19922-82-8 Usage
Description
2-Bromo-1-(4-nitrophenyl)ethanol, also known as 4-Bromo-2-hydroxy-1-nitrophenylethane, is a chemical compound characterized by the molecular formula C8H8BrNO3. It presents as a white to off-white crystalline powder, widely recognized for its applications in organic synthesis and pharmaceutical research. 2-bromo-1-(4-nitrophenyl)ethanol is endowed with antimicrobial and antifungal properties, which render it a beneficial component in the formulation of pharmaceuticals and personal care products. Moreover, 2-Bromo-1-(4-nitrophenyl)ethanol has demonstrated its potential as a corrosion inhibitor in metal surface treatments, although it requires careful handling due to its harmful effects if ingested, inhaled, or contacted with the skin.
Uses
Used in Pharmaceutical Industry:
2-Bromo-1-(4-nitrophenyl)ethanol is used as an active pharmaceutical ingredient for its antimicrobial and antifungal properties, contributing to the development of treatments for various infections and conditions caused by microbial and fungal pathogens.
Used in Personal Care Products:
In the personal care industry, 2-Bromo-1-(4-nitrophenyl)ethanol is used as a preservative to prevent microbial and fungal contamination, ensuring the safety and efficacy of products such as cosmetics, creams, and lotions.
Used in Metal Surface Treatments:
2-Bromo-1-(4-nitrophenyl)ethanol is utilized as a corrosion inhibitor in metal surface treatments, providing protection against corrosion and extending the lifespan of metal components and structures.
Used in Organic Synthesis:
As a key intermediate in organic synthesis, 2-Bromo-1-(4-nitrophenyl)ethanol is employed in the production of various organic compounds and pharmaceuticals, facilitating the synthesis of complex molecules and contributing to the advancement of chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 19922-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,2 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19922-82:
(7*1)+(6*9)+(5*9)+(4*2)+(3*2)+(2*8)+(1*2)=138
138 % 10 = 8
So 19922-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4,8,11H,5H2
19922-82-8Relevant articles and documents
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Williams et al.
, p. 993,994-996 (1975)
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Tandem transfer hydrogenation-epoxidation of ketone substrates catalysed by alkene-tethered Ru(ii)-NHC complexes
Malan, Frederick P.,Singleton, Eric,Van Rooyen, Petrus H.,Landman, Marilé
supporting information, p. 8472 - 8481 (2019/06/14)
A series of nine cyclopentadienyl Ru(ii)-NHC complexes (1-9) have been synthesised by systematically varying the ligand and/or ligand substituents: η5-C5H4R′ (R′ = H, Me), EPh3 (E = P, As), NHC (Im, BIm), where NHC = Im(R)(R′) (R, R′ = Me, Bn, 4-NO2Bn, C2H4Ph, C4H7). Each of the Ru(ii)-NHC complexes features an N-alkenyl tether to attain bidentate NHC ligands. All complexes found application as catalysts in the tandem transfer hydrogenation and epoxidation reactions of carbonyl substrates. The catalytic activity of the complexes was shown to be similar, with efficiencies of up to 69% conversion after 18 hours and varying alcohol:epoxide selectivity for a variety of electronically diverse carbonyl substrates. Complex 3, with a nitro-containing substituent on the NHC ligand, was the only complex that showed preference for the alcohol product over the epoxide after 18 hours of reaction time.
Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH
Mikleu?evi?, Ana,Primo?i?, Ines,Hrenar, Tomica,Salopek-Sondi, Branka,Tang, Lixia,Elenkov, Maja Majeri?
, p. 930 - 935 (2016/09/13)
Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.
