2V4O11 nanowires were single-crystalline with large specific surface area and good visible-light absorption performance. The degradation of bisphenol A (BPA) by Ag2V4O11 was systematically investigated under visible-light irradiation, and the influence parameters were studied. Experimental results indicated that Ag2V4O11 nanowires had excellent photocatalytic activities and the degradation efficiency of BPA could reach 100 % within 150 min with 1 mg/mL Ag2V4O11. Intermediates of the degradation reaction were detected by high performance liquid chromatography coupled with mass spectrometry, and a possible degradation pathway was proposed. In addition, after eight cycles for the photodegradation of BPA, Ag2V4O11 did not exhibit significant loss of photocatalytic activity, confirming its stability and long-time reusability. The photocatalytic mechanism was studied by active species trapping experiments, revealing that the holes (h+) and hydroxyl radicals (·OH) played key roles in RhB degradation. This study provides a potential effective Ag2V4O11 nanowire photocatalyst for water purification and other applications.

CHEMICAL COMPOUNDS

The present invention relates to new sulfonamide URAT-1 inhibitor compounds of formula (I) or a pharmaceutically acceptable salt thereof: to compositions containing them, to processes for their preparation and to intermediates used in such processes, and

Structure-activity relationships of bisphenol a analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist

Our multi-template approach for drug discovery, focusing on protein targets with similar fold structures, has yielded lead compounds for various targets. We have also shown that a diphenylmethane skeleton can serve as a surrogate for a steroid skeleton. H

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, inflammatory disease of the joints, neuropathies, HIV-related neuropathy, nerve injury, neurodegeneration, stroke, urinary bladder hypersensitivity including urinary incontinence, cystitis, stomach duodenal ulcer, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), fecal urgency, gastro-esophageal reflux disease (GERD), Crohn's disease, asthma, chronic obstructive pulmonary disease, cough, neurotic/allergic/inflammatory skin disease, psoriasis, pruritus, prurigo, irritation of skin, eye or mucous membrane, hyperacusis, tinnitus, vestibular hypersensitivity, episodic vertigo, cardiac diseases such as myocardial ischemia, hair growth-related disorders such as effluvium, alopecia, rhinitis, and pancreatitis.

Method for preparing bisphenol A

A method for preparing bisphenol A is disclosed, with a selectivity for the p,p'-isomer of greater than about 97%. The method involves reacting phenol with p-isopropenylphenol or 2-(4-hydroxyphenyl)-2-propanol in the presence of a catalyst, at a reaction temperature of no greater than about 65° C. The bisphenol A product is preferably purified by a technique which omits the use of adduct crystallization.

Linear Free Energy Relationship Studies of the Dimethyldioxirane C-H Bond Insertion Reaction

The relative rates of reaction of a series of p-substituted cumenes with dimethyldioxirane have been studied.The products are the corresponding cumyl alcohols.Treatment of the rate data with the Hammett substituent constants reveals that the insertion reaction is an electrophilic process with ρ = -2.76.Similar tretment of the data with the Brown-Okamoto substituent constants gives ρ+ = -1.61.The second-order rate constants for the reaction of a series of substituted adamantanes with dimethyldioxirane were also determined.Again, the products are the corresponding adamantanols.The rate constants were correlated with several types of substituent constants.The best correlations were obtained with the Taft ?* and ?I constants which gave ρ* = -1.08 and ρI = -2.39, respectively.Thus, the insertion reaction in this aliphatic system is also electrophilic.