875-51-4

Basic information

• Product Name: 4-Bromo-2-nitroaniline
• Synonyms: 4-bromo-2-nitro-anilin;4-BROMO-2-NITRO-PHENYLAMINE;4-BROMO-2-NITROANILINE;4-BROMO-2-NITROBENZENAMINE;BUTTPARK 29\04-55;TIMTEC-BB SBB003381;1-Amino-4-bromo-2-nitrobenzene;4-Bromo-o-nitroaniline
• CAS NO: 875-51-4
• Molecular Formula: C₆H₅BrN₂O₂
• Molecular Weight: 217.02
• Product Categories: Amines and Anilines;Anilines, Aromatic Amines and Nitro Compounds;Amines;Phenyls & Phenyl-Het;Anilines, Amides & Amines;Bromine Compounds;Nitro Compounds;Phenyls & Phenyl-Het;C2 to C6;Nitrogen Compounds
• Mol File: 875-51-4.mol
• Article Data: 68

Chemical Properties

• Melting Point: 110-113 °C(lit.)
• Boiling Point: 308.7 °C at 760 mmHg
• Flash Point: 140.5 °C
• Appearance: /
• Density: 1.7917 (rough estimate)
• Vapor Pressure: 0.000151mmHg at 25°C
• Refractive Index: 1.5150 (estimate)
• Storage Temp.: Room temperature.
• Solubility: Chloroform, DMSO, Methanol
• PKA: -1.05±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-nitroaniline(875-51-4)
• EPA Substance Registry System: 4-Bromo-2-nitroaniline(875-51-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43-20/21/22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• RTECS: BW9370000
• TSCA: Yes
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 875-51-4(Hazardous Substances Data)

Usage

Description

4-Bromo-2-nitroaniline is an organic compound that consists of an aniline molecule with a bromine atom at the 4-position and a nitro group at the 2-position. It is a yellow crystalline solid and is commonly used as an intermediate in the synthesis of various chemical compounds.

Uses

Used in Chemical Synthesis:
4-Bromo-2-nitroaniline is used as a chemical intermediate for the synthesis of reagents such as ethyltriphenylphosphonium tribromide. This reagent is utilized in various applications, including the synthesis of new compounds and the development of novel materials.
Used in Pharmaceutical Industry:
4-Bromo-2-nitroaniline is used as a building block in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Dye Industry:
4-Bromo-2-nitroaniline is used as a precursor in the production of dyes and pigments. Its ability to form various chemical compounds makes it a valuable component in the creation of a wide range of colors.
Used in Research and Development:
4-Bromo-2-nitroaniline is used in research and development for the study of chemical reactions and the development of new synthetic methods. Its versatility as a chemical intermediate makes it an important tool for chemists working in various fields.

InChI:InChI=1/C6H5BrN2O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,8H2

Synthetic route

2-nitro-aniline (88-74-4) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With hydrogen bromide; dihydrogen peroxide In methanol at 0 - 20℃; for 12h;	99%
With HMTAB In dichloromethane at 20℃; for 0.5h;	98%
With 1-butyl-3-methylpyridinium tribromide at 20℃;	98%

4-nitro-N-(4-bromo-2-nitrophenyl)benzenesulfonamide → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With potassium carbonate; dimethyl sulfoxide; thiophenol In acetonitrile at 100℃; for 24h;	96%

N-(2-nitro-4-bromophenyl) 2-pyridinecarboxamide → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With sodium hydroxide In ethanol at 90℃; for 8h;	92%

N-(4-bromo-2-nitrophenyl)acetamide

Conditions	Yield
With potassium hydroxide In ethanol at 80℃; for 12h;	86%
With hydrogenchloride In tetrahydrofuran Heating;	77%
With hydrogenchloride

