19353-92-5

Basic information

• Product Name: 4-DIMETHYLAMINOBENZHYDRAZIDE
• Synonyms: LABOTEST-BB LT00454413;4-DIMETHYLAMINO-BENZOIC ACID HYDRAZIDE;4-(DIMETHYLAMINO)BENZENE-1-CARBOHYDRAZIDE;4-DIMETHYLAMINOBENZHYDRAZIDE;4-(N,N-DIMETHYLAMINO)BENZHYDRAZIDE;AKOS BC-1518;4-Dimethylaminobenzohydrazide;Benzoic acid, 4-(dimethylamino)-, hydrazide
• CAS NO: 19353-92-5
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.22
• EINECS: 242-985-1
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 19353-92-5.mol
• Article Data: 34

Chemical Properties

• Melting Point: 174-175°C
• Appearance: /
• Density: 1.156
• Refractive Index: 1.601
• PKA: 13.12±0.10(Predicted)
• BRN: 2210856
• CAS DataBase Reference: 4-DIMETHYLAMINOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYLAMINOBENZHYDRAZIDE(19353-92-5)
• EPA Substance Registry System: 4-DIMETHYLAMINOBENZHYDRAZIDE(19353-92-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-40-22
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19353-92-5(Hazardous Substances Data)

Usage

General Description

4-Dimethylaminobenzhydrazide is a chemical compound used as a color developer in the production of dye couplers and photographic materials. It is also used in hair dyes and as a polymerization inhibitor in industrial processes. 4-DIMETHYLAMINOBENZHYDRAZIDE has been found to have low acute toxicity and is not expected to cause adverse effects on human health when used appropriately. It is important to handle 4-dimethylaminobenzhydrazide with care and in accordance with safety guidelines due to its irritant and sensitizing properties, as well as its potential to cause skin and eye irritation if not properly handled.

InChI:InChI=1/C9H13N3O/c1-12(2)8-5-3-4-7(6-8)9(13)11-10/h3-6H,10H2,1-2H3,(H,11,13)

Upstream product

• 1202-25-1 methyl 4-(N,N-dimethylamino)benzoate 
• 21176-99-8 p-Dimethylamino-thiolbenzoesaeure-methylester-methoiodid 
• 118792-43-1 S-methyl 4-(dimethylamino)benzothioate 
• 380922-13-4 N-Boc-N'-[4-(N,N-dimethylamino)benzoyl]hydrazine 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 126929-66-6 1-<α-methylthio-(p-trimethylammonia)benzylidene>piperidinium bromide 
• 10287-53-3 ethyl p-dimethyaminolbenzoate 
• 613-94-5 benzoic acid hydrazide 
• 4755-50-4 4-(dimethylamino)benzoyl chloride 
• 1644630-67-0 C₁₅H₁₃ClN₂O₄ 
• 302-01-2 hydrazine 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 101289-91-2 4-dimethylamino-benzoic acid-(4-amino-benzylidenehydrazide) 
• 51641-49-7 4-[5-(4-dimethylamino-phenyl)-[1,3,4]oxadiazol-2-yl]-naphthalene-1,8-dicarboxylic acid anhydride 
• 864083-72-7 3-[4-(dimethylamino)phenyl]-6-phenyl-1,2,4-triazine 
• 76457-90-4 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole 
• 891616-64-1 N-4-(dimethylamino)benzamido-N'-1-naphthylthiourea 
• 889223-05-6 N-4-(dimethylamino)benzamido-N'-1-naphthylurea 
• 1251851-80-5 C₁₀H₁₂N₃O₂S^(1-)*K⁽¹⁺⁾ 
• 1254254-12-0 ethyl 1-(2-(4-(dimethylamino)benzoyl)hydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate 
• 613-94-5 benzoic acid hydrazide 
• 6797-81-5 4-dimethylamino-benzoic acid N'-benzoyl-hydrazide 
• 6781-67-5 1-<4-Methoxy-benzoyl>-2-<4-dimethylamino-benzoyl>-hydrazin 
• 1447735-14-9 3-{5-[4-(dimethylamino)phenyl]-1,3,4-thiadiazol-2-yl}biphenyl-2,3’,4,5’,6-pentol 

