280762-79-0Relevant articles and documents
HIV INTEGRASE INHIBITORS FROM PYRIDOXINE
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Page/Page column 59, (2009/12/28)
The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HΙV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.
Versatile synthesis of (+)-deoxypyridinoline, a biochemical marker for diagnosis of osteoporosis
Adamczyk, Maciej,Rao Akireddy, Srinivasa,Reddy, Rajarathnam E.
, p. 3107 - 3110 (2007/10/03)
A versatile chiral synthesis of the bone collagen cross-link, (+)-deoxypyridinoline (Dpd, 1) was described starting from a 3-hydroxypyridine derivative (2) via sequential introduction of three amino acid chains followed by hydrolysis. The key synthon 2, was prepared from vitamin B6 (6).