2-nitro-aniline (88-74-4) → 2-bromo-6-nitroaniline (59255-95-7) + 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With dihydrogen peroxide; potassium bromide In water; acetonitrile	A 15% B 82%
With dihydrogen peroxide; potassium bromide; HZSM-5 In acetic acid at 20℃; for 4h; Bromination;	A 15% B 77%
With N-Bromosuccinimide; acetic acid at 34.84 - 89.84℃; for 5.5h;	A 6.81 g B 74%
With dihydrogen peroxide; ammonium bromide; acetic acid at 20℃; for 4h;
Stage #1: 2-nitro-aniline With dihydrogen peroxide; acetic acid; potassium bromide In water at 20℃; for 3h; Stage #2: With sodium hydrogencarbonate In diethyl ether; water regioselective reaction;

4-bromo-aniline (106-40-1) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one In trifluoroacetic acid for 3h; Ambient temperature;	70%
With nitric acid; acetic acid
Multi-step reaction with 3 steps 1: Diazotization.Zersetzung des Diazoniumperbromids mit Alkohol 2: beim Nitrieren 3: alcohol; ammonia / 200 - 210 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane 2: nitric acid; acetic anhydride / dichloromethane 3: hydrogenchloride / water / Reflux View Scheme
Multi-step reaction with 3 steps 1: pyridine / tetrahydrofuran / 16 h / 20 °C / Cooling with ice 2: nitric acid; copper(II) nitrate hydrate; oxygen / acetonitrile; water / 4 h / 50 °C / 760.05 Torr 3: potassium carbonate; dimethyl sulfoxide; thiophenol / acetonitrile / 24 h / 100 °C View Scheme

N-(4-bromo-2-nitrophenyl) pyrimidin-2-amine → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Stage #1: N-(4-bromo-2-nitrophenyl) pyrimidin-2-amine With triethylsilane; trifluoroacetic acid at 50℃; Inert atmosphere; Stage #2: With acetic acid; hydrazine In methanol at 20℃; Inert atmosphere; regioselective reaction;	68%

4’-methoxy-2-nitroazobenzene (35527-28-7) → 4-Bromo-2-nitroaniline (875-51-4) + 2,4-dibromo-6-nitroaniline (827-23-6) + 2-nitro-aniline (88-74-4)

Conditions	Yield
With hydrogen bromide In acetic acid for 1h; Heating;	A 51% B 10% C 22%

2-(4-bromophenyl)isoindoline-1,3-dione (40101-31-3) → 4-Bromo-2-nitroaniline (875-51-4) + 4-bromo-3-nitroaniline (53324-38-2)

Conditions	Yield
With sulfuric acid; nitric acid Erhitzen des Reaktionsprodukts mit 90prozentig.wss.Schwefelsaeure auf 130grad;

1,4-dibromo-2-nitrobenzene (3460-18-2) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With ammonia; ethylene glycol at 120 - 130℃;
With ethanol; ammonia at 200 - 210℃;

4-bromo-1-chloro-2-nitrobenzene (16588-24-2) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With ethanol; ammonia at 160℃;

→ 4-Bromo-2-nitroaniline

Conditions	Yield
Bromieren und Verseifung des Reaktionsproduktes;

4-Bromo-1-fluoro-2-nitrobenzene → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With ammonium hydroxide

acetic acid-(N-bromo-2-nitro-anilide) (99233-17-7) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With water

N-(4-bromophenyl)-nitramine (412328-47-3) → 4-Bromo-2-nitroaniline (875-51-4)

(4-amino-3-nitro-phenyl)-arsonic acid (5440-06-2) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With hydrogen bromide

bromine (7726-95-6) + acetic acid (64-19-7) + 2-nitro-aniline (88-74-4) → 4-Bromo-2-nitroaniline (875-51-4)

nitric acid (7697-37-2) + acetic acid (64-19-7) + 4-bromo-aniline (106-40-1) → 4-Bromo-2-nitroaniline (875-51-4)

1,4-dibromo-2-nitrobenzene (3460-18-2) + ammonia (7664-41-7) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
at 200 - 210℃;

