1517-63-1

Basic information

• Product Name: 4-Methylbenzhydrol
• Synonyms: 4-Methylbenzhyldrol;4-Methyldiphenylmethanol~Phenyl p-tolyl carbinol;alpha-p-tolylbenzyl alcohol;4-Methylbenzhydrol, 98+%;PHENYL-4-METHYLPHENYLMETHANOL;p-Methylbenzhydrol;Benzenemethanol, 4-methyl-alpha-phenyl-;4-Methylbenzhydryl alcohol
• CAS NO: 1517-63-1
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26
• EINECS: 216-171-1
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 1517-63-1.mol
• Article Data: 258

Chemical Properties

• Melting Point: 50-54 °C(lit.)
• Boiling Point: 295.58°C (rough estimate)
• Flash Point: >230 °F
• Appearance: white to off-white powder
• Density: 1.0074 (rough estimate)
• Vapor Pressure: 4.89E-05mmHg at 25°C
• Refractive Index: 1.5381 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.68±0.20(Predicted)
• BRN: 2048849
• CAS DataBase Reference: 4-Methylbenzhydrol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylbenzhydrol(1517-63-1)
• EPA Substance Registry System: 4-Methylbenzhydrol(1517-63-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 1517-63-1(Hazardous Substances Data)

Usage

Description

4-Methylbenzhydrol, also known as 4-Methyl-α-phenylbenzenemethanol, is a white to off-white powder with distinct chemical properties. It is an organic compound that has found applications in various fields due to its unique structure and properties.

Uses

Used in Pharmaceutical Industry:
4-Methylbenzhydrol is used as a synthetic intermediate for the development of tropane analogs, which are crucial in the inhibition of binding at the dopamine transporter. This application is significant in the research and treatment of various neurological and psychiatric disorders related to dopamine dysregulation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-Methylbenzhydrol is utilized in Structure-Activity Relationship (SAR) studies. These studies focus on diphenylpiperazine N-type calcium channel inhibitors, which are essential in understanding and developing potential therapeutic agents for various conditions, including pain management and anti-hyperalgesic activity.
Overall, 4-Methylbenzhydrol plays a vital role in the synthesis of compounds and the advancement of research in the pharmaceutical and medicinal chemistry industries, contributing to the development of new drugs and therapies for various medical conditions.

InChI:InChI=1/C14H14O/c1-11-7-9-13(10-8-11)14(15)12-5-3-2-4-6-12/h2-10,14-15H,1H3/t14-/m1/s1

Upstream product

• 808-12-8 1,2-bis(4-methylphenyl)-1,2-diphenyl-1,2-ethanediol 
• 103-73-1 Phenetole 
• 134-84-9 4-Methylbenzophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 130318-72-8 methyldiphenyltelluronium tetraphenylborate 
• 103145-60-4 C₇H₇IYb 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 108-86-1 bromobenzene 
• 934-56-5 trimethyl(phenyl)stannane 
• 100-58-3 phenylmagnesium bromide 
• 779-14-6 p-methyl-a-phenylbenzylchloride 
• 64-17-5 ethanol 
• 1078-58-6 diphenylzinc 
• 38651-11-5 1-(bromo(phenyl)methyl)-4-methylbenzene 

Downstream Products

• 113181-46-7 1-methyl-4-((phenyl(p-tolyl)methyl)sulfonyl)benzene 
• 130163-27-8 2,3-diphenyl-2,3-di-p-tolyl-oxirane 
• 57272-11-4 1-azido-1-(4-methylphenyl)-1-phenylmethane 
• 134-84-9 4-Methylbenzophenone 
• 42289-57-6 α-p-tolylbenzyl cation 
• 1517-63-1 (-)-p-Methylbenzhydrol 
• 23010-14-2 (4-methylphenyl)(phenyl)methyl acetate 
• 18552-78-8 2-(Phenyl-p-tolyl-methoxy)-acetamide 
• 18552-79-9 N-Carbamoylmethyl-2-(phenyl-p-tolyl-methoxy)-acetamide 
• 1517-63-1 (R)-(4-Methylphenyl)phenylmethanol 
• 24218-12-0 (S)-(4-Methylphenyl)phenylmethanol 
• 38379-42-9 phthalic acid mono-((R)-4-methyl-benzhydryl ester) 
• 73803-55-1 phthalic acid mono-((S)-4-methyl-benzhydryl ester) 
• 119841-49-5 tri-n-butylstannyl alkoxide of p-methylbenzhydrol 

Relevant articles and documents

-

-

Rhodium-catalyzed 1,2-addition of Sb-phenyl-1,5-azastibocines to functionalized aldehydes

Simple and efficient addition of a phenyl group to aldehydes was accomplished by the rhodium-catalyzed reaction of Sb-phenyl-1,5-azastibocines. Because of the soft nucleophilic character of 1,5-azastibocines, arylation of functionalized aldehydes having ketone, ester, and halogen moieties can be achieved to afford aryl alcohols. The reaction can be carried out under aerobic conditions, in striking contrast to the reactions with hard nucleophiles such as organolithium and Grignard reagents.

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

Melamine-Based Porous Organic Polymers Supported Pd(II)-Catalyzed Addition of Arylboronic Acids to Aromatic Aldehydes

Abstract: A new type melamine-based porous organic polymers (SZU-1) has been synthesized with melamine and 2,2′-bipyridyl-5,5′-dialdehyde by a one-pot method and fully characterized. Divalent palladium salts were coordinated to this polymer network which successfully catalyzed the nucleophilic addition reaction of arylboronic acids to aromatic aldehydes. With only 1.0?mol% heterogeneous catalyst loading, high reaction yields (>?85%) can be achieved in most cases. The scope of substrates was also investigated and the catalyst showed universal applicability. Graphic Abstract: The loose and porous melamine-based porous organic polymers (SZU-1) are synthesized by melamine and 2,2′-bipyridyl-5,5′-dialdehyde. The performance of SZU-1 was characterized and most of the substrates achieved high yield (> 85%) in the catalytic performance test.[Figure not available: see fulltext.]

Enantioselective Synthesis of Bicyclopentane-Containing Alcohols via Asymmetric Transfer Hydrogenation

Compounds a containing bicyclo[1.1.1]pentane (BCP) adjacent to a chiral center can be prepared with high enantiomeric excess through asymmetric transfer hydrogenation (ATH) of adjacent ketones. In the reduction step, the BCP occupies the position distant from the η6-arene of the catalyst. The reduction was applied to the synthesis of a BCP analogue of the antihistamine drug neobenodine.