146144-48-1 Usage
Description
(3R)-3-[[2-[(3R)-2-oxo-3-[2-(4-piperidyl)ethyl]-1-piperidyl]acetyl]amino]butanoic acid, also known as L-659,699, is a synthetic chemical compound with potential pharmaceutical applications. It is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and acts as a selective GABA-B antagonist. Its structure and pharmacological properties make it a subject of interest for research in the field of neuropharmacology.
Uses
Used in Pharmaceutical Industry:
(3R)-3-[[2-[(3R)-2-oxo-3-[2-(4-piperidyl)ethyl]-1-piperidyl]acetyl]amino]butanoic acid is used as a GABA-B antagonist for its potential therapeutic effects on mood disorders, schizophrenia, and other conditions related to GABA transmission in the central nervous system. Its selective action on GABA-B receptors makes it a promising candidate for the development of new treatments for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 146144-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,1,4 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 146144-48:
(8*1)+(7*4)+(6*6)+(5*1)+(4*4)+(3*4)+(2*4)+(1*8)=121
121 % 10 = 1
So 146144-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H31N3O4/c1-13(11-17(23)24)20-16(22)12-21-10-2-3-15(18(21)25)5-4-14-6-8-19-9-7-14/h13-15,19H,2-12H2,1H3,(H,20,22)(H,23,24)/t13-,15+/m1/s1
146144-48-1Relevant articles and documents
Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist
Duggan, Mark E.,Naylor-Olsen, Adel M.,Perkins, James J.,Anderson, Paul S.,Chang, Charles T.-C.,et al.
, p. 3332 - 3341 (1995)
The design, synthesis, and pharmacological evaluation of L-734,217, a potent, low-molecular weight, orally active fibrinogen receptor antagonist, is reported.A strategy for producing low-molecular weight inhibitors from the peptide c-A, previou
Asymmetric hydrogenation of 3-alkylidene-2-piperidones using Noyori's catalyst. Effect of N-substituents on the enantioselectivity
Chung, John Y. L.,Zhao, Dalian,Hughes, David L.,McNamara, James M.,Grabowski, Edward J. J.,Reider, Paul J.
, p. 7379 - 7382 (2007/10/02)
The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene-2-piperidones catalyzed by BINAP-Ru(II) complex was found to be significantly effected by the internal substituents on the lactam nitrogen, affording the corresponding 3-alkyl-2-piperidones in 52-92% ee.