Relevant articles and documents

A novel jointly colorimetric and fluorescent sensor for Cu2+ recognition and its complex for sensing S2? by a Cu2+ displacement approach in aqueous media

In this work, a simple and easily synthesized Schiff-based derivative colorimetric and fluorescent sensor (1), 4-dimethylamino-benzoic acid (2-imidazole formaldehyde)-hydrazide, was obtained for the detection of Cu2+ and S2?. The compound 1 exhibited dual spectral responses to Cu2+, that is, vivid color change and fluorescence enhancement in the presence of Cu2+. The detection limits were valued as 0.46 μM and 15 nM according to absorption and fluorescent response, respectively. Both of them are below the World Health Organization (WHO) guidelines for drinking water (31.5 μM). In addition, the ensemble (1-Cu2+) selectively and sensitively detected a low concentration of S2?. As the addition of S2? instantly removed Cu2+ from the ensemble (1-Cu2+) resulting in a color change from yellow to colorless and a “turn-off” fluorescent response. The detection limit for S2? was estimated as 0.12 μM (from fluorescent method) and 0.68 μM (from absorption method), respectively, each of which was also lower than the maximum allowable level of S2? (15 μM) in drinking water defined by the WHO. The binding process was confirmed via UV–vis absorption, fluorescence measurements, 1H NMR, mass spectroscopy and density functional theory calculation. What's more, successful practical application of test paper is used to inspect the S2? which means the convenient and rapid assay in real samples can be achieved.

A chromone hydrazide Schiff base fluorescence probe with high selectivity and sensitivity for the detection and discrimination of human serum albumin (HSA) and bovine serum albumin (BSA)

The discrimination and identification of human serum albumin (HSA) and bovine serum albumin (BSA) is very important, which is due to the vital roles of two SAs in biological and pharmaceutical research. Based on structural screening and docking calculation from a series of homologues, a coumarin Schiff base fluorescent probe 3-hydroxy-N′-((4-oxo-4H-chromen-3-yl)methylene)-2-naphthohydrazide (HCNH) has been designed and synthesized, which could effectively discriminate HSA and BSA. The probe HCNH exhibited superior sensitivity toward HSA and BSA with the detection limits of 10.62 nM and 16.03 nM in PBS solution, respectively. The binding mechanism of HCNH with SAs was studied by Job's plot analysis, SA destruction and displacement assay. Molecular docking and DFT methods were utilized to provide deep insight into the spatial conformation change of HCNH and binding sites in HSA/BSA. The conformation of HCNH was significantly influenced by the microenvironment provided by HSA and BSA, therefore its fluorescence emission was affected correspondingly. Non-toxic probe HCNH could be successfully used for fluorescence bio-imaging of HSA in cancer cells, which is significantly different from normal cells and favors the application in medical diagnosis.

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

The development of coumarin Schiff base system applied as highly selective fluorescent/colorimetric probes for Cu2+ and tumor biomarker glutathione detection

Overexpression of tumor biomarker glutathione (GSH) has been documented in numerous types of cancers, therefor GSH-activated light-up chemosensors for tumor identification require great attention. A new colorimetric/fluorescent probe (7-(diethylamino)-2-oxo-2H-chromen-3-yl)methylene)-4-(dimethylamino) benzohydrazide (HL) was prepared, which could be applied in discriminating Cu2+ and further recognizing GSH based on its Cu complex. Firstly, the probe HL toward Cu2+ exhibited selective fluorescence quenching and obvious color change from yellow to orange-red under visible light. Further, when GSH was introduced to the Cu2+-2HL system, the fluorescence recovered rapidly due to the high affinity of GSH to Cu2+, meanwhile the color reverted back to former yellow. Based on fluorescence titration, the detection limits were calculated as 2.40 × 10?8 M and 1.29 × 10?7 M for Cu2+ and GSH, respectively. The combination mode of HL with Cu2+ was investigated in detail by Job plots, ESI-MS, FT-IR, and DFT studies. Probes HL and Cu2+-2HL showed relatively less toxicity and were employed for biological imaging in cells and zebrafish. Remarkably, the detection for endogenous GSH by this developed sensor platform implied great potential application prospect in cancer diagnosis.