619-84-1 Usage
Description
4-Dimethylaminobenzoic acid, also known as a substituted benzoic acid, is a light grey powder that plays a crucial role in inhibiting ultraviolet (UV) mediated damage to the skin. It is a biotransformation product of 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP), which is a widely used UV filter in sunscreen cosmetics and other cosmetic products.
Uses
Used in Cosmetics Industry:
4-Dimethylaminobenzoic acid is used as a UV filter for protecting the skin from harmful ultraviolet radiation. It serves as an inhibitor of UV-mediated damage, which can lead to skin aging, sunburn, and an increased risk of skin cancer.
Used in Sunscreen Products:
4-Dimethylaminobenzoic acid is used as an active ingredient in sunscreens to provide broad-spectrum protection against both UVA and UVB rays. Its presence in sunscreen formulations helps to prevent skin damage and reduce the risk of skin cancer caused by excessive sun exposure.
Used in Skin Care Products:
In addition to sunscreens, 4-Dimethylaminobenzoic acid is also utilized in various skin care products designed to protect and nourish the skin. It can be found in moisturizers, anti-aging creams, and other skincare formulations that aim to shield the skin from the detrimental effects of UV radiation.
Used in Research and Development:
4-Dimethylaminobenzoic acid is employed in the research and development of new cosmetic products and formulations. Its UV-filtering properties make it a valuable component in the creation of innovative skincare and sun protection products that cater to the evolving needs of consumers.
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 1807, 1960 DOI: 10.1021/jo01080a035
Purification Methods
Crystallise the acid from EtOH/water. [Beilstein 14 IV 1164.]
Check Digit Verification of cas no
The CAS Registry Mumber 619-84-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 619-84:
(5*6)+(4*1)+(3*9)+(2*8)+(1*4)=81
81 % 10 = 1
So 619-84-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO2/c1-10(2)8-5-3-7(4-6-8)9(11)12/h3-6H,1-2H3,(H,11,12)/p-1
619-84-1Relevant articles and documents
Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer
Tan, Wen-Yun,Lu, Yi,Zhao, Jing-Feng,Chen, Wen,Zhang, Hongbin
supporting information, p. 6648 - 6653 (2021/09/08)
The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
Cleavage of Carboxylic Esters by Aluminum and Iodine
Sang, Dayong,Yue, Huaxin,Fu, Yang,Tian, Juan
, p. 4254 - 4261 (2021/03/09)
A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.
1,2-Dibutoxyethane-Promoted Oxidative Cleavage of Olefins into Carboxylic Acids Using O2 under Clean Conditions
Ou, Jinhua,Tan, Hong,He, Saiyu,Wang, Wei,Hu, Bonian,Yu, Gang,Liu, Kaijian
, p. 14974 - 14982 (2021/10/25)
Herein, we report the first example of an effective and green approach for the oxidative cleavage of olefins to carboxylic acids using a 1,2-dibutoxyethane/O2 system under clean conditions. This novel oxidation system also has excellent functional-group tolerance and is applicable for large-scale synthesis. The target products were prepared in good to excellent yields by a one-pot sequential transformation without an external initiator, catalyst, and additive.