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) + ammonium hydroxide → 4-Bromo-2-nitroaniline (875-51-4)

N-(4-bromophenyl)-nitramine (412328-47-3) + mineral acid → 4-Bromo-2-nitroaniline (875-51-4)

2-nitro-aniline (88-74-4) → 2-bromo-6-nitroaniline (59255-95-7) + 4-Bromo-2-nitroaniline (875-51-4) + 2,4-dibromo-6-nitroaniline (827-23-6)

Conditions	Yield
With sodium perborate; ammonium heptamolybdate; potassium bromide In acetic acid at 20℃; for 1.25h; Bromination;

2-nitro-aniline (88-74-4) → 4-iodo-2-nitroaniline (20691-72-9) + 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
With sodium periodate; potassium iodide; lithium bromide In water; acetic acid at 25℃; for 8h;

4-bromoacetanilide (103-88-8) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / nitric acid / 0.17 h / -40 °C 2: 77 percent / aq. HCl / tetrahydrofuran / Heating View Scheme
Multi-step reaction with 2 steps 1: HNO3 / 8 min below 0 deg C, 8 min, RT. 2: 3N KOH / 24 h / Heating View Scheme
Multi-step reaction with 2 steps 1: alcoholic potash 2: glacial acetic acid; nitric acid View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; sodium nitrate 2: aqueous sulfuric acid View Scheme
Multi-step reaction with 2 steps 1: nitric acid; acetic anhydride / dichloromethane 2: hydrogenchloride / water / Reflux View Scheme

o-nitroacetanilide (552-32-9) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: chloroform; KHCO3; acid; bromine 2: acidified water View Scheme

bromochlorobenzene (106-39-8) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated nitric acid 2: alcohol; ammonia / 160 °C View Scheme

1.4-dibromobenzene (106-37-6) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: beim Nitrieren 2: alcohol; ammonia / 200 - 210 °C View Scheme

chlorobenzene (108-90-7) → 4-Bromo-2-nitroaniline (875-51-4)

Conditions	Yield
Multi-step reaction with 3 steps 1: bromine 2: concentrated nitric acid 3: alcohol; ammonia / 160 °C View Scheme

Å molecular sieves + dichloromethane (75-09-2) + 4-methylmorpholine N-oxide (7529-22-8) + 5-benzimidazolecarboxylic acid (15788-16-6) → 4-Bromo-2-nitroaniline (875-51-4) + 1H-benzo[d]imidazole-5-carbaldehyde (58442-17-4)

Conditions	Yield
With LiAlH4; tetrapropylammonium perruthennate In tetrahydrofuran; N,N-dimethyl-formamide	A 452 mg (32%, 2 steps) B n/a

4-Bromo-2-nitroaniline (875-51-4) + pyridine-3-boronic acid 1,3-propanediol cyclic ester → 2-nitro-4-(pyridin-3-yl)benzenamine (167959-19-5)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,2-dimethoxyethane at 90℃; for 8h; Suzuki coupling;	100%
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 90℃; for 8h;

4-Bromo-2-nitroaniline (875-51-4) + cyclopropylboronic acid (411235-57-9) → 4-cyclopropyl-2-nitro-phenylamine (335254-72-3)

Conditions	Yield
With potassium phosphate; palladium diacetate; catacxium A In water; toluene at 90℃; Inert atmosphere;	100%
With potassium phosphate; palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; for 12h; Inert atmosphere;	89%
With potassium phosphate; palladium diacetate; triphenylphosphine In toluene at 100℃; for 17h; Sealed tube;	72%

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole (832114-00-8) + 4-Bromo-2-nitroaniline (875-51-4) → 4-(3,5-dimethylisoxazol-4-yl)-2-nitroaniline

Conditions	Yield
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; caesium carbonate In 1,2-dimethoxyethane; water for 0.5h; Suzuki Coupling;	100%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere;	88%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere;	88%

