Welcome to LookChem.com Sign In|Join Free

CAS

  • or

133940-72-4

2,5-Pyrazinedicarbonitrile, 3,6-diamino-, also known as 3,6-diamino-2,5-dicyanopyrazine, is a chemical compound with the formula C6H4N6. It is a derivative of pyrazine, featuring two cyano groups and two amino groups. This white to light yellow crystalline solid is primarily utilized in the synthesis of pharmaceuticals and organic compounds. Moreover, it has potential applications in material science for developing new polymers and functional materials. Its distinctive chemical structure and properties render it a significant building block for a variety of industrial and research applications.

133940-72-4 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 133940-72-4 Structure

  • Basic information

    1. Product Name: 2,5-Pyrazinedicarbonitrile, 3,6-diamino-
    2. Synonyms: 2,5-Pyrazinedicarbonitrile, 3,6-diamino-;3,6-diaminopyrazine-2,5-dicarbonitrile;3,6-diamino-2,5-Pyrazinedicarbonitrile
    3. CAS NO:133940-72-4
    4. Molecular Formula: C6H4N6
    5. Molecular Weight: 160.14
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 133940-72-4.mol
    9. Article Data: 2

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 586.8±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.55±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: -1.00±0.10(Predicted)
    10. CAS DataBase Reference: 2,5-Pyrazinedicarbonitrile, 3,6-diamino-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,5-Pyrazinedicarbonitrile, 3,6-diamino-(133940-72-4)
    12. EPA Substance Registry System: 2,5-Pyrazinedicarbonitrile, 3,6-diamino-(133940-72-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 133940-72-4(Hazardous Substances Data)

133940-72-4 Usage

Uses

Used in Pharmaceutical Synthesis:
2,5-Pyrazinedicarbonitrile, 3,6-diaminois used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of diverse drug molecules with potential therapeutic applications.
Used in Organic Compounds Synthesis:
2,5-Pyrazinedicarbonitrile, 3,6-diaminoserves as a crucial building block in the synthesis of a range of organic compounds, contributing to the development of new chemical entities with specific properties and functions.
Used in Material Science:
2,5-Pyrazinedicarbonitrile, 3,6-diaminois used as a precursor in the development of new polymers and functional materials. Its incorporation into these materials can enhance their properties, such as conductivity, stability, or reactivity, making them suitable for various applications in different industries.
Used in Research Applications:
Due to its unique chemical structure, 2,5-Pyrazinedicarbonitrile, 3,6-diaminois employed in various research applications to explore its potential uses and properties. This includes studying its interactions with other molecules, its role in chemical reactions, and its potential as a component in new materials or drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 133940-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,9,4 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 133940-72:
(8*1)+(7*3)+(6*3)+(5*9)+(4*4)+(3*0)+(2*7)+(1*2)=124
124 % 10 = 4
So 133940-72-4 is a valid CAS Registry Number.

133940-72-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,6-diaminopyrazine-2,5-dicarbonitrile

1.2 Other means of identification

Product number -
Other names 3,6-diamino-2,5-pyrazinedicarbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133940-72-4 SDS

133940-72-4Synthetic route

2,3-diamino-3-(ethylthio)acrylonitrile

2,3-diamino-3-(ethylthio)acrylonitrile

sodium citrate
68-04-2

sodium citrate

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

Conditions
ConditionsYield
With citric acid In 1,2-dimethoxyethane; water48.7%
(2E)-2,3-diamino-3-(phenylthio)acrylonitrile

(2E)-2,3-diamino-3-(phenylthio)acrylonitrile

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

Conditions
ConditionsYield
In 1,2-dimethoxyethane; water at 20℃; for 5h; pH=3;45%
2,3-diamino-3-(4-chloro-phenylthio)acrylonitrile

2,3-diamino-3-(4-chloro-phenylthio)acrylonitrile

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

Conditions
ConditionsYield
40.3%
1-iodo-butane
542-69-8

1-iodo-butane

butyl isothiocyanate
592-82-5

butyl isothiocyanate

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

3,8-di-n-butyl-2,7-di-n-butylthio-4,9-diimino-3,4,8,9-tetrahydropyrimido[4,5-g]pteridine
152093-03-3

3,8-di-n-butyl-2,7-di-n-butylthio-4,9-diimino-3,4,8,9-tetrahydropyrimido[4,5-g]pteridine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 0.166667h;72%
cyclohexanone
108-94-1

cyclohexanone

methylamine
74-89-5

methylamine

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

4,9-bis(methylamino)bisspiro[1,2,6,7-tetrahydropyrimido[4,5-g]pteridine[2,1':7,1'']biscyclohexane]

