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  • 220957-39-1 Structure
  • Basic information

    1. Product Name: 5-Bromofuro[2,3-b]pyridine
    2. Synonyms: 5-Bromofuro[2,3-b]pyridine;5-broMofuro[2
    3. CAS NO:220957-39-1
    4. Molecular Formula: C7H4BrNO
    5. Molecular Weight: 198
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 220957-39-1.mol
    9. Article Data: 4
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 226℃
    3. Flash Point: 91℃
    4. Appearance: /
    5. Density: 1.710
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Bromofuro[2,3-b]pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Bromofuro[2,3-b]pyridine(220957-39-1)
    11. EPA Substance Registry System: 5-Bromofuro[2,3-b]pyridine(220957-39-1)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220957-39-1(Hazardous Substances Data)

220957-39-1 Usage

Description

5-Bromofuro[2,3-b]pyridine is a heterocyclic chemical compound characterized by the molecular formula C6H4BrNO. It features a unique structure with a furan ring fused to a pyridine ring, and a bromine atom attached at the 5-position of the furan ring. 5-Bromofuro[2,3-b]pyridine is widely recognized for its versatility in medicinal chemistry and organic synthesis, serving as a valuable building block for the creation of diverse pharmaceuticals and organic compounds.

Uses

Used in Medicinal Chemistry:
5-Bromofuro[2,3-b]pyridine is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of biologically active molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the realm of organic synthesis, 5-Bromofuro[2,3-b]pyridine is employed as a versatile building block for the preparation of a wide range of organic compounds. Its ability to form carbon-carbon and carbon-heteroatom bonds makes it an essential component in the synthesis of complex organic molecules.
Used as a Reagent in Chemical Reactions:
5-Bromofuro[2,3-b]pyridine also serves as a reagent in various chemical reactions, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. Its presence facilitates the synthesis of new compounds with desired properties and functions.
Used in the Synthesis of Biologically Active Molecules:
Due to its structural features, 5-Bromofuro[2,3-b]pyridine is extensively used in the synthesis of biologically active molecules. These molecules have potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in the Development of Materials:
5-Bromofuro[2,3-b]pyridine contributes to the development of novel materials with specific properties, such as conductivity, magnetism, or optical activity. Its integration into material science allows for the creation of advanced materials with potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 220957-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,9,5 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 220957-39:
(8*2)+(7*2)+(6*0)+(5*9)+(4*5)+(3*7)+(2*3)+(1*9)=131
131 % 10 = 1
So 220957-39-1 is a valid CAS Registry Number.

220957-39-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Aldrich

  • (ADE001191)  5-Bromofuro[2,3-b]pyridine  AldrichCPR

  • 220957-39-1

  • ADE001191-1G

  • 7,411.95CNY

  • Detail

220957-39-1Synthetic route

5-bromo-3-((trimethylsilyl)ethynyl)pyridin-2-oI
942589-70-0

5-bromo-3-((trimethylsilyl)ethynyl)pyridin-2-oI

5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

Conditions
ConditionsYield
With copper(l) iodide; triethylamine In ethanol at 70℃; for 3h;32%
5-bromo-3-ethynyl-2(1H)-pyridinone
942589-71-1

5-bromo-3-ethynyl-2(1H)-pyridinone

5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 0.5h; Irradiation;
5-nitrofuro<2,3-b>pyridine
34668-29-6

5-nitrofuro<2,3-b>pyridine

5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Al(Hg), water / diethyl ether / 3 h / Ambient temperature
2: 1.) 47 percent aq. HBr, NaNO2, 2.) CuBr, 37 percent aq. HBr / 1.) 0 deg C, 15 min
View Scheme
furo[2,3-b]pyridin-5-ylamine
34668-30-9

furo[2,3-b]pyridin-5-ylamine

5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

Conditions
ConditionsYield
With hydrogen bromide; copper(I) bromide; sodium nitrite 1.) 0 deg C, 15 min; Yield given; Multistep reaction;
5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

C7H4FNO3S

C7H4FNO3S

Conditions
ConditionsYield
Stage #1: 5-bromofuro<2,3-b>pyridine With bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); N-Methyldicyclohexylamine; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate In isopropyl alcohol at 110℃; for 1h; Microwave irradiation;
Stage #2: With N-fluorobis(benzenesulfon)imide In isopropyl alcohol at 20℃; for 3h;
42%
methyl 3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-thiophenecarboxylate
942589-73-3

methyl 3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-thiophenecarboxylate

5-bromofuro<2,3-b>pyridine
220957-39-1

5-bromofuro<2,3-b>pyridine

methyl 5-(4-furo[2,3-b]pyridin-5-ylphenyl)-3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate
942589-74-4

methyl 5-(4-furo[2,3-b]pyridin-5-ylphenyl)-3-[[(4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 100℃; for 0.3h; Irradiation;

220957-39-1Relevant articles and documents

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

-

, (2021/10/11)

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS

-

Page/Page column 49, (2008/06/13)

Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.

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