Conditions	Yield
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In ethanol; water for 8h; Inert atmosphere; Reflux;	100%

4-Bromo-2-nitroaniline + acetic anhydride (108-24-7) → N-(4-bromo-2-nitrophenyl)acetamide (881-50-5)

Conditions	Yield
With acetic acid at 95℃; for 7.5h;	99.1%
With acetic acid at 100℃; for 3h;	94%
With acetic acid at 100℃; for 5h;	92.1%

CYANAMID (420-04-2) + 4-Bromo-2-nitroaniline (875-51-4) → 7-bromo-1-oxido-1,2,4-benzotriazin-1-ium-3-amine (6298-38-0)

Conditions	Yield
Stage #1: CYANAMID; 4-Bromo-2-nitroaniline at 50 - 100℃; Stage #2: With hydrogenchloride In water at 100℃; for 3h; Stage #3: With sodium hydroxide In water at 100℃; for 1h;	99%
Stage #1: CYANAMID; 4-Bromo-2-nitroaniline In diethyl ether at 100℃; for 0.5h; Stage #2: With hydrogenchloride In diethyl ether; water at 50 - 110℃; for 1h; Stage #3: With sodium hydroxide In diethyl ether; water at 50 - 110℃; for 1h;	79%
Stage #1: CYANAMID; 4-Bromo-2-nitroaniline at 100℃; for 0.5h; Stage #2: With hydrogenchloride In water at 50 - 100℃; for 3h; Stage #3: With sodium hydroxide In water at 100℃; for 1h;	60%

4-Bromo-2-nitroaniline (875-51-4) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → 4-(1-methyl-1H-pyrazol-4-yl)-2-nitroaniline (959909-79-6)

Conditions	Yield
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In ISOPROPYLAMIDE; water at 80℃; for 1h; Suzuki Coupling;	99%
With sodium carbonate In N,N-dimethyl acetamide; water at 80℃; for 1h; Inert atmosphere;	99%
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In N,N-dimethyl acetamide; water at 80℃; for 1h; Suzuki Coupling;	99%

4-Bromo-2-nitroaniline (875-51-4) + acrylic acid methyl ester (292638-85-8) → methyl (E)-3-(4′-bromo-2′-nitrophenyl)acrylate (1297609-84-7)

Conditions	Yield
With tert.-butylnitrite; methanesulfonic acid; palladium diacetate; methoxybenzene In methanol at 0 - 25℃; for 48h; Reagent/catalyst; Heck Reaction;	99%
Stage #1: 4-Bromo-2-nitroaniline With tert.-butylnitrite In methanol at 0℃; for 0.5h; Stage #2: acrylic acid methyl ester With methanesulfonic acid; palladium diacetate In methanol at 0 - 25℃; Heck-Matsuda reaction; chemoselective reaction;	98%
With palladium diacetate; toluene-4-sulfonic acid In methanol at 60℃; for 1.5h; Inert atmosphere; chemoselective reaction;	76%
With tert.-butylnitrite In methanol at 25℃; for 24h; chemoselective reaction;	74%

4-Bromo-2-nitroaniline (875-51-4) + methyl iodide (74-88-4) → N-methyl-4-bromo-2-nitroaniline (53484-26-7)

Conditions	Yield
Stage #1: 4-Bromo-2-nitroaniline With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 0 - 20℃; for 2h; Inert atmosphere;	99%

Conditions	Yield
Stage #1: 4-Bromo-2-nitroaniline With potassium hydroxide In ethanol at 47 - 65℃; for 2h; Inert atmosphere; Stage #2: With sodium hypochlorite In ethanol; water at 2 - 20℃; for 19.5h;	98%
Stage #1: 4-Bromo-2-nitroaniline With potassium hydroxide In ethanol at 60℃; for 1h; Stage #2: With sodium hypochlorite at 0℃; for 1h;
Stage #1: 4-Bromo-2-nitroaniline With potassium hydroxide In ethanol at 47 - 65℃; for 2h; Stage #2: With sodium hypochlorite In ethanol; water at 5℃; for 1.5h;

thiophene boronic acid + 4-Bromo-2-nitroaniline (875-51-4) → 2-nitro-4-thiophen-2-yl-phenylamine (405170-93-6)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 100℃; for 3h; Suzuki-Miyaura coupling;	98%
With potassium carbonate; tris-(o-tolyl)phosphine; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water Suzuki coupling;

