28153-22-2 Usage
Description
[1-(4-nitrophenyl)ethylidene]hydrazine, a chemical compound with the molecular formula C8H9N3O2, is a hydrazine derivative characterized by a nitrogen-nitrogen double bond. [1-(4-nitrophenyl)ethylidene]hydrazine is known for its yellow color, which is attributed to the presence of the 4-nitrophenyl group. It is also recognized for its moderate toxicity, necessitating careful handling and storage to prevent skin and eye irritation.
Uses
Used in Chemical Synthesis:
[1-(4-nitrophenyl)ethylidene]hydrazine is utilized as a reagent in the synthesis of various organic compounds. Its unique structure and properties make it a valuable component in the creation of a wide range of chemical products.
Used as a Chemistry Experiment Indicator:
The yellow 4-nitrophenyl group in [1-(4-nitrophenyl)ethylidene]hydrazine serves as an indicator in chemistry experiments. Its color change can be used to monitor reactions and provide visual cues for students and researchers, enhancing the educational and experimental process.
Used in Pharmaceutical Research:
Given its chemical properties and reactivity, [1-(4-nitrophenyl)ethylidene]hydrazine may also hold potential in the field of pharmaceutical research. Its ability to form various organic compounds could contribute to the development of new drugs and therapies, although further investigation is required to explore these possibilities.
Used in Analytical Chemistry:
[1-(4-nitrophenyl)ethylidene]hydrazine's distinct characteristics make it suitable for use in analytical chemistry, where it can be employed to detect and measure the presence of specific substances. Its role as an indicator can be particularly useful in colorimetric assays and other analytical techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 28153-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,5 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 28153-22:
(7*2)+(6*8)+(5*1)+(4*5)+(3*3)+(2*2)+(1*2)=102
102 % 10 = 2
So 28153-22-2 is a valid CAS Registry Number.
28153-22-2Relevant articles and documents
Synthesis and Anticholinesterase Activity Evaluation of Asymmetric Azines
Figueredo, Andreza S.,Queiroz, Jaqueline E.,Dias, Lucas D.,Vidal, Hérika D. A.,Machado, Ingrid V.,Vila Verde, Giuliana M.,Aquino, Gilberto L. B.
, p. 544 - 549 (2019/11/20)
Azines or di-imines are compounds containing R1R2C=N-N=CR3R4 fragment in its structure. These compounds have received special attention due to their importance as intermediates in the synthesis of drugs and substances with diverse pharmacological activities. In this research, twelve compounds derived of asymmetric azines of aryl aldehydes and aryl ketones were synthesized by microwave assisted irradiation, and their ability to inhibit acetylcholinesterase (AChE) enzyme was tested using the Ellman method. Among the evaluated azines, five compounds were able to inhibit AChE, especially compounds (7E, 8E)-1-benzylidene-2-(1-(4-nitrophenyl)ethylidene)hydrazine (7) and (7E,8E)-2-(1-(4-nitrophenyl)ethylidene)-1-((pyridin-2-yl)methylene)hydrazine (14), which showed percentage inhibition of 18.34% and 17.43% at concentrations of 22.46 and 10 μM, respectively.
A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β
Zhao, Li-Ming,Jin, Hai-Shan,Liu, Jinzhong,Skaar, Todd C.,Ipe, Joseph,Lv, Wei,Flockhart, David A.,Cushman, Mark
, p. 5400 - 5409 (2016/10/24)
The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) deriva
A convenient method for the preparation of N-unsubstituted hydrazones of aromatic ketones and aldehydes
Shirinian,Belen'kii,Krayushkin
, p. 2171 - 2172 (2007/10/03)
A general and useful method for the synthesis of N-unsubstituted hydrazones of aromatic ketones and aldehydes in good yields was elaborated. The use of a large excess of hydrazine hydrate and catalytic amounts of p-toluenesulfonic acid makes it possible to prepare the hydrazones without an admixture of the corresponding azine.
