243139-71-1

Basic information

• Product Name: 2,4,5-TRIFLUOROBENZYL CHLORIDE
• Synonyms: 2,4,5-TRIFLUOROBENZYL CHLORIDE;2,4,5-TRIFLUOROBENZYL CHORIDE;Benzene, 1-(chloromethyl)-2,4,5-trifluoro- (9CI);1-(Chloromethyl)-2,4,5-trifluorobenzene, alpha-Chloro-2,4,5-trifluorotoluene
• CAS NO: 243139-71-1
• Molecular Formula: C₇H₄ClF₃
• Molecular Weight: 180.55
• Product Categories: HALOMETYL;Miscellaneous;Fluorine series
• Mol File: 243139-71-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 175℃
• Flash Point: 65°C
• Appearance: /
• Density: 1,689 g/cm3
• Vapor Pressure: 0.091mmHg at 25°C
• Refractive Index: 1.5050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4,5-TRIFLUOROBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIFLUOROBENZYL CHLORIDE(243139-71-1)
• EPA Substance Registry System: 2,4,5-TRIFLUOROBENZYL CHLORIDE(243139-71-1)

Safety Data

• Hazard Codes: C,Xn
• Statements: 34-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 243139-71-1(Hazardous Substances Data)

Usage

Uses

2,4,5-Trifluorobenzyl chloride is a useful research chemical.

InChI:InChI=1/C8H6F4O2/c1-14-8-6(11)4(9)3(2-13)5(10)7(8)12/h13H,2H2,1H3

Upstream product

• 875664-57-6 4,5-difluoro-2-methylaniline 
• 127371-50-0 1,2-difluoro-4-methyl-5-nitrobenzene 
• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 887267-34-7 2,4,5-Trifluoro-toluene 
• 50-00-0 formaldehyd 
• 367-23-7 1,2,4-trifluorobenzene 

Downstream Products

• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 220141-74-2 2-(2,4,5-trifluorophenyl)acetonitrile 
• 1256768-67-8 [2-(2,4,5-trifluorobenzyl)-7-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid 
• 1256768-49-6 [2-(2,4,5-trifluorobenzyl)-7-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester 
• 1256768-63-4 [2-(2,4,5-trifluorobenzyl)-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid 
• 1256768-46-3 [2-(2,4,5-trifluorobenzyl)-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester 
• 1159577-46-4 C₂₃H₂₅F₃N₂O 
• 1000987-31-4 C₁₃H₈F₃NO₃ 

Relevant articles and documents

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.

Industrial preparation method of 2,4,5-trifluorophenylacetic acid

The invention relates to the technical field of preparation of chemical drug intermediates, and particularly discloses an industrial preparation method of 2,4,5-trifluorophenylacetic acid. The preparation method comprises the following steps: carrying out a nitration reaction, a fluorination reaction, a hydrogenation reduction reaction, a diazotization reaction, a halogenation reaction, a cyaniding reaction, a thermal decomposition reaction and a hydrolysis reaction on 2,4-dichlorotoluene to prepare the 2,4,5-trifluorophenylacetic acid. The method has the advantages of low preparation cost andhigh product yield.