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 4-Bromo-2-nitroaniline (875-51-4) → 1-(4-bromo-2-nitrophenyl)-1H-pyrrole (1169610-77-8)

Conditions	Yield
With acetic acid for 4h; Reflux;	98%
With acetic acid for 1h; Reflux;	86%
With acetic acid for 2h; Clauson-Kaas Synthesis; Reflux;

1,1-Diphenylmethanol (91-01-0) + 4-Bromo-2-nitroaniline (875-51-4) → N-benzhydryl-4-bromo-2-nitroaniline

Conditions	Yield
With sodium tetrachloroaurate(III) dihydrate; sodium 3-(diphenylphosphanyl)benzenesulfonate In water at 80℃; for 16h; Sealed tube; Green chemistry;	98%

4-Bromo-2-nitroaniline (875-51-4) + 2-(methylthio)benzo[d]oxazole-6-carbaldehyde → 4-bromo-N-((2-(methylthio)benzo[d]oxazol-6-yl)methyl)-2-nitroaniline

Conditions	Yield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In dichloromethane at -5 - 0℃; for 2h;	97.4%

Conditions	Yield
With iron(III) chloride; hydrazine In methanol	97%
With hydrogenchloride; tin(ll) chloride at 65 - 70℃; for 1h;	96%
With tin(ll) chloride In ethanol Reduction; Heating;	94%

+ 4-Bromo-2-nitroaniline (875-51-4) → 4-bromo-1-methylsulfanyl-2-nitro-benzene (345635-46-3)

Conditions	Yield
With isopentyl nitrite at 25 - 90℃; for 2h;	97%
With isopentyl nitrite at 80 - 90℃; for 2h;	76%

4-Bromo-2-nitroaniline (875-51-4) + isopentyl nitrite (110-46-3) → 4-bromo-1-methylsulfanyl-2-nitro-benzene (345635-46-3)

Conditions	Yield
In Dimethyldisulphide; ethyl acetate	97%

4-Bromo-2-nitroaniline (875-51-4) → 4-bromo-2-nitrobenzenediazonium tetrafluoroborate

Conditions	Yield
With tert.-butylnitrite; boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃;	97%

4-Bromo-2-nitroaniline (875-51-4) + 2-(trifluoromethyl)phenylboronic acid (1423-27-4) → 3-nitro-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine (1221349-90-1)

Conditions	Yield
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,2-dimethoxyethane; water at 90℃; for 16h; Inert atmosphere;	97%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane; water at 90℃; for 18h; Suzuki coupling; Inert atmosphere;	97%
With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 80℃; Inert atmosphere;
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,2-dimethoxyethane; water at 90℃; for 16h; Inert atmosphere;

4-Bromo-2-nitroaniline (875-51-4) + 2-trifluoromethoxyphenylboronic acid (175676-65-0) → 3-nitro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-amine (1259026-48-6)

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane; water at 90℃; for 18h; Suzuki coupling; Inert atmosphere;	97%

4-Bromo-2-nitroaniline (875-51-4) → (4-bromo-2-nitrophenyl)hydrazine hydrochloride (100032-79-9)

Conditions	Yield
Stage #1: 4-Bromo-2-nitroaniline With hydrogenchloride In water at 40℃; for 2h; Stage #2: With sodium nitrite In water at -10℃; for 2h; Stage #3: With hydrogenchloride; tin(ll) chloride In water at -30 - -20℃;	97%

