2165-04-0Relevant articles and documents
Copper-catalyzed aerobic dehydrogenation of C-C to C=C bonds in the synthesis of pyridazinones
Liang, Lei,Yang, Guanyu,Xu, Fengrong,Niu, Yan,Sun, Qi,Xu, Ping
supporting information, p. 6130 - 6136 (2013/09/24)
A simple and efficient procedure for the synthesis of pyridazin-3(2H)-ones through copper-catalyzed dehydrogenation of a single C-C bond of 4,5-dihydropyridazin-3(2H)-ones to a C=C bond with oxygen as the terminal oxidant is described. Functional groups including hydroxy, carboxylic, bromo, chloro, cyano, nitro and alkoxy were all tolerated under the reaction conditions. Moreover, this methodology was applied to the preparation of a series of structurally similar N-substituted 6-phenylpyridazinone compounds containing fluorine. The dehydrogenation reactions exhibit good yields and selectivity. Copper-catalyzed dehydrogenation of a C-C bond of 4,5-dihydropyridazinones to a C=C bond with oxygen as the terminal oxidant is described. Various functional groups were tolerated under the reaction conditions. The method was also applied to the preparation of a series of N-substituted 6-phenylpyridazinones containing fluoride. The dehydrogenation reactions exhibit good yields and selectivity.
ALKYLATION OF 6-OXO-1,6-DIHYDROPYRIDAZINES BY TRIETHYLOXONIUM FLUOROBORATE
Volynets, N. F.,Smartseva, I. V.,Khramova, I. V.,Pavlova, L. A.
, p. 1604 - 1608 (2007/10/02)
Irrespective of the nature of the substituents at positions 1 and 3 the heterocycle, 6-oxo-1-phenyl(methyl)-3-aryl-1,6-dihydropyridazines are alkylated by the action of triethyloxonium fluoroborate at the oxygen atom of the carbonyl group, forming heteroaromatic 1-ethoxypyridazinium salts.
ALKYLATION OF 1,3-DISUBSTITUTED 60OXODIHYDROPYRIDAZINES
Volynets, N. F.,Samartseva, I. V.,Pavlova, L. A.
, p. 1365 - 1366 (2007/10/02)
-