4,9-bis(methylamino)bisspiro[1,2,6,7-tetrahydropyrimido[4,5-g]pteridine[2,1':7,1'']biscyclohexane]

Conditions
ConditionsYield
Stage #1: methylamine; 3,6-diaminopyrazine-2,5-dicarbonitrile In ethanol; N,N-dimethyl-formamide at 20℃; for 144h;
Stage #2: cyclohexanone In ethanol; N,N-dimethyl-formamide for 0.5h; Heating;		43%
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

Tert-butyl isocyanate
1609-86-5

Tert-butyl isocyanate

A

5-amino-3-tert-butyl-6-cyano-1H-2,3-dihydroimidazo[4,5-b]pyrazin-2-one

5-amino-3-tert-butyl-6-cyano-1H-2,3-dihydroimidazo[4,5-b]pyrazin-2-one

B

3-tert-butyl-5-(1-N-tert-butylcarbamoylamino)-6-cyano-1H-2,3-dihydroimidazo[4,5-b]pyrazin-2-one

3-tert-butyl-5-(1-N-tert-butylcarbamoylamino)-6-cyano-1H-2,3-dihydroimidazo[4,5-b]pyrazin-2-one

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h;A 20%
B 36%
n-butyl isocyanide
111-36-4

n-butyl isocyanide

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

3,7-dibutyl-8-imino-2,6-dioxo-1,2,3,6,7,8-hexahydro-1,3,4,5,7,9-hexaaza-cyclopenta[b]naphthalene-5-carboxylic acid butylamide

3,7-dibutyl-8-imino-2,6-dioxo-1,2,3,6,7,8-hexahydro-1,3,4,5,7,9-hexaaza-cyclopenta[b]naphthalene-5-carboxylic acid butylamide

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h;23%
propylamine
107-10-8

propylamine

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

A

3,6-diamino-5-cyano-N-propyl-pyrazine-2-carboxamidine

3,6-diamino-5-cyano-N-propyl-pyrazine-2-carboxamidine

B

C12H22N8

C12H22N8

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 20℃; for 9h;A 14%
B 15%
4-Fluorobenzyl bromide
459-46-1

4-Fluorobenzyl bromide

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C34H24F4N6

C34H24F4N6

Conditions
ConditionsYield
Stage #1: 4-Fluorobenzyl bromide; 3,6-diaminopyrazine-2,5-dicarbonitrile With N,N-dimethyl acetamide at 0℃; for 0.5h;
Stage #2: With sodium hydroxide at 20℃; for 0.5h;		5%
1-Iodoheptane
4282-40-0

1-Iodoheptane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-diheptylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-diheptylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;4.4%
1-Iodododecane
4292-19-7

1-Iodododecane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-didodecylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-didodecylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;4.2%
1-bromomethyl-4-iodobenzene
16004-15-2

1-bromomethyl-4-iodobenzene

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C34H24I4N6

C34H24I4N6

Conditions
ConditionsYield
Stage #1: 1-bromomethyl-4-iodobenzene; 3,6-diaminopyrazine-2,5-dicarbonitrile With N,N-dimethyl acetamide at 0℃; for 0.5h;
Stage #2: With sodium hydroxide at 20℃; for 0.5h;		4%
1-Iodohexane
638-45-9

1-Iodohexane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-dihexylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-dihexylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;3.4%
1-Iodooctane
629-27-6

1-Iodooctane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-dioctylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-dioctylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;3.3%
n-iodooctadecane
629-93-6

n-iodooctadecane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-dioctadecylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-dioctadecylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;1.7%
1-iodohexadecane
544-77-4

1-iodohexadecane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,5-bis(N,N-dihexadecylamino)-3,6-dicyanopyrazine

2,5-bis(N,N-dihexadecylamino)-3,6-dicyanopyrazine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;1.5%
2,4,6-trimethylbenzylbromide
4761-00-6

2,4,6-trimethylbenzylbromide

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

3,6-bis-[bis-(2,4,6-trimethyl-benzyl)-amino]-pyrazine-2,5-dicarbonitrile

3,6-bis-[bis-(2,4,6-trimethyl-benzyl)-amino]-pyrazine-2,5-dicarbonitrile

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

3,8-di-n-butyl-1,2,3,4,6,7,8,9-octahydropyrimido[4,5-g]pteridine-2,4,7,9-tetrone
152093-27-1

3,8-di-n-butyl-1,2,3,4,6,7,8,9-octahydropyrimido[4,5-g]pteridine-2,4,7,9-tetrone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / NaH / dimethylformamide / 0.17 h
2: 87 percent / 6N aq. H2SO4 / propan-1-ol / 24 h / Heating
View Scheme
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

