28525-13-5

Basic information

• Product Name: 4-(phenylsulfonyl)benzonitrile
• Synonyms: 4-(phenylsulfonyl)benzonitrile
• CAS NO: 28525-13-5
• Molecular Formula: C₁₃H₉NO₂S
• Molecular Weight: 243.28106
• Mol File: 28525-13-5.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(phenylsulfonyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(phenylsulfonyl)benzonitrile(28525-13-5)
• EPA Substance Registry System: 4-(phenylsulfonyl)benzonitrile(28525-13-5)

Safety Data

• Hazardous Substances Data: 28525-13-5(Hazardous Substances Data)

Usage

Description

4-(phenylsulfonyl)benzonitrile is a chemical compound that features a benzene ring with a nitrile group and a sulfone group attached to it. It is recognized for its potential pharmacological activities, such as anti-inflammatory and analgesic properties, and is valued in the field of medicinal chemistry for its role in treating certain diseases and conditions.

Uses

Used in Pharmaceutical Industry:
4-(phenylsulfonyl)benzonitrile is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and potential pharmacological activities.
Used in Agrochemical Industry:
4-(phenylsulfonyl)benzonitrile is utilized as a precursor in the development of agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Dye and Pigment Industry:
4-(phenylsulfonyl)benzonitrile is employed as a component in the production of dyes and pigments, taking advantage of its chemical properties to enhance color characteristics.
Used in Material Science:
It serves as a key intermediate in the synthesis of functional materials, where its unique structure contributes to the development of advanced materials with specific properties.
Used in Medicinal Chemistry Research:
4-(phenylsulfonyl)benzonitrile is used as a research compound for exploring its potential role in treating certain diseases and conditions, highlighting its importance in the advancement of medical treatments.

Upstream product

• 10442-39-4 tetra-n-butylammonium cyanide 
• 111278-48-9 C₁₈H₁₄N₂O₂S₂ 
• 141212-52-4 (phenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole 
• 66-39-7 4-(phenylsulfonyl)benzaldehyde 
• 98-80-6 phenylboronic acid 
• 3058-39-7 4-iodobenzonitrile 
• 780-69-8 triethoxyphenylsilane 
• 17672-27-4 4-hydrazinobenzonitrile 
• 873-55-2 sodium benzenesulfonate 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 623-03-0 4-Cyanochlorobenzene 
• 2252-32-6 4-cyanophenyldiazonium tetrafluoroborate 

Downstream Products

• 65085-83-8 4'-(phenylsulfonyl)acetophenone 
• 4779-37-7 2-bromo-1-(4-(phenylsulfonyl)phenyl)ethan-1-one 
• 78064-96-7 4-(pyrrolidin-1-ylmethyl)benzonitrile 
• 1440419-03-3 tert-butyl 2-(4-cyanophenyl)pyrrolidine-1-carboxylate 
• 1588517-27-4 tert-butyl 2-(4-(phenylsulfonyl)phenyl)pyrrolidine-1-carboxylate 
• 1520089-89-7 tert-butyldimethyl(phenyl(4-(phenylsulfonyl)phenyl)methoxy)silane 
• 1454285-13-2 5-amino-N-[[4-(benzenesulfonyl)phenyl]methyl]furo[2,3-c]pyridine-2-carboxamide 
• 1454285-49-4 N-[[4-(benzenesulfonyl)phenyl]methyl]-5-[(diphenylmethylidene)amino]furo[2.3-c]pyridine-2-carboxamide 
• 1454285-48-3 N-[[4-(benzenesulfonyl)phenyl]methyl]-5-chlorofuro[2,3-c]pyridine-2-carboxamide 
• 1454285-18-7 4-amino-N-[[4-(benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3.4-c]pyridine-2-carboxamide 
• 1454285-00-7 7-amino-N-[[4-(benzenesulfonyl)phenyl]methyl]furo[2.3-c]pyridine-2-carboxamide 
• 1454284-71-9 imidazo[1,5-a]pyridine-7-carboxylic acid 4-benzenesulfonylbenzylamide 
• 1454284-63-9 pyrazolo[1,5-a]pyrimidine-5-carboxylic acid 4-benzenesulfonylbenzylamide 
• 1454284-48-0 imidazo[1,2-b]pyridazine-6-carboxylic acid 4-benzenesulfonyl-benzylamide 

Relevant articles and documents

Visible-Light-Mediated Late-Stage Sulfonylation of Boronic Acids via N-S Bond Activation of Sulfonamides

A visible-light-mediated late-stage arylation of N-S bonds in sulfonamides has been developed with using readily available imines as sulfonyl radical source. Diverse complex sulfones could be synthesized by prefunctionalizaiton and subsequent N-S bond ary

Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

The present invention relates to a method for manufacturing a sulfone and sulfonyl derivative compound using sodium (tert-butyldimethylsilyl)oxymethanesulfinate, which is a novel organic sulfin salt, wherein the novel organic sulfin salt has good stability, environmental friendliness and economy, and is easy to handle, and thus significantly reduces the amount of transition metal catalysts and the amount of organic sulfin salts used when introducing aryl or alkenyl. Also, alkylation, arylation, amination, and fluorination are all possible during secondary functionalization. Therefore, the present invention can be usefully used in preparation and mass production of various kinds of sulfones and derivatives thereof including asymmetric sulfone derivatives.

Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis

An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates is reported. In our protocol, a single ligand CuI photocatalyst formed in situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrates a promising approach toward the synthesis of diverse and useful organosulfones.