615-42-9 Usage
Description
1,2-Diiodobenzene, also known as ortho-diiodobenzene, is an organic compound with the chemical formula C6H4I2. It is a clear yellow to brownish liquid that is widely used in various chemical reactions and processes due to its unique properties. The photolysis of 1,2-diiodobenzene has been studied in different solvents such as cyclohexane, furan, and benzene, as well as in the presence of tetraphenylcyclopentadienone.
Uses
1. Used in the Suzuki Reaction:
1,2-Diiodobenzene is used as a reactant in the Suzuki reaction, a widely employed cross-coupling reaction in organic chemistry. This reaction involves the formation of carbon-carbon bonds, which are crucial for the synthesis of various complex organic molecules, including pharmaceuticals and advanced materials.
2. Used in the Synthesis of Purino[8,9-f] Phenanthridines:
1,2-Diiodobenzene serves as a key intermediate in the synthesis of purino[8,9-f] phenanthridines, a class of compounds with potential applications in medicinal chemistry and drug discovery.
3. Used as a Precursor for the Synthesis of Active Pharmaceutical Ingredients (APIs) Intermediate:
Due to its unique chemical properties, 1,2-diiodobenzene is used as a precursor in the synthesis of intermediates for active pharmaceutical ingredients. These intermediates are essential building blocks for the development of new drugs and therapies.
4. Used in the Chemical Industry:
1,2-Diiodobenzene is utilized in various chemical processes and reactions within the chemical industry, contributing to the production of a wide range of products, from specialty chemicals to advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 615-42-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 615-42:
(5*6)+(4*1)+(3*5)+(2*4)+(1*2)=59
59 % 10 = 9
So 615-42-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4I2/c7-5-3-1-2-4-6(5)8/h1-4H
615-42-9Relevant articles and documents
Generation of Organozinc Reagents from Arylsulfonium Salts Using a Nickel Catalyst and Zinc Dust
Yamada, Kodai,Yanagi, Tomoyuki,Yorimitsu, Hideki
, p. 9712 - 9718 (2021/01/09)
Readily available aryldimethylsulfonium triflates react with zinc powder under nickel catalysis via the selective cleavage of the sp2-hybridized carbon-sulfur bond to produce salt-free arylzinc triflates under mild conditions. This zincation displays superb chemoselectivity and thus represents a protocol that is complementary or orthogonal to existing methods. The generated arylzinc reagents show both high reactivity and chemoselectivity in palladium-catalyzed and copper-mediated cross-coupling reactions.
Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide
Mukhopadhyay, Sushobhan,Batra, Sanjay
supporting information, p. 14622 - 14626 (2018/09/21)
A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.
Aryne Insertion into I-I σ-Bonds
Rodriguez-Lojo, Diego,Cobas, Agustin,Pena, Diego,Perez, Dolores,Guitian, Enrique
supporting information; experimental part, p. 1363 - 1365 (2012/05/20)
A new protocol for the efficient synthesis of o-diiodoarenes has been developed. This method allows the synthesis of substituted and polycyclic o-diiodoarenes, which are difficult to obtain by classical methods. This diiodination process involves the formal insertion of arynes into the I-I σ-bond.
