1185166-01-1 Usage
Description
METFORMIN-D6, HYDROCHLORIDE is a white crystalline solid that serves as an internal standard for the quantification of metformin by GCor LC-MS. Metformin is a biguanide with diverse biological activities, including its use as an oral hypoglycemic agent for the treatment of type 2 diabetes.
Uses
Used in Pharmaceutical Industry:
METFORMIN-D6, HYDROCHLORIDE is used as an internal standard for the quantification of metformin in the pharmaceutical industry. This aids in the accurate measurement and dosing of metformin, which is crucial for its effectiveness as an oral hypoglycemic agent.
Used in Diabetes Treatment:
METFORMIN-D6, HYDROCHLORIDE is used as an oral hypoglycemic agent for the treatment of type 2 diabetes. It helps in reducing blood glucose levels by more than 50% in mice fed normal and high-fat diets, and by 40% in ob/ob mice. This makes it a valuable tool in managing blood sugar levels and improving the overall health of diabetic patients.
Used in Weight Management:
METFORMIN-D6, HYDROCHLORIDE is used to reduce weight gain and hepatic lipid droplet content in diet-induced obese mice. Administered at doses of 10 or 50 mg/kg per day, it also lowers total cholesterol, LDL cholesterol, and triglyceride levels in the plasma, contributing to better weight management and overall health.
Used in Non-alcoholic Fatty Liver Disease (NAFLD) Treatment:
METFORMIN-D6, HYDROCHLORIDE is used to reverse increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of NAFLD. This application highlights its potential in treating liver-related conditions associated with obesity and diabetes.
Used in Cancer Treatment:
METFORMIN-D6, HYDROCHLORIDE is used to reduce tumor growth in an HCT116 p53-human colon cancer mouse xenograft model. Although it has no effect on HCT116 p53-tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, its potential role in cancer treatment is noteworthy and warrants further research.
Check Digit Verification of cas no
The CAS Registry Mumber 1185166-01-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,1,6 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1185166-01:
(9*1)+(8*1)+(7*8)+(6*5)+(5*1)+(4*6)+(3*6)+(2*0)+(1*1)=151
151 % 10 = 1
So 1185166-01-1 is a valid CAS Registry Number.
