194034-91-8

Basic information

• Product Name: L-Proline, 4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-, ethyl ester, (4R)-
• CAS NO: 194034-91-8
• Molecular Formula: C26H25NO3
• Molecular Weight: 399.489
• Mol File: 194034-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Proline, 4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-, ethyl ester, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-, ethyl ester, (4R)-(194034-91-8)
• EPA Substance Registry System: L-Proline, 4-hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-, ethyl ester, (4R)-(194034-91-8)

Safety Data

• Hazardous Substances Data: 194034-91-8(Hazardous Substances Data)

Upstream product

• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 

Downstream Products

• 194035-01-3 (S)-1-(9-Phenyl-9H-fluoren-9-yl)-2,5-dihydro-1H-pyrrole-2,4-dicarboxylic acid 2-ethyl ester 4-methyl ester 
• 194034-94-1 (S)-4-Oxo-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

A simple route to 4-substituted-3,4-didehydroprolines, mechanistic probes for the inhibition of prolyl-4-hydroxylase

Treatment of the 9-phenylfluoren-9-yl (Pf) protected 4-oxo-proline-ethyl ester (6) with NaHMDS and N-(5-chloro-2-pyridyl)triflimide gives the corresponding enoltriflate in good yield. Pd mediated coupling of the triflate with trimethylalkyltin, trimethylaryltin, trimethylalkenyltin and carbon monoxide proceeds to give the 4-substituted-3,4-didehydroprolines.