171336-79-1

Basic information

• Product Name: 2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2S-cis)-(9CI)
• Synonyms: 2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2S-cis)-(9CI)
• CAS NO: 171336-79-1
• Molecular Formula: C6H10N2O4
• Molecular Weight: 174.15
• Product Categories: PYRROLE
• Mol File: 171336-79-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.511±0.06 g/cm3(Predicted)
• PKA: 1.24±0.40(Predicted)
• CAS DataBase Reference: 2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2S-cis)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2S-cis)-(9CI)(171336-79-1)
• EPA Substance Registry System: 2,4-Pyrrolidinedicarboxylicacid,4-amino-,(2S-cis)-(9CI)(171336-79-1)

Safety Data

• Hazardous Substances Data: 171336-79-1(Hazardous Substances Data)

Usage

Chemical classification

Amino acid

Biological activity

Plays a role in the synthesis of proteins

Involvement in metabolic processes

A key component of the urea cycle in the liver

Industrial applications

Building block in the production of pharmaceuticals, agrochemicals, and other organic compounds

Physical form

Not provided in the material

Solubility

Not provided in the material

Melting point

Not provided in the material

Boiling point

Not provided in the material

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 171336-75-7 (2S,4S)-4-amino-1-benzyl-4-carboxyproline 
• 154342-89-9 (2S)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate 
• 154342-88-8 (2S,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 179030-57-0 (2S,4S)-4-tert-Butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 171192-72-6 (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 171192-74-8 (2R)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate 
• 132666-67-2 (2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate 
• 171336-78-0 (2R,4S)-4-amino-1-benzyl-4-carboxyproline 
• 171336-72-4 (2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin 
• 171336-77-9 (2S,4R)-4-amino-1-benzyl-4-carboxyproline 
• 174266-82-1 diethyl (2R,4R)-4-(tert-butyloxycarbonylamino)pyrrolidine-2,4-dicarboxylate 
• 171336-76-8 (2R,4R) 4-amino-1-(benzyl)-pyrrolidine-2,4-dicarboxylic acid 
• 178963-36-5 (2S,4S)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid diethyl ester 

Relevant articles and documents

Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC - an apparent mGluR6 selective ligand

The synthesis of the 1-benzyl derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-benzyl-APDC) starting from cis-4-hydroxy-D-proline is disclosed together with a study of the activity of this compound at metabotropic glutamate receptors (mGl

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyproline: Novel conformationally restricted glutamic acid analogues

Asymmetric syntheses of all four isomers of 4-amino-4-carboxyprolines, i.e. (2S,4S)-3, (2S,4R)-4, and their corresponding enantiomers, as novel conformationally restricted analogues of glutamic acid, were performed from trans-4-hydroxy-L-proline as a homochiral starting material. The key step was the spirohydantoin ring formation by employing the Bucherer-Bergs reaction of 4-oxoproline derivatives. These structures were determined by NMR studies.