17878-44-3

Basic information

• Product Name: (4-BROMOPHENOXY)TRIMETHYLSILANE
• Synonyms: 4-(TRIMETHYLSILYLOXY)BROMOBENZENE;4-BROMOTRIMETHYLSILOXYBENZENE;(4-BROMOPHENOXY)TRIMETHYLSILANE;4-Bromophenoxytrimethylsilane4-Trimethylsiloxy bromobenzol;1-BROMO-4-(TRIMETHYLSILOXY)BENZENE;p-Bromophenoxytrimethylsilane;p-Trimethylsiloxy bromobenzene;4-(Trimethylsilyloxy)bromobenzene 98%
• CAS NO: 17878-44-3
• Molecular Formula: C₉H₁₃BrOSi
• Molecular Weight: 245.19
• EINECS: 241-831-0
• Mol File: 17878-44-3.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 106 °C
• Flash Point: 207 °F
• Appearance: /
• Density: 1.268 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.216mmHg at 25°C
• Refractive Index: n20/D 1.515(lit.)
• Sensitive: Moisture Sensitive
• BRN: 1342373
• CAS DataBase Reference: (4-BROMOPHENOXY)TRIMETHYLSILANE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOPHENOXY)TRIMETHYLSILANE(17878-44-3)
• EPA Substance Registry System: (4-BROMOPHENOXY)TRIMETHYLSILANE(17878-44-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 17878-44-3(Hazardous Substances Data)

Usage

General Description

"(4-Bromophenoxy)trimethylsilane" is a chemical compound with the molecular formula C9H13BrOSi. The presence of the bromine atom in the structure makes it suitable for use in cross-coupling reactions, a common process in the field of organic synthesis. Furthermore, the silane moiety enhances its volatility, making it an ideal candidate for vapor deposition processes utilized in coating and semiconductor industries. (4-Bromophenoxy)trimethylsilane also demonstrates compatibility with various solvents and reagents, allowing for diversity in chemical reactions. Its handling and storage require caution due to its potential volatility and reactivity.

InChI:InChI=1/C9H13BrOSi/c1-12(2,3)11-9-6-4-8(10)5-7-9/h4-7H,1-3H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 106-41-2 4-bromo-phenol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 16029-98-4 trimethylsilyl iodide 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 18243-21-5 trimethylsilyl formate 
• 75-79-6 Methyltrichlorosilane 
• 13132-25-7 4-(trimethylsilyl)phenol 
• 873-75-6 4-bromobenzenemethanol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 25436-07-1 trimethylsilyl trichloroacetate 

Downstream Products

• 18036-81-2 trimethyl-(4-trimethylsilanyloxy-phenyl)-silane 
• 18588-84-6 dimethyl-bis-(4-trimethylsilanyloxy-phenyl)-silane 
• 13132-25-7 4-(trimethylsilyl)phenol 
• 74027-99-9 4-Hydroxyphenyl-dimethyl-phenylsilan 
• 74027-98-8 Dimethyl-phenyl-(4-bromphenoxy)-silan 
• 651035-36-8 1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-hydroxybenzene 
• 269409-70-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 2915-36-8 α,ω-bis(4-hydroxyphenyl)dimethylsilane 
• 18388-87-9 trimethyl-(trans-4-trimethylsilanyloxy-cyclohexyl)-silane 
• 18388-87-9 trimethyl-(cis-4-trimethylsilanyloxy-cyclohexyl)-silane 
• 57263-24-8 2-[1-hydroxy-2,2,4,4-tetramethyl-3-(4-pyridin-2-yl-piperazin-1-yl)-cyclobutyl]-phenol 
• 111574-66-4 (p-trimethylsiloxyphenyl)trimethyltin 
• 98-54-4 para-tert-butylphenol 
• 4167-74-2 4-isobutylphenol 

Relevant articles and documents

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KF/clinoptilolite NPs: An efficient and heterogeneous catalyst for chemoselective silylation of alcohols and phenols

Potassium fluoride incorporated on clinoptilolite nanoparticles (KF/CP NPs) by ion exchanging is found to be an effective and inexpensive heterogeneous nanocatalyst for chemoselective silylation of alcohols and phenols with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) at room temperature. Nano-powder of clinoptilolite (CP) was prepared using a planetary ball mill mechanically method and characterized by dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscope (SEM) analyses. Almost all of products were obtained in high yields as well as short reaction times and the catalyst was also reused eight times without loss of its catalytic activity.

Preparation method of hydroxyphenylboronic acid

The invention discloses a preparation method of hydroxyphenylboronic acid, which belongs to the technical field of boric acid synthesis in medical intermediates. The method comprises the following steps: starting from bromophenol, carrying out BOC, trimethylsilyl or benzyl protection, forming a Grignard reagent, reacting with borate, or carrying out one-pot reaction with borate and n-butyllithium,and hydrolyzing to obtain hydroxyphenylboronic acid. According to the invention, cheap and easily available protecting groups are adopted, so that the protecting groups are easy to remove during boronation reaction hydrolysis, industrial amplification is easy to realize, batch production is carried out on the scale of dozens of kilograms, and the process stability is good.