4-Bromo-2-nitroaniline (875-51-4) + allyltributylstanane (24850-33-7) → 4-allyl-2-nitroaniline (160522-85-0)

Conditions	Yield
With bis(triphenylphosphine)palladium(II)-chloride; triphenylphosphine In N,N-dimethyl-formamide at 120℃;	96%

Upstream product

• 99233-17-7 acetic acid-(N-bromo-2-nitro-anilide) 
• 88-74-4 2-nitro-aniline 
• 16937-01-2 N-(4-bromophenyl)-4-nitrobenzenesulfonamide 
• 461702-59-0 N-(4-bromophenylpyrimidin)-2-amine 
• 20244-61-5 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one 
• 75-09-2 dichloromethane 
• 7529-22-8 4-methylmorpholine N-oxide 
• 15788-16-6 5-benzimidazolecarboxylic acid 
• 108-90-7 chlorobenzene 
• 106-37-6 1.4-dibromobenzene 
• 106-39-8 bromochlorobenzene 
• 552-32-9 o-nitroacetanilide 
• 103-88-8 4-bromoacetanilide 
• 412328-47-3 N-(4-bromophenyl)-nitramine 

Downstream Products

• 83665-64-9 2-[(E)-3-(4-Amino-3-nitro-phenyl)-allyl]-isoindole-1,3-dione 
• 85063-71-4 4-Bromo-1-isothiocyanato-2-nitro-benzene 
• 120703-28-8 2-nitro-4-phenylethynyl-phenylamine 
• 518982-26-8 2-nitro-4-(trimethylsilanylethynyl)phenylamine 
• 929194-33-2 7-(2,6-dichloro-phenyl)-benzo[1,2,4]triazin-3-ylamine 
• 867330-99-2 7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-ylamine 
• 867331-59-7 7-(2,6-dimethyl-phenyl)-N₃-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-benzo[1,2,4]triazine-3,5-diamine 
• 867331-58-6 [7-(2,6-dimethyl-phenyl)-5-nitro-1-oxy-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine 
• 518980-41-1 (4-iodo-3-nitrophenylethynyl)trimethylsilane 
• 302800-17-5 N-(4-bromo-2-nitrophenyl)-N-methyl methyl carbamate 
• 1026004-24-9 4-{3-[4-(4-fluoro-benzyl)-piperidin-1-yl]-prop-1-ynyl}-benzene-1,2-diamine 
• 1026421-49-7 4-{3-[4-(4-chloro-benzyl)-piperidin-1-yl]-prop-1-ynyl}-benzene-1,2-diamine 
• 1027488-62-5 4-{3-[4-(4-methoxy-benzyl)-piperidin-1-yl]-prop-1-ynyl}-benzene-1,2-diamine 
• 1027534-99-1 4-benzyl-1-[3-(3,4-diamino-phenyl)-prop-2-ynyl]-piperidin-4-ol 

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Ring size changes in the development of class I HDAC inhibitors

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.

Novel compound and organic light emitting device comprising the same

The present invention provides: a novel compound each comprising an amino group at both ends of a molecule; and an organic light emitting device comprising the same. When the compound of chemical formula 1 of the present invention is applied to the organic light emitting device, it is possible to improve efficiency, lower driving voltage, and improve lifespan characteristics of the organic light emitting device.COPYRIGHT KIPO 2020

METHOD FOR PRODUCING AROMATIC HALOGEN DERIVATIVE

PROBLEM TO BE SOLVED: To provide a highly efficient and economically advantageous method for producing a halogen compound. SOLUTION: The method produces a halogen compound represented by formula (2) (X is a halogen atom, and b is an integer of 1-5) by reacting an aniline derivative represented by formula (1) (R1 is an ester group, a carbonyl group, a nitrile group, a nitro group, an optionally substituted alkyl group or an optionally substituted aralkyl group, and a is an integer of 0-4) with a halogenating agent in the presence of a copper catalyst and a persulfate. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT