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1346242-81-6

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1346242-81-6 Usage

Description

JNJ-42756493 is a compound with potential applications in various industries, including pharmaceuticals and drug delivery systems. It is characterized by its unique chemical properties and interactions with biopolymers and macromolecules.

Uses

Used in Pharmaceutical Industry:
JNJ-42756493 is used as a therapeutic agent for [application reason], such as targeting specific biological pathways or modulating cellular processes. Its chemical properties allow it to interact with biopolymers and macromolecules, making it a promising candidate for the development of new drugs and therapies.
Used in Drug Delivery Systems:
JNJ-42756493 is used as a component in the development of novel drug delivery systems, such as organic and metallic nanoparticles. These systems aim to improve the delivery, bioavailability, and therapeutic outcomes of various drugs, including those used in the treatment of cancer and other diseases.

History

In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 1346242-81-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,2,4 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1346242-81:
(9*1)+(8*3)+(7*4)+(6*6)+(5*2)+(4*4)+(3*2)+(2*8)+(1*1)=146
146 % 10 = 6
So 1346242-81-6 is a valid CAS Registry Number.

1346242-81-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine

1.2 Other means of identification

Product number -
Other names JNJ-42756493

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1346242-81-6 SDS

1346242-81-6Relevant articles and documents

SOLID STATE FORMS OF ERDAFITINIB SALTS AND PROCESSES FOR PREPARATION OF ERDAFITINIB

-

, (2022/03/07)

The present disclosure relates to solid state forms of Erdafitinib salts, processes for preparation thereof, processes for preparation of Erdafitinib and pharmaceutical compositions thereof.

Preparation method of 3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxaline amine

-

, (2021/01/04)

The invention discloses a preparation method of erlotinib intermediate 3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxaline amine. According to the preparation method of the invention, 2, 4-dinitroaniline is adopted as an initial raw material, and basic unit reactions such as substitution, reductive cyclization, oxidation, condensation and the like are sequentially carried out to obtain the target intermediate. The preparation process has the advantages of easily available raw materials, rapidness, convenience, economy and environmental protection, is suitable for large-scale production, and provides anew preparation way for industrialization of erlotinib.

Preparation method of Erdafitinib intermediate

-

, (2020/12/31)

The invention discloses a preparation method of an Erdafitinib intermediate 3-(1-methyl-1H-pyrazole-4-yl)-6-quinoxaline amine. The method comprises the steps of by using 2, 4-dinitroaniline as an initial raw material, sequentially carrying out condensation, reduction, cyclization and other basic unit reactions to obtain the target intermediate. The preparation process has the advantages of easilyavailable raw materials, rapidness, convenience, economy and environmental protection, is suitable for large-scale production, and provides a new preparation way for industrialization of Erdafitinib.

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