194035-01-3

Basic information

• Product Name: 1H-Pyrrole-2,4-dicarboxylic acid, 2,5-dihydro-1-(9-phenyl-9H-fluoren-9-yl)-, 2-ethyl 4-methyl ester, (S)-
• CAS NO: 194035-01-3
• Molecular Formula: C28H25NO4
• Molecular Weight: 439.511
• Mol File: 194035-01-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,4-dicarboxylic acid, 2,5-dihydro-1-(9-phenyl-9H-fluoren-9-yl)-, 2-ethyl 4-methyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,4-dicarboxylic acid, 2,5-dihydro-1-(9-phenyl-9H-fluoren-9-yl)-, 2-ethyl 4-methyl ester, (S)-(194035-01-3)
• EPA Substance Registry System: 1H-Pyrrole-2,4-dicarboxylic acid, 2,5-dihydro-1-(9-phenyl-9H-fluoren-9-yl)-, 2-ethyl 4-methyl ester, (S)-(194035-01-3)

Safety Data

• Hazardous Substances Data: 194035-01-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 194034-94-1 (S)-4-Oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 194034-91-8 (2S,4R)-4-Hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

A simple route to 4-substituted-3,4-didehydroprolines, mechanistic probes for the inhibition of prolyl-4-hydroxylase

Treatment of the 9-phenylfluoren-9-yl (Pf) protected 4-oxo-proline-ethyl ester (6) with NaHMDS and N-(5-chloro-2-pyridyl)triflimide gives the corresponding enoltriflate in good yield. Pd mediated coupling of the triflate with trimethylalkyltin, trimethylaryltin, trimethylalkenyltin and carbon monoxide proceeds to give the 4-substituted-3,4-didehydroprolines.