2,7-diphenyl-4,9-bis(n-propylamino)pyrimido[4,5-g]pteridine

2,7-diphenyl-4,9-bis(n-propylamino)pyrimido[4,5-g]pteridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 15 percent / N,N-dimethyl-acetamide / 9 h / 20 °C
2: dimethylformamide / 1 h / Heating
View Scheme
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

1,3,5,7-tetra-n-butyl-1H-2,3,5,6,7,8-hexahydroimidazo[4,5-g]pteridine-2,6,8-trione

1,3,5,7-tetra-n-butyl-1H-2,3,5,6,7,8-hexahydroimidazo[4,5-g]pteridine-2,6,8-trione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / NaH / dimethylformamide / 0.17 h
2: 87 percent / 6N aq. H2SO4 / propan-1-ol / 24 h / Heating
3: 11 percent / K2CO3 / dimethylformamide / 2 h / Heating
View Scheme
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

1,3,6,8-tetra-n-butyl-1,2,3,4,6,7,8,9-octahydropyrimido[4,5-g]pteridine-2,4,7,9-tetrone

1,3,6,8-tetra-n-butyl-1,2,3,4,6,7,8,9-octahydropyrimido[4,5-g]pteridine-2,4,7,9-tetrone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / NaH / dimethylformamide / 0.17 h
2: 87 percent / 6N aq. H2SO4 / propan-1-ol / 24 h / Heating
3: 74 percent / K2CO3 / dimethylformamide / 2 h / Heating
View Scheme
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C30H44N6O8

C30H44N6O8

Conditions
ConditionsYield
With sodium hydroxide In ISOPROPYLAMIDE at 0 - 20℃; for 1 - 2h;
Iodoethanol
624-76-0

Iodoethanol

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C14H24N6O6

C14H24N6O6

Conditions
ConditionsYield
Stage #1: Iodoethanol; 3,6-diaminopyrazine-2,5-dicarbonitrile With sodium hydroxide In ISOPROPYLAMIDE at 0 - 20℃; for 2h;
Stage #2: With sulfuric acid at 20℃; for 3h;
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C18H38N8O6Si2
1358918-80-5

C18H38N8O6Si2

Conditions
ConditionsYield
at 70℃; for 24h;
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C48H36N6

C48H36N6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(ll) bromide; tert.-butylnitrite / water; acetonitrile / 2 h / 40 °C
2: tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium(0) / toluene
View Scheme
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

3,6-dibromopyrazine-2,5-dicarbonitrile
1391026-27-9

3,6-dibromopyrazine-2,5-dicarbonitrile

Conditions
ConditionsYield
With tert.-butylnitrite; copper(ll) bromide In water; acetonitrile at 40℃; for 2h; Temperature; Solvent; Reagent/catalyst;45.34 g
1-iodo-butane
542-69-8

1-iodo-butane

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C22H36N6

C22H36N6

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;
amyl iodide
628-17-1

amyl iodide

3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

C26H44N6

C26H44N6

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 20℃;
3,6-diaminopyrazine-2,5-dicarbonitrile
133940-72-4

3,6-diaminopyrazine-2,5-dicarbonitrile

ethylhalide

ethylhalide

C14H20N6

C14H20N6

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide

133940-72-4Upstream product

133940-72-4Relevant articles and documents

DICYANOPYRAZINE COMPOUND, LUMINESCENT MATERIAL, LUMINESCENCE DEVICE USING THE SAME, AND METHOD FOR PRODUCING 2,5-DICYANO-3,6-DIHALOGENOPYRAZINE

-

Paragraph 0276; 0277, (2018/10/19)

A compound represented by formula (I) or formula (1I): in formula (I), R3 represents an electron donating group, R4 represents a hydrogen atom, a substituted or unsubstituted aryl group or an electron donating group, L3 represents a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L4 represents a single bond, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L3 and L4 may bond together to form a ring with the carbon atoms to which they are bonded, in formula (II), R5 represents an electron donating group, R6 represents a hydrogen atom, a substituted or unsubstituted aryl group or an electron donating group, L5 represents a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L6 represents a single bond, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group.

3,6-diamino-2,5-pyrazinedicarbonitrile

-

, (2008/06/13)

This invention relates to 3,6-diamino-2,5-pyrazinedicarbonitrile which is a red crystal and yellowish green fluorescent substance and the methods of preparation from compounds represented by formula [I], STR1 (wherein R are aryl, alkyl, aralkyl or alkenyl

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 133940-72-4