157017-41-9

Basic information

• Product Name: 1H-Pyrrole, 1-(2-iodophenyl)-
• CAS NO: 157017-41-9
• Molecular Formula: C10H8IN
• Molecular Weight: 269.085
• Mol File: 157017-41-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(2-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(2-iodophenyl)-(157017-41-9)
• EPA Substance Registry System: 1H-Pyrrole, 1-(2-iodophenyl)-(157017-41-9)

Safety Data

• Hazardous Substances Data: 157017-41-9(Hazardous Substances Data)

Usage

Description

1H-Pyrrole, 1-(2-iodophenyl)is a chemical compound characterized by the molecular formula C10H8IN. It is a pyrrole derivative, an aromatic heterocyclic compound that features a five-membered ring composed of four carbon atoms and one nitrogen atom. The distinctive iodophenyl group attached to the pyrrole ring endows this compound with unique properties, making it valuable for organic synthesis, pharmaceutical research, and as a reagent or building block in the creation of complex organic molecules. Studies have also explored its potential anti-cancer and anti-inflammatory properties, suggesting a promising future in medicinal chemistry.

Uses

Used in Organic Synthesis:
1H-Pyrrole, 1-(2-iodophenyl)is used as a reagent and building block for the synthesis of complex organic molecules, leveraging its unique structure and properties to facilitate the formation of desired compounds.
Used in Pharmaceutical Research:
1H-Pyrrole, 1-(2-iodophenyl)is utilized in pharmaceutical research as a potential candidate for the development of new drugs, particularly due to its studied anti-cancer and anti-inflammatory properties, which make it a subject of interest for medicinal chemists seeking novel therapeutic agents.
Used in Medicinal Chemistry:
1H-Pyrrole, 1-(2-iodophenyl)is used as a starting material or intermediate in the design and synthesis of new pharmaceuticals, where its structural features can be exploited to create molecules with specific biological activities, such as those targeting cancer cells or modulating inflammatory responses.

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 615-43-0 2-iodophenylamine 
• 332-77-4 2,5-dihydro-2,5-dimethoxyfuran 
• 635-90-5 1-phenylpyrrole 
• 109-97-7 pyrrole 
• 615-42-9 1,2-Diiodobenzene 

Downstream Products

• 796843-38-4 3-(2-(1H-pyrrol-1-yl)phenyl)prop-2-yn-1-ol 
• 796843-21-5 1-[2-(prop-1-ynyl)phenyl]pyrrole 
• 796843-40-8 1-[2-(propa-1,2-dienyl)phenyl]-1H-pyrrole 
• 796843-41-9 1-[2-(1-methylpropa-1,2-dienyl)phenyl]-1H-pyrrole 
• 796843-39-5 1-[2-(3-bromoprop-1-ynyl)phenyl]-1H-pyrrole 
• 1042073-86-8 7-(4-methylphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-88-0 7-(4-nitrophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-90-4 7-(2-nitrophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-92-6 7-(2-chlorophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-96-0 7-(2-methoxyphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-98-2 N-(2-(5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinolin-7-yl)phenyl)acetamide 
• 1042074-00-9 ethyl 3-(5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinolin-7-yl)benzoate 
• 1042074-04-3 7-(3,4,5-trimethoxyphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042074-08-7 7-(1-tosyl-1H-indol-3-yl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 

Relevant articles and documents

Synthesis of fluoren-9-ones by the palladium-catalyzed cyclocarbonylation of o-halobiaryls

The synthesis of various substituted fluoren-9-ones has been accomplished by the palladium-catalyzed cyclocarbonylation of o-halobiaryls. The cyclocarbonylation of 4′-substituted 2-iodobiphenyls produces very high yields of 2-substituted fluoren-9-ones bearing either electron-donating or electron-withdrawing substituents. 3′-Substituted 2-iodobiphenyls afford 3-substituted fluoren-9-ones in excellent yields with good regioselectivity. This chemistry has been successfully extended to polycyclic fluorenones and fluorenones containing fused isoquinoline, indole, pyrrole, thiophene, benzothiophene, and benzofuran rings.

Scalable electrochemical synthesis of diaryliodonium salts

Cyclic and acyclic diaryliodonium are synthesised by anodic oxidation of iodobiaryls and iodoarene/arene mixtures, respectively, in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chemical oxidants and generates no chemical waste. More than 30 cyclic and acyclic diaryliodonium salts with different substitution patterns were prepared in very good to excellent yields. The reaction was scaled-up to 10 mmol scale giving more than four grams of dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate (>95%) in less than three hours. The solvent mixture of the large-scale experiment was recovered (>97%) and recycled several times without significant reduction in yield.

Synthesis of indolizine derivatives containing eight-membered rings: Via a gold-catalyzed two-fold hydroarylation of diynes

A gold-catalyzed method for the construction of indolizines with eight-membered rings has been developed. The reaction proceeded through a two-fold hydroarylation with indole or pyrrole derivatives containing a 1,6-diyne using a tri(1-adamantyl)phosphine